Immune responses to engineered nanomaterials: current understanding and challenges.

Engineered nanomaterials (ENM) are utilized in many applications due to their unique physicochemical properties. The increasing use of ENMs in consumer products raises concerns of potential adverse effects in humans and the environment. A common outcome of exposure (intentional, environmental or occupational) to ENMs is altered immune responses including inflammation, hypersensitivity, and immunosuppression. ENMs have been shown to interact with the immune system through key effector cells (i.e. mast cells and antigen presenting cells) or via complement activation leading to consequences to both innate and adaptive immunity. Further, upon introduction into a biological system, ENMs are rapidly coated with proteins, lipids and other macromolecules forming a biocorona which impacts immune cell and complement responses. In this current opinion, we highlight key studies and challenges in understanding cellular mechanisms of ENM-mediated immunomodulation and toxicity.