Caihong Zhou1, Xiaoling Zhong2, Yongzhe Yang3, Wanqun Yang1, Lijuan Wang4, Yuhu Zhang4, Kun Nie4, Jianmin Xu2, Biao Huang5. 1. Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, China. 2. Department of Radiology, Shenzhen People's Hospital, 2nd Clinical Medical College of Jinan University, Shenzhen, China. 3. School of Medicine, South China University of Technology, Guangzhou, China. 4. Department of Neurology, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, China. 5. Department of Radiology, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangzhou, China. Electronic address: cjr.huangbiao@vip.163.com.
Abstract
INTRODUCTION: Freezing of gait (FOG) is a serious complication in patients with Parkinson's disease (PD), and is more common in the late state of the disease. The high risk of falling in patients with FOG impacts their quality of life. OBJECTIVE: To explore altered neuroactivity related to cognitive and executive function of PD patients with FOG. METHODS: Fourteen PD patients with FOG (FOG+), 20 PD patients without FOG (FOG-), and 18 normal controls (NC) were enrolled. Functional MRI data of all PD patients were collected during OFF medication state. Data were analyzed using software of DPARSF and REST. Resting brain activity was measured by regional homogeneity (ReHo). ANOVA test was performed for ReHo among FOG, PD, and NC groups. RESULTS: ReHo alterations of left supplementary motor area (SMA) (Brodmann 6), left superior frontal region (Brodmann 9), and the right putamen (Brodmann 48) were significantly different among the three groups. The ReHo values within left SMA (Brodmann 6) and left superior frontal region (Brodmann 9) were significantly decreased in FOG+ patients compared with FOG- patients. CONCLUSION: Changes in neural hypoactivity within the frontal region and SMA appear to be associated with FOG in PD patients, which suggests that the mechanism underlying FOG may relate to disruption of execution and cognition.
INTRODUCTION: Freezing of gait (FOG) is a serious complication in patients with Parkinson's disease (PD), and is more common in the late state of the disease. The high risk of falling in patients with FOG impacts their quality of life. OBJECTIVE: To explore altered neuroactivity related to cognitive and executive function of PDpatients with FOG. METHODS: Fourteen PDpatients with FOG (FOG+), 20 PDpatients without FOG (FOG-), and 18 normal controls (NC) were enrolled. Functional MRI data of all PDpatients were collected during OFF medication state. Data were analyzed using software of DPARSF and REST. Resting brain activity was measured by regional homogeneity (ReHo). ANOVA test was performed for ReHo among FOG, PD, and NC groups. RESULTS: ReHo alterations of left supplementary motor area (SMA) (Brodmann 6), left superior frontal region (Brodmann 9), and the right putamen (Brodmann 48) were significantly different among the three groups. The ReHo values within left SMA (Brodmann 6) and left superior frontal region (Brodmann 9) were significantly decreased in FOG+patients compared with FOG-patients. CONCLUSION: Changes in neural hypoactivity within the frontal region and SMA appear to be associated with FOG in PDpatients, which suggests that the mechanism underlying FOG may relate to disruption of execution and cognition.
Authors: Gilles Allali; Helena M Blumen; Hervé Devanne; Elvira Pirondini; Arnaud Delval; Dimitri Van De Ville Journal: Neurophysiol Clin Date: 2018-10-25 Impact factor: 3.734