Literature DB >> 29577202

Compounds of IL-6 Receptor Complex during Acute Lung Injury.

D A Chepurnova1, E V Samoilova2, A A Anisimov2, A D Verin3, A A Korotaeva2.   

Abstract

Soluble receptor of IL-6 (sIL-6R) and antagonist of the receptor complex, soluble glycoprotein 130 (sgp130) mediate opposite effects during inflammation. We measured the levels of these cytokines and their ratio in rat blood on the model of acute lung injury. The injury was modeled by the intratracheal administration of LPS. The levels of sgp130 and sIL-6R increased during the inflammatory process in the injured lungs. The sgp130/sIL-6R ratio increased or decreased depending on the intensity of the inflammatory process. sgp130/sIL-6R ratio might reflect the intensity of inflammation during lung injury.

Entities:  

Keywords:  acute lung injury; inflammation; sgp130; soluble receptor of IL-6

Mesh：

Substances：

Year:  2018        PMID： 29577202      PMCID： PMC6428418          DOI： 10.1007/s10517-018-4042-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  8 in total

1.  Extracellular Matrix Components of Rat Lungs after Direct and Indirect Lung Injury.

Authors:  Е V Samoilova; D A Chepurnova; A G Fesenko; А А Korotaeva
Journal:  Bull Exp Biol Med       Date:  2022-02-17       Impact factor: 0.804

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Journal:  J Mol Med (Berl)       Date:  2022-03-06       Impact factor: 4.599

3.  Effects and early diagnostic value of lncRNA H19 on sepsis-induced acute lung injury.

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Journal:  Exp Ther Med       Date:  2022-02-14       Impact factor: 2.447

4.  Prediction of immune factors and signaling pathways in lung injury induced by LPS based on network analysis.

Authors:  Kaiwei Wang; Haoran Zhang; Jiaqiang Zhang; Erju Jia; Guosong Zhu
Journal:  Saudi J Biol Sci       Date:  2019-09-13       Impact factor: 4.219

5.  Hydrostatin-SN10 Ameliorates Pancreatitis-Induced Lung Injury by Affecting IL-6-Induced JAK2/STAT3-Associated Inflammation and Oxidative Stress.

Authors:  Xuehua Piao; Yanping Zou; Xiaodan Sui; Baohai Liu; Fanji Meng; Shuangdi Li; Qingyu Zhang; Chi Ma; Tong Wu
Journal:  Oxid Med Cell Longev       Date:  2019-11-18       Impact factor: 6.543

6.  Total alveolar lavage with oxygen fine bubble dispersion directly improves lipopolysaccharide-induced acute respiratory distress syndrome of rats.

Authors:  Kenta Kakiuchi; Takehiro Miyasaka; Shinji Takeoka; Kenichi Matsuda; Norikazu Harii
Journal:  Sci Rep       Date:  2020-10-06       Impact factor: 4.379

7.  Interleukin IL-5 alleviates sepsis-induced acute lung injury by regulating the immune response in rats.

Authors:  Beichun Wei; Yu Chen; Wangmei Zhou; Xu Li; Lei Shi; Shengwu Liao
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

8.  MicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway.

Authors:  Anna Nong; Qingfeng Li; Zhijing Huang; Yunan Xu; Kebin He; Yuying Jia; Zhenyi Cen; Lianghua Liao; Yueyan Huang
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269
  8 in total

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