H David McIntyre1,2, Dorte M Jensen3,4,5, Richard C Jensen3,6,7, Henriette B Kyhl8,9, Tina K Jensen6,9,10, Dorte Glintborg3,5, Marianne Andersen3,5. 1. