| Literature DB >> 29582189 |
Marc El Beaino1, Jason Roszik2, John A Livingston3, Wei-Lien Wang4, Alexander J Lazar4, Behrang Amini5, Vivek Subbiah6, Valerae Lewis1, Anthony P Conley7.
Abstract
Mesenchymal chondrosarcoma is a rare but deadly form of chondrosarcoma that typically affects adolescents and young adults. While curative intent is possible for patients with localized disease, few options exist for patients in the unresectable/metastatic setting. Thus, it is imperative to understand the fusion-driven biology of this rare malignant neoplasm so as to lead to the future development of better therapeutics for this disease. This manuscript will briefly review the clinical and pathologic features of mesenchymal chondrosarcoma followed by an appraisal of existing data linked to the fusions, HEY1-NCOA2 and IRF2BP2-CDX1, and the associated downstream pathways.Entities:
Keywords: Apoptosis; CDX1; Chondrosarcoma; Chromatin remodeling; Fusion; Genomics; HEY1; IRF2BP2; Mesenchymal chondrosarcoma; NCOA2; Notch; Pathways; TGF beta; Translocation
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Year: 2018 PMID： 29582189 DOI： 10.1007/s11912-018-0668-z
Source DB: PubMed Journal: Curr Oncol Rep ISSN： 1523-3790 Impact factor: 5.075