| Literature DB >> 29569826 |
Yi Ma1, Zhaohui Wang1, Yuxuan Ma1, Zhihao Han1, Min Zhang1, Haiyan Chen1, Yueqing Gu1.
Abstract
A telomerase-responsive DNA icosahedron was designed to precisely release caged platinum nanodrugs into cisplatin-resistance tumor cells for effective therapy. This DNA icosahedron was constructed from two pyramidal DNA cages connected with telomerase primers and telomeric repeats, and platinum nanodrugs were then encapsulated into the DNA structure. In the presence of telomerase, the primers are extended, leading to inner-chain substitution of the DNA icosahedron and subsequent release of the caged nanodrugs. This DNA icosahedron can precisely release caged nanodrugs in response to telomerase in tumor cells, giving enhanced anticancer efficacy in drug-resistant carcinoma and with reduced toxicity to normal tissues. We speculate that this precisely designed, well controlled DNA cage could be generalized to diverse anticancer drugs.Entities:
Keywords: DNA nanotechnology; antitumor agents; controlled release; drug resistance; telomerase
Mesh：
Substances：
Year: 2018 PMID： 29569826 DOI： 10.1002/anie.201801195
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336