Literature DB >> 29594407

[Fatal flecainide intoxication in a 17-year-old girl].

M Dokter1, G Talarico2, S Armbrust3, E Below2, B Bockholdt2.   

Abstract

A 17-year-old girl was found vomiting and somnolent at home and was taken to a hospital. The girl initially presented with ventricular tachycardia with broad QRS complexes which was very difficult to control. During the course a subsequent cardiogenic shock developed and despite exhaustion of all therapeutic options the fatal outcome could not be averted. The medicolegal autopsy revealed no evidence of any form of violence but the signs of medical treatment. Furthermore, no pathology of internal organs was detected. The toxicological analyses revealed a lethal intoxication with flecainide as the cause of death. The investigations of the police indicated that the girl took flecainide in suicidal intention.

Entities:  

Keywords:  Antiarrhythmic; Class-Ic; Intoxication; Suicide; Ventricular tachycardia

Mesh:

Substances:

Year:  2018        PMID: 29594407     DOI: 10.1007/s00101-018-0434-5

Source DB:  PubMed          Journal:  Anaesthesist        ISSN: 0003-2417            Impact factor:   1.041


  7 in total

Review 1.  Supraventricular tachycardia in infants, children and adolescents: diagnosis, and pharmacological and interventional therapy.

Authors:  T Paul; H Bertram; R Bökenkamp; G Hausdorf
Journal:  Paediatr Drugs       Date:  2000 May-Jun       Impact factor: 3.022

2.  Clinical course and outcome in class IC antiarrhythmic overdose.

Authors:  C Köppel; U Oberdisse; G Heinemeyer
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Authors:  R Aderjan; R Mattern
Journal:  Z Rechtsmed       Date:  1980

4.  Fatal flecainide intoxication.

Authors:  N Romain; C Giroud; K Michaud; M Augsburger; P Mangin
Journal:  Forensic Sci Int       Date:  1999-12-06       Impact factor: 2.395

5.  Fatal flecainide intoxication.

Authors:  E Brazil; G G Bodiwala; D C Bouch
Journal:  J Accid Emerg Med       Date:  1998-11

6.  Primary and secondary detoxification in severe flecainide intoxication.

Authors:  D Götz; S Pohle; D Barckow
Journal:  Intensive Care Med       Date:  1991       Impact factor: 17.440

7.  Life-threatening flecainide intoxication in a young child secondary to medication error.

Authors:  Lisa C A D'Alessandro; Michael J Rieder; Jane Gloor; David Freeman; Ilan Buffo-Sequiera
Journal:  Ann Pharmacother       Date:  2009-08-11       Impact factor: 3.154

  7 in total

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