Christine L Chan1, Timothy Vigers2, Laura Pyle3, Philip S Zeitler2, Scott D Sagel4, Kristen J Nadeau2. 1. Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States. Electronic address: Christinel.chan@childrenscolorado.org. 2. Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States. 3. Department of Pediatrics, Division of Pediatric Endocrinology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States. 4. Department of Pediatrics, Division of Pediatric Pulmonology, Children's Hospital Colorado and University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Abstract
BACKGROUND: To characterize glucose patterns with continuous glucose monitoring (CGM) in cystic fibrosis (CF) and assess relationships between CGM and clinical outcomes. METHODS: 110 CF youth and healthy controls (HC), 10-18 years, wore CGM up to 7 days. Correlations between CGM and lung function and BMI z-score change over the prior year were determined. RESULTS: Multiple CGM measures were higher in CF Normal Glycemic (CFNG) youth versus HC (peak glucose, excursions >140 mg/dl/day, %time > 140 mg/dl, standard deviation (SD) and mean amplitude of glycemic excursions (MAGE)). Hypoglycemia was no different among groups. In CF, decline in FEV1% and FVC% correlated with maximum CGM glucose, excursions >200 mg/dl/day, SD, and MAGE. CONCLUSIONS: CFNG youth have higher glucoses and glucose variability than HC on CGM. Higher and more variable glucoses correlate with lung function decline. Whether earlier treatment of CGM abnormalities improves lung function in CF requires further study.
BACKGROUND: To characterize glucose patterns with continuous glucose monitoring (CGM) in cystic fibrosis (CF) and assess relationships between CGM and clinical outcomes. METHODS: 110 CF youth and healthy controls (HC), 10-18 years, wore CGM up to 7 days. Correlations between CGM and lung function and BMI z-score change over the prior year were determined. RESULTS: Multiple CGM measures were higher in CF Normal Glycemic (CFNG) youth versus HC (peak glucose, excursions >140 mg/dl/day, %time > 140 mg/dl, standard deviation (SD) and mean amplitude of glycemic excursions (MAGE)). Hypoglycemia was no different among groups. In CF, decline in FEV1% and FVC% correlated with maximum CGMglucose, excursions >200 mg/dl/day, SD, and MAGE. CONCLUSIONS: CFNG youth have higher glucoses and glucose variability than HC on CGM. Higher and more variable glucoses correlate with lung function decline. Whether earlier treatment of CGM abnormalities improves lung function in CF requires further study.
Authors: Jill Brodsky; Shayne Dougherty; Ramkrishna Makani; Ronald C Rubenstein; Andrea Kelly Journal: Diabetes Care Date: 2011-01-12 Impact factor: 19.112
Authors: Christine L Chan; Emma Hope; Jessica Thurston; Timothy Vigers; Laura Pyle; Philip S Zeitler; Kristen J Nadeau Journal: Diabetes Care Date: 2018-04-19 Impact factor: 19.112
Authors: Kevin J Scully; Jordan S Sherwood; Kimberly Martin; Melanie Ruazol; Peter Marchetti; Mary Larkin; Hui Zheng; Gregory S Sawicki; Ahmet Uluer; Isabel Neuringer; Lael M Yonker; Leonard Sicilian; Deborah J Wexler; Melissa S Putman Journal: J Clin Endocrinol Metab Date: 2022-03-24 Impact factor: 5.958
Authors: Christine L Chan; Laura Pyle; Tim Vigers; Philip S Zeitler; Kristen J Nadeau Journal: J Clin Endocrinol Metab Date: 2022-01-18 Impact factor: 6.134
Authors: Angel Li; Tim Vigers; Laura Pyle; Edith Zemanick; Kristen Nadeau; Scott D Sagel; Christine L Chan Journal: J Cyst Fibros Date: 2018-08-10 Impact factor: 5.482
Authors: Kalie L Tommerdahl; John T Brinton; Tim Vigers; Melanie Cree-Green; Philip S Zeitler; Kristen J Nadeau; Christine L Chan Journal: J Cyst Fibros Date: 2020-09-11 Impact factor: 5.482
Authors: Charles D Bengtson; Michael D Kim; Abeer Anabtawi; Jianghua He; John S Dennis; Sara Miller; Makoto Yoshida; Nathalie Baumlin; Matthias Salathe Journal: Eur Respir J Date: 2021-01-14 Impact factor: 16.671