Bahri Abaylı1, Genco Gençdal2, Şerife Değirmencioğlu3. 1. Department of Gastroenterology and Hepatology, Cukurova Dr. Askım Tufekci Hospital, Adana, Turkey. 2. Center of Transplantation, Department of Gastroenterology and Hepatology, Yeni Yuzyıl, School of Medicine, İstanbul, Turkey. 3. Department of Internal Medicine, Yeni Yüzyıl University School of Medicine, Istanbul, Turkey.
Abstract
BACKGROUND: Acute pancreatitis (AP) is characterized by inflammation of the pancreas, elevated pancreatic enzymes, and abdominal pain. The neutrophil to lymphocyte ratio (NLR) is used as a marker of inflammation. In this retrospective study, we aimed to investigate novel early prognostic predictors of AP, such as NLR and its correlation with the Ranson score. METHODS: A total 435 patients (Male: 152; 34.9%, Age: 63.53 ± 17.22 years) were included in the study. Data were collected by two clinicians scanning the registered hospital records. RESULTS: Classification of the patients according to the aetiologies revealed gallstone(s) 58.6% (n = 255), hyperlipidaemia 2.2% (n = 9), viruses 0.7% (n = 3), malignancies 0.5% (n = 2), and alcohol 0.2% (n = 1). No reason was discovered in 37.9% (n = 165) of patients. Age, duration in the intensive care unit, serum aspartate aminotransferase (AST) levels, alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin, direct bilirubin, lactate dehydrogenase (LDH), white blood cell (WBC) count, neutrophil count, lymphocyte count, and the NLR were greater in the group with a Ranson score ≥3 than the group with a Ranson score <3. DISCUSSION: Quick diagnosis is essential in AP. Current scoring systems for AP diagnosis are complicated, whereas NLP is a simple, practical, and effective marker.
BACKGROUND: Acute pancreatitis (AP) is characterized by inflammation of the pancreas, elevated pancreatic enzymes, and abdominal pain. The neutrophil to lymphocyte ratio (NLR) is used as a marker of inflammation. In this retrospective study, we aimed to investigate novel early prognostic predictors of AP, such as NLR and its correlation with the Ranson score. METHODS: A total 435 patients (Male: 152; 34.9%, Age: 63.53 ± 17.22 years) were included in the study. Data were collected by two clinicians scanning the registered hospital records. RESULTS: Classification of the patients according to the aetiologies revealed gallstone(s) 58.6% (n = 255), hyperlipidaemia 2.2% (n = 9), viruses 0.7% (n = 3), malignancies 0.5% (n = 2), and alcohol 0.2% (n = 1). No reason was discovered in 37.9% (n = 165) of patients. Age, duration in the intensive care unit, serum aspartate aminotransferase (AST) levels, alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin, direct bilirubin, lactate dehydrogenase (LDH), white blood cell (WBC) count, neutrophil count, lymphocyte count, and the NLR were greater in the group with a Ranson score ≥3 than the group with a Ranson score <3. DISCUSSION: Quick diagnosis is essential in AP. Current scoring systems for AP diagnosis are complicated, whereas NLP is a simple, practical, and effective marker.
Authors: J Toouli; M Brooke-Smith; C Bassi; D Carr-Locke; J Telford; P Freeny; C Imrie; R Tandon Journal: J Gastroenterol Hepatol Date: 2002-02 Impact factor: 4.029
Authors: Aravind Suppiah; Deep Malde; Tameem Arab; Mazin Hamed; Victoria Allgar; Andrew M Smith; Gareth Morris-Stiff Journal: J Gastrointest Surg Date: 2013-02-01 Impact factor: 3.452
Authors: Basem Azab; Neil Jaglall; Jean Paul Atallah; Ari Lamet; Venkat Raja-Surya; Bachir Farah; Martin Lesser; Warren D Widmann Journal: Pancreatology Date: 2011-09-28 Impact factor: 3.996
Authors: F M Giardiello; A J Lazenby; T M Bayless; E J Levine; W B Bias; P W Ladenson; D F Hutcheon; N L Derevjanik; J H Yardley Journal: Dig Dis Sci Date: 1989-11 Impact factor: 3.199
Authors: M Stotz; A Gerger; F Eisner; J Szkandera; H Loibner; A L Ress; P Kornprat; W AlZoughbi; W A Zoughbi; F S Seggewies; C Lackner; T Stojakovic; H Samonigg; G Hoefler; M Pichler Journal: Br J Cancer Date: 2013-06-25 Impact factor: 9.075
Authors: M Pichler; G C Hutterer; C Stoeckigt; T F Chromecki; T Stojakovic; S Golbeck; K Eberhard; A Gerger; S Mannweiler; K Pummer; R Zigeuner Journal: Br J Cancer Date: 2013-02-05 Impact factor: 7.640