Chris Baeken1, Romain Duprat2, Guo-Rong Wu3, Rudi De Raedt4, Kees van Heeringen5. 1. Department of Psychiatry and Medical Psychology, Ghent University, Ghent; Ghent Experimental Psychiatry Lab, Ghent University, Ghent; Department of Psychiatry, University Hospital, Brussels, Belgium. Electronic address: cbaeken@hotmail.com. 2. Department of Psychiatry and Medical Psychology, Ghent University, Ghent; Ghent Experimental Psychiatry Lab, Ghent University, Ghent. 3. Department of Psychiatry and Medical Psychology, Ghent University, Ghent; Ghent Experimental Psychiatry Lab, Ghent University, Ghent; Key Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China. 4. Department of Experimental Clinical and Health Psychology, Ghent University, Ghent. 5. Department of Psychiatry and Medical Psychology, Ghent University, Ghent.
Abstract
BACKGROUND: Accelerated repetitive transcranial magnetic stimulation paradigms have been shown to result in fast decreases in depressive symptoms and suicidal ideation. Although the subgenual anterior cingulate cortex (sgACC) region has been put forward as a possible biological marker, so far, no studies evaluated the clinical effects of accelerated intermittent theta burst stimulation (aiTBS) on sgACC functional connectivity (FC). METHODS:Fifty patients with treatment-resistant depression were enrolled in this registered randomized double-blind sham-controlled crossover aiTBS treatment study. All received 20 iTBS sessions applied to the left dorsolateral prefrontal cortex (5 daily sessions spread over 4 days). Forty-four complete resting-state functional magnetic resonance imaging scans were collected. Baseline resting-state functional magnetic resonance imaging scans were compared with a matched healthy control group. Besides depression severity, all patients were also assessed with the Scale for Suicide Ideation and the Beck Hopelessness Scale. RESULTS: Our main resting-state functional magnetic resonance imaging findings indicate that a positive sgACC FC correlation with the medial orbitofrontal cortex could distinguish aiTBS responders from nonresponders at baseline. Beneficial aiTBS treatment strengthened sgACC-medial orbitofrontal cortex FC patterns. Moreover, this increased FC pattern was associated with a decrease in feelings of hopelessness. CONCLUSIONS: Clinical response to aiTBS treatment is not only characterized by stronger FC patterns between the sgACC and the medial orbitofrontal cortex, but it is also associated with decreases in hopelessness. Our observations provide a possible neurobiological explanation why accelerated repetitive transcranial magnetic stimulation paradigms may result in prompt attenuation of negative thinking in depressed patients.
RCT Entities:
BACKGROUND: Accelerated repetitive transcranial magnetic stimulation paradigms have been shown to result in fast decreases in depressive symptoms and suicidal ideation. Although the subgenual anterior cingulate cortex (sgACC) region has been put forward as a possible biological marker, so far, no studies evaluated the clinical effects of accelerated intermittent theta burst stimulation (aiTBS) on sgACC functional connectivity (FC). METHODS: Fifty patients with treatment-resistant depression were enrolled in this registered randomized double-blind sham-controlled crossover aiTBS treatment study. All received 20 iTBS sessions applied to the left dorsolateral prefrontal cortex (5 daily sessions spread over 4 days). Forty-four complete resting-state functional magnetic resonance imaging scans were collected. Baseline resting-state functional magnetic resonance imaging scans were compared with a matched healthy control group. Besides depression severity, all patients were also assessed with the Scale for Suicide Ideation and the Beck Hopelessness Scale. RESULTS: Our main resting-state functional magnetic resonance imaging findings indicate that a positive sgACC FC correlation with the medial orbitofrontal cortex could distinguish aiTBS responders from nonresponders at baseline. Beneficial aiTBS treatment strengthened sgACC-medial orbitofrontal cortex FC patterns. Moreover, this increased FC pattern was associated with a decrease in feelings of hopelessness. CONCLUSIONS: Clinical response to aiTBS treatment is not only characterized by stronger FC patterns between the sgACC and the medial orbitofrontal cortex, but it is also associated with decreases in hopelessness. Our observations provide a possible neurobiological explanation why accelerated repetitive transcranial magnetic stimulation paradigms may result in prompt attenuation of negative thinking in depressedpatients.
Authors: A Irem Sonmez; Deniz Doruk Camsari; Aiswarya L Nandakumar; Jennifer L Vande Voort; Simon Kung; Charles P Lewis; Paul E Croarkin Journal: Psychiatry Res Date: 2018-12-07 Impact factor: 3.222
Authors: Robin F H Cash; Luca Cocchi; Rodney Anderson; Anton Rogachov; Aaron Kucyi; Alexander J Barnett; Andrew Zalesky; Paul B Fitzgerald Journal: Hum Brain Mapp Date: 2019-07-22 Impact factor: 5.038
Authors: Mehmet Utku Kucuker; Ammar G Almorsy; Ayse Irem Sonmez; Anna N Ligezka; Deniz Doruk Camsari; Charles P Lewis; Paul E Croarkin Journal: Front Hum Neurosci Date: 2021-06-25 Impact factor: 3.169
Authors: Deborah C W Klooster; Suzanne L Franklin; René M H Besseling; Jaap F A Jansen; Karen Caeyenberghs; Romain Duprat; Albert P Aldenkamp; Anton J A de Louw; Paul A J M Boon; Chris Baeken Journal: Hum Brain Mapp Date: 2018-10-01 Impact factor: 5.038