Masoud Hatefi1, Mohammad Reza Hafezi Ahmadi2, Asghar Rahmani3, Masoud Moghadas Dastjerdi4, Khairollah Asadollahi5. 1. Department of Neurosurgery, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. 2. Department of Pathology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. 3. Student Research Committee, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. 4. Department of Emergency Medicine, Faculty of Medicine, Esfahan University of Medical Sciences, Isfahan, Iran. 5. Department of Social Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran. Electronic address: masoud_1241@yahoo.co.uk.
Abstract
BACKGROUND: Osteoporosis is one of the most common problems of patients with spinal cord injuries (SCIs). The current study aimed to evaluate the antiosteoporotic effects of curcumin on densitometry parameters and biomarkers of bone turnovers among patients with SCI. MATERIALS AND METHODS: The current controlled clinical trial was conducted among 100 patients with SCI referred to an outpatient clinic of rehabilitation in Ilam City, Iran, in 2013-2015. The intervention group received 110/mg/kg/day curcumin for 6 months and the control group received placebo. Bone mineral density (BMD) was measured in all patients. The level of procollagen type I N-terminal propeptide, serum carboxy-terminal telopeptide of type I collagen, osteocalcin, and bone-specific alkaline phosphates were compared before and after study. RESULTS:BMD indicators of lumbar, femoral neck, and total hip in the control group significantly decreased compared with the beginning of study. However, in the curcumin group, a significant increase was observed in BMD indicators of lumbar, femoral neck, and hip at the end of study compared with the beginning. There was also a significant difference between interventional and control groups for the mean BMD of femoral neck and hip at the end of study (0.718 ± 0.002 g/cm2 vs. 0.712 ± 0.003 g/cm2 and 0.742 ± 0.031 g/cm2 vs. 0.692 ± 0.016 g/cm2, respectively). CONCLUSIONS:Curcumin, via modulation of densitometry indices and bone resorption markers, showed inhibitory effects on the process of osteoporosis. Treatment with curcumin was significantly associated with a decrease in the osteoporosis progression and bone turnover markers of patients with SCI after 6 months.
RCT Entities:
BACKGROUND:Osteoporosis is one of the most common problems of patients with spinal cord injuries (SCIs). The current study aimed to evaluate the antiosteoporotic effects of curcumin on densitometry parameters and biomarkers of bone turnovers among patients with SCI. MATERIALS AND METHODS: The current controlled clinical trial was conducted among 100 patients with SCI referred to an outpatient clinic of rehabilitation in Ilam City, Iran, in 2013-2015. The intervention group received 110/mg/kg/day curcumin for 6 months and the control group received placebo. Bone mineral density (BMD) was measured in all patients. The level of procollagen type I N-terminal propeptide, serum carboxy-terminal telopeptide of type I collagen, osteocalcin, and bone-specific alkaline phosphates were compared before and after study. RESULTS: BMD indicators of lumbar, femoral neck, and total hip in the control group significantly decreased compared with the beginning of study. However, in the curcumin group, a significant increase was observed in BMD indicators of lumbar, femoral neck, and hip at the end of study compared with the beginning. There was also a significant difference between interventional and control groups for the mean BMD of femoral neck and hip at the end of study (0.718 ± 0.002 g/cm2 vs. 0.712 ± 0.003 g/cm2 and 0.742 ± 0.031 g/cm2 vs. 0.692 ± 0.016 g/cm2, respectively). CONCLUSIONS:Curcumin, via modulation of densitometry indices and bone resorption markers, showed inhibitory effects on the process of osteoporosis. Treatment with curcumin was significantly associated with a decrease in the osteoporosis progression and bone turnover markers of patients with SCI after 6 months.
Authors: Andrew G Kunihiro; Paula B Luis; Julia A Brickey; Jen B Frye; H-H Sherry Chow; Claus Schneider; Janet L Funk Journal: J Nat Prod Date: 2019-02-22 Impact factor: 4.050
Authors: Hanie Kheiridoost-Langaroodi; Seyed Kazem Shakouri; Mahdi Amirpour; Amir Mehdi Iranshahi; Azizeh Farshbaf-Khalili Journal: J Family Reprod Health Date: 2022-03