Cédric Galera1,2,3, Barbara Heude4,5, Anne Forhan4,5, Jonathan Y Bernard6, Hugo Peyre7,8, Judith Van der Waerden9,10, Laura Pryor9,10, Manuel-Pierre Bouvard1,3, Maria Melchior9,10, Sandrine Lioret4,5, Blandine de Lauzon-Guillain4,5. 1. Univ. Bordeaux, Bordeaux, France. 2. UMR1219, INSERM, Bordeaux, France. 3. Centre Hospitalier Perrens, Bordeaux, France. 4. UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), ORCHAD Team, INSERM, Paris, France. 5. Paris Descartes University, Paris, France. 6. Agency for Science, Technology and Research (A*STAR), Singapore Institute for Clinical Sciences, Singapore City, Singapore. 7. Laboratoire des Sciences Cognitives et Psycholinguistiques (ENS, EHESS, CNRS), Ecole Normale Supérieure, PSL Research University, Paris, France. 8. Department of Child and Adolescent Psychiatry, Robert Debré Hospital, APHP, Paris, France. 9. Social Epidemiology Research Group, Institut Pierre Louis d'Épidémiologie et de Santé Publique (IPLESP), INSERM UMR_S 1136, Paris, France. 10. Sorbonne Universités, UPMC Univ Paris 06, Paris, France.
Abstract
BACKGROUND: Evidence shows that diet contributes substantially to lifelong physical and mental health. Although dietary exposure during gestation and early postnatal life is critical, human epidemiological data are limited regarding its link with children's subsequent externalizing issues. The aim of this study was to investigate the role of maternal diet during pregnancy in offspring's symptoms of hyperactivity-inattention and conduct problems from ages 3 to 8 years. METHODS: We used data of 1,242 mother-child pairs from a French cohort followed up from pregnancy until the children were 8 years of age. Dietary patterns (DP) of the mother during pregnancy were assessed with food frequency questionnaires. Children's externalizing behavior was assessed with the Strength and Difficulties Questionnaire at ages 3, 5, and 8 years, from which trajectories of hyperactivity-inattention symptoms and conduct problems were derived. We conducted multivariable logistic models to study associations adjusted for a range of potential confounders. RESULTS: Results showed significant relationships between maternal 'low Healthy diet' (adjusted Odds Ratio (aOR) = 1.61; IC 95%: 1.09-2.37) and 'high Western diet' (aOR = 1.67; IC 95%: 1.13-2.47) during pregnancy and children's trajectories of high symptoms of hyperactivity-inattention. The associations took into account relevant confounders such as DP of the children at age 2 years, maternal stress and depression, gestational diabetes, and socioeconomic variables. CONCLUSIONS: Maternal diet during pregnancy was independently associated with children's hyperactivity-inattention symptoms but not with conduct problems. Early prevention addressing lifestyle should specifically target diet in pregnant women.
BACKGROUND: Evidence shows that diet contributes substantially to lifelong physical and mental health. Although dietary exposure during gestation and early postnatal life is critical, human epidemiological data are limited regarding its link with children's subsequent externalizing issues. The aim of this study was to investigate the role of maternal diet during pregnancy in offspring's symptoms of hyperactivity-inattention and conduct problems from ages 3 to 8 years. METHODS: We used data of 1,242 mother-child pairs from a French cohort followed up from pregnancy until the children were 8 years of age. Dietary patterns (DP) of the mother during pregnancy were assessed with food frequency questionnaires. Children's externalizing behavior was assessed with the Strength and Difficulties Questionnaire at ages 3, 5, and 8 years, from which trajectories of hyperactivity-inattention symptoms and conduct problems were derived. We conducted multivariable logistic models to study associations adjusted for a range of potential confounders. RESULTS: Results showed significant relationships between maternal 'low Healthy diet' (adjusted Odds Ratio (aOR) = 1.61; IC 95%: 1.09-2.37) and 'high Western diet' (aOR = 1.67; IC 95%: 1.13-2.47) during pregnancy and children's trajectories of high symptoms of hyperactivity-inattention. The associations took into account relevant confounders such as DP of the children at age 2 years, maternal stress and depression, gestational diabetes, and socioeconomic variables. CONCLUSIONS: Maternal diet during pregnancy was independently associated with children's hyperactivity-inattention symptoms but not with conduct problems. Early prevention addressing lifestyle should specifically target diet in pregnant women.
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