Hidenobu Takagi1, Ryoichi Tanaka2, Kyohei Nagata3, Ryo Ninomiya4, Kazumasa Arakita5, Joanne D Schuijf6, Kunihiro Yoshioka7. 1. Department of Radiology, Iwate Medical University, 19-1, Uchimaru, Morioka, Iwate, Japan. Electronic address: hdnb69tkg@gmail.com. 2. Department of Radiology, Iwate Medical University, 19-1, Uchimaru, Morioka, Iwate, Japan. Electronic address: rtanaka@iwate-med-ac.jp. 3. Department of Cardiology, Iwate Medical University, 19-1, Uchimaru, Morioka, Iwate, Japan. Electronic address: rafty0711@gmail.com. 4. Department of Cardiology, Iwate Medical University, 19-1, Uchimaru, Morioka, Iwate, Japan. Electronic address: rnino0123@gmail.com. 5. Center for Medical Research and Development, Toshiba Medical Systems Corporation, 1385, Shimoishigami, Otawara, Japan. Electronic address: kazumasa.arakita@glb.toshiba.co.jp. 6. Center for Medical Research and Development Europe, Toshiba Medical Systems Europe, Zilverstraat 1, 2718 RP Zoetermeer, Netherlands. Electronic address: Joanne.Schuijf@toshiba-medical.eu. 7. Department of Radiology, Iwate Medical University, 19-1, Uchimaru, Morioka, Iwate, Japan. Electronic address: kyoshi@iwate-med.ac.jp.
Abstract
PURPOSE: Recently, ultra-high-resolution computed tomography (U-HRCT) with a 0.25 mm × 128-row detector was introduced. The purpose of this study was to evaluate the diagnostic performance of coronary CT angiography (CCTA) using U-HRCT. METHODS: This retrospective study included 38 consecutive patients with suspected coronary artery disease (CAD) who underwent CCTA with U-HRCT followed by invasive coronary angiography (ICA). Per-segment diameter stenosis was calculated. Diagnostic performance of CCTA relative to ICA as the reference standard was determined. For segments with >30% diameter stenosis, the correlation and agreement of percent diameter stenosis between CCTA and ICA were calculated. RESULTS: Obstructive CAD was observed in 65 segments (12%) of 51 vessels (45%) in 32 patients (84%) during ICA. The per-patient, vessel, and segment analyses showed a sensitivity of 100% (95% confidence interval [CI], 95%-100%), 96% (95% CI: 89%-99%) and 95% (95% CI: 89%-98%), respectively, and a specificity of 67% (95% CI: 38%-67%), 81% (95% CI: 75%-83%) and 96% (95% CI: 96%-97%), respectively. The percentage of diameter stenosis, as determined by CCTA, demonstrated an excellent correlation with ICA (R = 0.90; 95% CI: 0.83-0.95) and a slight significant overestimation (mean: 4% ± 7%, p < .01), with the agreed range of limits being ± 16%. The median effective radiation dose for CCTA was 5.4 mSv (range: 2.9-18.0 mSv). CONCLUSIONS: CCTA with U-HRCT demonstrated an excellent correlation and agreement with ICA in the quantification of coronary artery stenosis.
PURPOSE: Recently, ultra-high-resolution computed tomography (U-HRCT) with a 0.25 mm × 128-row detector was introduced. The purpose of this study was to evaluate the diagnostic performance of coronary CT angiography (CCTA) using U-HRCT. METHODS: This retrospective study included 38 consecutive patients with suspected coronary artery disease (CAD) who underwent CCTA with U-HRCT followed by invasive coronary angiography (ICA). Per-segment diameter stenosis was calculated. Diagnostic performance of CCTA relative to ICA as the reference standard was determined. For segments with >30% diameter stenosis, the correlation and agreement of percent diameter stenosis between CCTA and ICA were calculated. RESULTS: Obstructive CAD was observed in 65 segments (12%) of 51 vessels (45%) in 32 patients (84%) during ICA. The per-patient, vessel, and segment analyses showed a sensitivity of 100% (95% confidence interval [CI], 95%-100%), 96% (95% CI: 89%-99%) and 95% (95% CI: 89%-98%), respectively, and a specificity of 67% (95% CI: 38%-67%), 81% (95% CI: 75%-83%) and 96% (95% CI: 96%-97%), respectively. The percentage of diameter stenosis, as determined by CCTA, demonstrated an excellent correlation with ICA (R = 0.90; 95% CI: 0.83-0.95) and a slight significant overestimation (mean: 4% ± 7%, p < .01), with the agreed range of limits being ± 16%. The median effective radiation dose for CCTA was 5.4 mSv (range: 2.9-18.0 mSv). CONCLUSIONS:CCTA with U-HRCT demonstrated an excellent correlation and agreement with ICA in the quantification of coronary artery stenosis.