Literature DB >> 29563134

Are Metabolic Signatures Mediating the Relationship between Lifestyle Factors and Hepatocellular Carcinoma Risk? Results from a Nested Case-Control Study in EPIC.

Nada Assi1, Duncan C Thomas2, Michael Leitzmann3, Magdalena Stepien1, Véronique Chajès1, Thierry Philip4, Paolo Vineis5, Christina Bamia6,7, Marie-Christine Boutron-Ruault8,9, Torkjel M Sandanger10, Amaia Molinuevo11,12, Hendriek C Boshuizen13, Anneli Sundkvist14, Tilman Kühn15, Ruth C Travis16, Kim Overvad17, Elio Riboli5, Marc J Gunter1, Augustin Scalbert1, Mazda Jenab1, Pietro Ferrari18, Vivian Viallon1,19.   

Abstract

Background: The "meeting-in-the-middle" (MITM) is a principle to identify exposure biomarkers that are also predictors of disease. The MITM statistical framework was applied in a nested case-control study of hepatocellular carcinoma (HCC) within European Prospective Investigation into Cancer and Nutrition (EPIC), where healthy lifestyle index (HLI) variables were related to targeted serum metabolites.
Methods: Lifestyle and targeted metabolomic data were available from 147 incident HCC cases and 147 matched controls. Partial least squares analysis related 7 lifestyle variables from a modified HLI to a set of 132 serum-measured metabolites and a liver function score. Mediation analysis evaluated whether metabolic profiles mediated the relationship between each lifestyle exposure and HCC risk.
Results: Exposure-related metabolic signatures were identified. Particularly, the body mass index (BMI)-associated metabolic component was positively related to glutamic acid, tyrosine, PC aaC38:3, and liver function score and negatively to lysoPC aC17:0 and aC18:2. The lifetime alcohol-specific signature had negative loadings on sphingomyelins (SM C16:1, C18:1, SM(OH) C14:1, C16:1 and C22:2). Both exposures were associated with increased HCC with total effects (TE) = 1.23 (95% confidence interval = 0.93-1.62) and 1.40 (1.14-1.72), respectively, for BMI and alcohol consumption. Both metabolic signatures mediated the association between BMI and lifetime alcohol consumption and HCC with natural indirect effects, respectively, equal to 1.56 (1.24-1.96) and 1.09 (1.03-1.15), accounting for a proportion mediated of 100% and 24%.Conclusions: In a refined MITM framework, relevant metabolic signatures were identified as mediators in the relationship between lifestyle exposures and HCC risk.Impact: The understanding of the biological basis for the relationship between modifiable exposures and cancer would pave avenues for clinical and public health interventions on metabolic mediators. Cancer Epidemiol Biomarkers Prev; 27(5); 531-40. ©2018 AACR. ©2018 American Association for Cancer Research.

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Year:  2018        PMID： 29563134      PMCID： PMC7444360          DOI： 10.1158/1055-9965.EPI-17-0649

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  77 in total

Review 1.  Pilot phase studies on the accuracy of dietary intake measurements in the EPIC project: overall evaluation of results. European Prospective Investigation into Cancer and Nutrition.

Authors:  R Kaaks; N Slimani; E Riboli
Journal:  Int J Epidemiol       Date:  1997       Impact factor: 7.196

2.  Mediation Analysis With Matched Case-Control Study Designs.

Authors:  Tyler J VanderWeele; Eric J Tchetgen Tchetgen
Journal:  Am J Epidemiol       Date:  2016-04-13       Impact factor: 4.897

3.  Cardiovascular Risk Factors Associated With Blood Metabolite Concentrations and Their Alterations During a 4-Year Period in a Population-Based Cohort.

Authors:  Maria Elena Lacruz; Alexander Kluttig; Daniel Tiller; Daniel Medenwald; Ina Giegling; Dan Rujescu; Cornelia Prehn; Jerzy Adamski; Stefan Frantz; Karin Halina Greiser; Rebecca Thwing Emeny; Gabi Kastenmüller; Johannes Haerting
Journal:  Circ Cardiovasc Genet       Date:  2016-10-26

Review 4.  Measuring the exposome: a powerful basis for evaluating environmental exposures and cancer risk.

