Literature DB >> 29588717

The FAME Trials: Impact on Clinical Decision Making.

Guy R Heyndrickx1, Gábor G Tóth2.   

Abstract

Careful and stepwise evaluation of the fractional flow reserve (FFR) index has been performed over the years, culminating in the landmark Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (FAME) and Fractional Flow Reserve-Guided Percutaneous Coronary Intervention Plus Optimal Medical Treatment Versus Optimal Medical Treatment Alone in Patients with Stable Coronary Artery Disease (FAME II) trials. Findings from these studies demonstrated unequivocally the overall inadequacy of angiography versus FFR to correctly assess stenosis severity. Thus, proof of concept and clinical applicability was established beyond debate and will be discussed here.

Entities:  

Keywords:  Coronary artery disease; FAME; angiography; fractional flow reserve; ischaemia

Year:  2016        PMID: 29588717      PMCID: PMC5808511          DOI: 10.15420/icr.2016:14:3

Source DB:  PubMed          Journal:  Interv Cardiol        ISSN: 1756-1485


  25 in total

Review 1.  Contributions of nuclear cardiology to diagnosis and prognosis of patients with coronary artery disease.

Authors:  G A Beller; B L Zaret
Journal:  Circulation       Date:  2000-03-28       Impact factor: 29.690

2.  Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation) study.

Authors:  Nico H J Pijls; William F Fearon; Pim A L Tonino; Uwe Siebert; Fumiaki Ikeno; Bernhard Bornschein; Marcel van't Veer; Volker Klauss; Ganesh Manoharan; Thomas Engstrøm; Keith G Oldroyd; Peter N Ver Lee; Philip A MacCarthy; Bernard De Bruyne
Journal:  J Am Coll Cardiol       Date:  2010-05-28       Impact factor: 24.094

3.  Impact of right atrial pressure on decision-making using fractional flow reserve (FFR) in elective percutaneous intervention.

Authors:  Jamie Layland; Andrew M Wilson; Robert J Whitbourn; Andrew T Burns; Jithendra Somaratne; George Leitl; Andrew I Macisaac
Journal:  Int J Cardiol       Date:  2012-04-02       Impact factor: 4.164

4.  Clinical utility of regadenoson for assessing fractional flow reserve.

Authors:  Pradeep K Nair; Oscar C Marroquin; Suresh R Mulukutla; Sameer Khandhar; Vijay Gulati; John T Schindler; Joon S Lee
Journal:  JACC Cardiovasc Interv       Date:  2011-10       Impact factor: 11.195

5.  Letter to the editor: The influence of right atrial pressure on fractional flow reserve.

Authors:  Gautam Kumar
Journal:  J Invasive Cardiol       Date:  2012-10       Impact factor: 2.022

6.  Fractional flow reserve calculation from 3-dimensional quantitative coronary angiography and TIMI frame count: a fast computer model to quantify the functional significance of moderately obstructed coronary arteries.

Authors:  Shengxian Tu; Emanuele Barbato; Zsolt Köszegi; Junqing Yang; Zhonghua Sun; Niels R Holm; Balázs Tar; Yingguang Li; Dan Rusinaru; William Wijns; Johan H C Reiber
Journal:  JACC Cardiovasc Interv       Date:  2014-07       Impact factor: 11.195

7.  Impact of Right Atrial Pressure on Fractional Flow Reserve Measurements: Comparison of Fractional Flow Reserve and Myocardial Fractional Flow Reserve in 1,600 Coronary Stenoses.

Authors:  Gabor G Toth; Bernard De Bruyne; Dan Rusinaru; Giuseppe Di Gioia; Jozef Bartunek; Mariano Pellicano; Marc Vanderheyden; Julien Adjedj; William Wijns; Nico H J Pijls; Emanuele Barbato
Journal:  JACC Cardiovasc Interv       Date:  2016-02-17       Impact factor: 11.195

Review 8.  alpha-adrenergic coronary vasoconstriction and myocardial ischemia in humans.

Authors:  G Heusch; D Baumgart; P Camici; W Chilian; L Gregorini; O Hess; C Indolfi; O Rimoldi
Journal:  Circulation       Date:  2000-02-15       Impact factor: 29.690

9.  Significance of Intermediate Values of Fractional Flow Reserve in Patients With Coronary Artery Disease.

Authors:  Julien Adjedj; Bernard De Bruyne; Vincent Floré; Giuseppe Di Gioia; Angela Ferrara; Mariano Pellicano; Gabor G Toth; Jozef Bartunek; Marc Vanderheyden; Guy R Heyndrickx; William Wijns; Emanuele Barbato
Journal:  Circulation       Date:  2016-01-05       Impact factor: 29.690

10.  Fractional flow reserve vs. angiography in guiding management to optimize outcomes in non-ST-segment elevation myocardial infarction: the British Heart Foundation FAMOUS-NSTEMI randomized trial.

Authors:  Jamie Layland; Keith G Oldroyd; Nick Curzen; Arvind Sood; Kanarath Balachandran; Raj Das; Shahid Junejo; Nadeem Ahmed; Matthew M Y Lee; Aadil Shaukat; Anna O'Donnell; Julian Nam; Andrew Briggs; Robert Henderson; Alex McConnachie; Colin Berry
Journal:  Eur Heart J       Date:  2014-09-01       Impact factor: 29.983

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