Zhihu Li1, Wei Huang1, Xiaoyan Wang1, Yong Zhang2. 1. Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 2. Neurology Research Division, China National Clinical Research Center for Neurological Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China - 289625835@qq.com.
Abstract
INTRODUCTION: While several epidemiologic studies have investigated the relationship between lower urinary tract symptoms (LUTS) and irritable bowel syndrome (IBS), it remains unclear. To investigate the relationship between IBS and LUTS, a systematic review and meta-analysis of cross-sectional studies was carried out. EVIDENCE ACQUISITION: Online databases were searched up to December 1st, 2017 for cross-sectional studies that evaluated the association between IBS and the risk of LUTS. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. EVIDENCE SYNTHESIS: In all, 9 articles that contained 19907 participants and 2620 cases of LUTS were included in this meta-analysis. Compared with the non-IBS group, the IBS group had a higher risk of LUTS (total OR=2.11, 95% CI: 1.91-2.33, P<0.00001). Patients with IBS were more likely to have urine storage symptoms (total OR=1.80, 95% CI: 1.34-2.42, P<0.0001). Subgroup analysis by gender showed that the IBS group had a higher risk of LUTS in both men (total OR=2.17, 95% CI: 1.82-2.58, P<0.00001) and women (total OR=1.85, 95% CI: 1.57-2.17, P<0.00001). CONCLUSIONS: Our meta-analysis provides evidence that IBS is associated with an increased risk of LUTS in both men and women.
INTRODUCTION: While several epidemiologic studies have investigated the relationship between lower urinary tract symptoms (LUTS) and irritable bowel syndrome (IBS), it remains unclear. To investigate the relationship between IBS and LUTS, a systematic review and meta-analysis of cross-sectional studies was carried out. EVIDENCE ACQUISITION: Online databases were searched up to December 1st, 2017 for cross-sectional studies that evaluated the association between IBS and the risk of LUTS. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. EVIDENCE SYNTHESIS: In all, 9 articles that contained 19907 participants and 2620 cases of LUTS were included in this meta-analysis. Compared with the non-IBS group, the IBS group had a higher risk of LUTS (total OR=2.11, 95% CI: 1.91-2.33, P<0.00001). Patients with IBS were more likely to have urine storage symptoms (total OR=1.80, 95% CI: 1.34-2.42, P<0.0001). Subgroup analysis by gender showed that the IBS group had a higher risk of LUTS in both men (total OR=2.17, 95% CI: 1.82-2.58, P<0.00001) and women (total OR=1.85, 95% CI: 1.57-2.17, P<0.00001). CONCLUSIONS: Our meta-analysis provides evidence that IBS is associated with an increased risk of LUTS in both men and women.