Authors:  Christopher P Wild; Augustin Scalbert; Zdenko Herceg
Journal:  Environ Mol Mutagen       Date:  2013-05-16       Impact factor: 3.216

5.  A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study.

Authors:  Nada Assi; Anne Fages; Paolo Vineis; Marc Chadeau-Hyam; Magdalena Stepien; Talita Duarte-Salles; Graham Byrnes; Houda Boumaza; Sven Knüppel; Tilman Kühn; Domenico Palli; Christina Bamia; Hendriek Boshuizen; Catalina Bonet; Kim Overvad; Mattias Johansson; Ruth Travis; Marc J Gunter; Eiliv Lund; Laure Dossus; Bénédicte Elena-Herrmann; Elio Riboli; Mazda Jenab; Vivian Viallon; Pietro Ferrari
Journal:  Mutagenesis       Date:  2015-06-30       Impact factor: 3.000

6.  Untargeted metabolic profiling identifies altered serum metabolites of type 2 diabetes mellitus in a prospective, nested case control study.

Authors:  Dagmar Drogan; Warwick B Dunn; Wanchang Lin; Brian Buijsse; Matthias B Schulze; Claudia Langenberg; Marie Brown; Anna Floegel; Stefan Dietrich; Olov Rolandsson; David C Wedge; Royston Goodacre; Nita G Forouhi; Stephen J Sharp; Joachim Spranger; Nick J Wareham; Heiner Boeing
Journal:  Clin Chem       Date:  2014-12-18       Impact factor: 8.327

7.  Tyrosine levels are associated with insulin resistance in patients with nonalcoholic fatty liver disease.

Authors:  Miwa Kawanaka; Ken Nishino; Takahito Oka; Noriyo Urata; Jun Nakamura; Mitsuhiko Suehiro; Hirofumi Kawamoto; Yasutaka Chiba; Gotaro Yamada
Journal:  Hepat Med       Date:  2015-06-03

8.  Linking diet, physical activity, cardiorespiratory fitness and obesity to serum metabolite networks: findings from a population-based study.

Authors:  A Floegel; A Wientzek; U Bachlechner; S Jacobs; D Drogan; C Prehn; J Adamski; J Krumsiek; M B Schulze; T Pischon; H Boeing
Journal:  Int J Obes (Lond)       Date:  2014-03-10       Impact factor: 5.095

9.  Healthy Lifestyle and Risk of Cancer in the European Prospective Investigation Into Cancer and Nutrition Cohort Study.

Authors:  Fiona McKenzie; Carine Biessy; Pietro Ferrari; Heinz Freisling; Sabina Rinaldi; Veronique Chajès; Christina C Dahm; Kim Overvad; Laure Dossus; Pagona Lagiou; Dimitrios Trichopoulos; Antonia Trichopoulou; H Bas Bueno-de-Mesquita; Anne May; Petra H Peeters; Elisabete Weiderpass; Maria-Jose Sanchez; Carmen Navarro; Eva Ardanaz; Ulrika Ericson; Elisabet Wirfält; Ruth C Travis; Isabelle Romieu
Journal:  Medicine (Baltimore)       Date:  2016-04       Impact factor: 1.889

10.  Associations of anthropometric markers with serum metabolites using a targeted metabolomics approach: results of the EPIC-potsdam study.

Authors:  U Bachlechner; A Floegel; A Steffen; C Prehn; J Adamski; T Pischon; H Boeing
Journal:  Nutr Diabetes       Date:  2016-06-27       Impact factor: 5.097
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  5 in total

1.  Mediation analysis of the alcohol-postmenopausal breast cancer relationship by sex hormones in the EPIC cohort.

Authors:  Nada Assi; Sabina Rinaldi; Vivian Viallon; S Ghazaleh Dashti; Laure Dossus; Agnès Fournier; Iris Cervenka; Marina Kvaskoff; Renée Turzanski-Fortner; Manuela Bergmann; Heiner Boeing; Salvatore Panico; Fulvio Ricceri; Domenico Palli; Rosario Tumino; Sara Grioni; María José Sánchez Pérez; María-Dolores Chirlaque; Catalina Bonet; Aurelio Barricarte Gurrea; Pilar Amiano Etxezarreta; Susana Merino; H Bas Bueno de Mesquita; Carla H van Gils; Charlotte Onland-Moret; Anne Tjønneland; Kim Overvad; Antonia Trichopoulou; Georgia Martimianaki; Anna Karakatsani; Tim Key; Sofia Christakoudi; Merete Ellingjord-Dale; Kostas Tsilidis; Elio Riboli; Rudolf Kaaks; Marc J Gunter; Pietro Ferrari
Journal:  Int J Cancer       Date:  2019-04-30       Impact factor: 7.396

Review 2.  Nutritional Metabolomics in Cancer Epidemiology: Current Trends, Challenges, and Future Directions.

