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Literature DB >> 29577985

RND transporters in the living world.

Abstract

Transporters of the RND superfamily are well-known as the major drug efflux pumps of Gram-negative bacteria. However, they are widespread in organisms ranging from Archaea to Eukaryotes, and perform diverse functions. This review gives a brief overview of these diverse members of the superfamily with emphasis on their structure and functions.

Entities: Chemical Disease Gene Species

Keywords: Phylogeny; Quaternary structure; Superfamily

Mesh：

Substances：

Year: 2018 PMID： 29577985 PMCID： PMC6151166 DOI： 10.1016/j.resmic.2018.03.001

Source DB: PubMed Journal: Res Microbiol ISSN： 0923-2508 Impact factor: 3.992

61 in total

1. LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis.

Authors: Gerlind Sulzenbacher; Stéphane Canaan; Yann Bordat; Olivier Neyrolles; Gustavo Stadthagen; Véronique Roig-Zamboni; Jean Rauzier; Damien Maurin; Françoise Laval; Mamadou Daffé; Christian Cambillau; Brigitte Gicquel; Yves Bourne; Mary Jackson
Journal: EMBO J Date: 2006-03-16 Impact factor: 11.598

2. Switch or funnel: how RND-type transport systems control periplasmic metal homeostasis.

Authors: Eun-Hae Kim; Dietrich H Nies; Megan M McEvoy; Christopher Rensing
Journal: J Bacteriol Date: 2011-03-11 Impact factor: 3.490

3. Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli.

Authors: Hong-Suk Kim; Hiroshi Nikaido
Journal: Biochemistry Date: 2012-05-11 Impact factor: 3.162

4. Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.

Authors: Wei Li; Ashutosh Upadhyay; Fabio L Fontes; E Jeffrey North; Yuehong Wang; Debbie C Crans; Anna E Grzegorzewicz; Victoria Jones; Scott G Franzblau; Richard E Lee; Dean C Crick; Mary Jackson
Journal: Antimicrob Agents Chemother Date: 2014-08-18 Impact factor: 5.191

5. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning.

Authors: J E Hooper; M P Scott
Journal: Cell Date: 1989-11-17 Impact factor: 41.582

Review 6. Multidrug permeases and subcellular cholesterol transport.

Authors: Y A Ioannou
Journal: Nat Rev Mol Cell Biol Date: 2001-09 Impact factor: 94.444

7. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.

Authors: Kapil Tahlan; Regina Wilson; David B Kastrinsky; Kriti Arora; Vinod Nair; Elizabeth Fischer; S Whitney Barnes; John R Walker; David Alland; Clifton E Barry; Helena I Boshoff
Journal: Antimicrob Agents Chemother Date: 2012-01-17 Impact factor: 5.191

Review 8. Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking.

Authors: Judith Storch; Zhi Xu
Journal: Biochim Biophys Acta Date: 2009-02-13

9. MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence.

Authors: Scott E Converse; Joseph D Mougous; Michael D Leavell; Julie A Leary; Carolyn R Bertozzi; Jeffery S Cox
Journal: Proc Natl Acad Sci U S A Date: 2003-04-30 Impact factor: 11.205

10. Patched acts catalytically to suppress the activity of Smoothened.

Authors: J Taipale; M K Cooper; T Maiti; P A Beachy
Journal: Nature Date: 2002-08-22 Impact factor: 49.962

28 in total

1. Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations.

Authors: Kostadin Petrov; Taciani de Almeida Magalhaes; Adrian Salic
Journal: Proc Natl Acad Sci U S A Date: 2021-02-09 Impact factor: 11.205

2. Antibiotic Substrate Selectivity of Pseudomonas aeruginosa MexY and MexB Efflux Systems Is Determined by a Goldilocks Affinity.

Authors: Debayan Dey; Logan G Kavanaugh; Graeme L Conn
Journal: Antimicrob Agents Chemother Date: 2020-07-22 Impact factor: 5.191

RND transporters in the living world.

1. LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis.

2. Switch or funnel: how RND-type transport systems control periplasmic metal homeostasis.

3. Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coli.

4. Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis.

5. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning.

Review 6. Multidrug permeases and subcellular cholesterol transport.

7. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.

Review 8. Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking.

9. MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence.

10. Patched acts catalytically to suppress the activity of Smoothened.

1. Mechanism and ultrasensitivity in Hedgehog signaling revealed by Patched1 disease mutations.

2. Antibiotic Substrate Selectivity of Pseudomonas aeruginosa MexY and MexB Efflux Systems Is Determined by a Goldilocks Affinity.

3. Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.

4. Efflux identification and engineering for ansamitocin P-3 production in Actinosynnema pretiosum.

5. Computational design of MmpL3 inhibitors for tuberculosis therapy.

6. Distinct Cation Gradients Power Cholesterol Transport at Different Key Points in the Hedgehog Signaling Pathway.

Review 7. The evolution of MarR family transcription factors as counter-silencers in regulatory networks.

Review 8. Structural and Functional Diversity of Resistance-Nodulation-Cell Division Transporters.

9. The Whole Is Bigger than the Sum of Its Parts: Drug Transport in the Context of Two Membranes with Active Efflux.

10. Chimeric vaccine designs against Acinetobacter baumannii using pan genome and reverse vaccinology approaches.