Literature DB >> 11533723

Multidrug permeases and subcellular cholesterol transport.

Y A Ioannou1.   

Abstract

Studies of Niemann-Pick C (NPC) and Tangier diseases have led to the identification of the causative genes, NPC1 and ABCA1, respectively. Characterization of their protein products shows that NPC1 and ABCA1 are permeases that belong to two different superfamilies of efflux pumps, which might be important in subcellular lipid and cholesterol transport.

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Year:  2001        PMID： 11533723     DOI： 10.1038/35089558

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  20 in total

1.  Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance.

Authors:  David Jelinek; Veronica Millward; Amandip Birdi; Theodore P Trouard; Randall A Heidenreich; William S Garver
Journal:  Hum Mol Genet       Date:  2010-10-29       Impact factor: 6.150

Review 2.  RND transporters in the living world.

Authors:  Hiroshi Nikaido
Journal:  Res Microbiol       Date:  2018-03-22       Impact factor: 3.992

3.  The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

Authors:  Margarita Garcia-Calvo; JeanMarie Lisnock; Herbert G Bull; Brian E Hawes; Duane A Burnett; Matthew P Braun; James H Crona; Harry R Davis; Dennis C Dean; Patricia A Detmers; Michael P Graziano; Meredith Hughes; D Euan Macintyre; Anthony Ogawa; Kim A O'neill; Sai Prasad N Iyer; Diane E Shevell; Marsha M Smith; Yui S Tang; Amanda M Makarewicz; Feroze Ujjainwalla; Scott W Altmann; Kevin T Chapman; Nancy A Thornberry
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-31       Impact factor: 11.205

4.  Maintenance of Membrane Integrity and Permeability Depends on a Patched-Related Protein in Caenorhabditis elegans.

Authors:  Myung-Kyu Choi; Sangwon Son; Mingi Hong; Min Sung Choi; Jae Young Kwon; Junho Lee
Journal:  Genetics       Date:  2016-02-08       Impact factor: 4.562

5.  Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis.

Authors:  Chris D Pacheco; Matthew J Elrick; Andrew P Lieberman
Journal:  Hum Mol Genet       Date:  2008-12-12       Impact factor: 6.150

6.  Genetic evidence for nonredundant functional cooperativity between NPC1 and NPC2 in lipid transport.

Authors:  David E Sleat; Jennifer A Wiseman; Mukarram El-Banna; Sandy M Price; Lucie Verot; Michael M Shen; G Stephen Tint; Marie T Vanier; Steven U Walkley; Peter Lobel
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-07       Impact factor: 11.205

Review 7.  Gemfibrozil, stretching arms beyond lipid lowering.

Authors:  Avik Roy; Kalipada Pahan
Journal:  Immunopharmacol Immunotoxicol       Date:  2009       Impact factor: 2.730

8.  Cholesterol is required for endocytosis and endosomal escape of adenovirus type 2.

Authors:  Nicola Imelli; Oliver Meier; Karin Boucke; Silvio Hemmi; Urs F Greber
Journal:  J Virol       Date:  2004-03       Impact factor: 5.103

Review 9.  Sphingolipid lysosomal storage disorders.

Authors:  Frances M Platt
Journal:  Nature       Date:  2014-06-05       Impact factor: 49.962

10.  Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction.

Authors:  Alan Jian Zhu; Limin Zheng; Kaye Suyama; Matthew P Scott
Journal:  Genes Dev       Date:  2003-05-02       Impact factor: 11.361
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