Authors:  Emma E McGee; Rama Kiblawi; Mary C Playdon; A Heather Eliassen
Journal:  Curr Nutr Rep       Date:  2019-09

3.  Metabolic signatures of greater body size and their associations with risk of colorectal and endometrial cancers in the European Prospective Investigation into Cancer and Nutrition.

Authors:  Nathalie Kliemann; Vivian Viallon; Neil Murphy; Rebecca J Beeken; Joseph A Rothwell; Sabina Rinaldi; Nada Assi; Eline H van Roekel; Julie A Schmidt; Kristin Benjaminsen Borch; Claudia Agnoli; Ann H Rosendahl; Hanna Sartor; José María Huerta; Anne Tjønneland; Jytte Halkjær; Bas Bueno-de-Mesquita; Audrey Gicquiau; David Achaintre; Krasimira Aleksandrova; Matthias B Schulze; Alicia K Heath; Konstantinos K Tsilidis; Giovanna Masala; Salvatore Panico; Rudolf Kaaks; Renée T Fortner; Bethany Van Guelpen; Laure Dossus; Augustin Scalbert; Hector C Keun; Ruth C Travis; Mazda Jenab; Mattias Johansson; Pietro Ferrari; Marc J Gunter
Journal:  BMC Med       Date:  2021-04-30       Impact factor: 8.775

4.  Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort.

Authors:  Mathilde His; Vivian Viallon; Laure Dossus; Julie A Schmidt; Ruth C Travis; Marc J Gunter; Kim Overvad; Cecilie Kyrø; Anne Tjønneland; Lucie Lécuyer; Joseph A Rothwell; Gianluca Severi; Theron Johnson; Verena Katzke; Matthias B Schulze; Giovanna Masala; Sabina Sieri; Salvatore Panico; Rosario Tumino; Alessandra Macciotta; Jolanda M A Boer; Evelyn M Monninkhof; Karina Standahl Olsen; Therese H Nøst; Torkjel M Sandanger; Antonio Agudo; Maria-Jose Sánchez; Pilar Amiano; Sandra M Colorado-Yohar; Eva Ardanaz; Linda Vidman; Anna Winkvist; Alicia K Heath; Elisabete Weiderpass; Inge Huybrechts; Sabina Rinaldi
Journal:  BMC Med       Date:  2021-12-10       Impact factor: 8.775

5.  Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium.

Authors:  Anne J M R Geijsen; Eline H van Roekel; Fränzel J B van Duijnhoven; David Achaintre; Thomas Bachleitner-Hofmann; Andreas Baierl; Michael M Bergmann; Jürgen Boehm; Martijn J L Bours; Hermann Brenner; Stéphanie O Breukink; Stefanie Brezina; Jenny Chang-Claude; Esther Herpel; Johannes H W de Wilt; Audrey Gicquiau; Biljana Gigic; Tanja Gumpenberger; Bibi M E Hansson; Michael Hoffmeister; Andreana N Holowatyj; Judith Karner-Hanusch; Pekka Keski-Rahkonen; Eric T P Keulen; Janna L Koole; Gernot Leeb; Jennifer Ose; Peter Schirmacher; Martin A Schneider; Petra Schrotz-King; Anton Stift; Arve Ulvik; F Jeroen Vogelaar; Evertine Wesselink; Moniek van Zutphen; Andrea Gsur; Nina Habermann; Ellen Kampman; Augustin Scalbert; Per M Ueland; Alexis B Ulrich; Cornelia M Ulrich; Matty P Weijenberg; Dieuwertje E Kok
Journal:  Int J Cancer       Date:  2019-10-10       Impact factor: 7.396
  5 in total

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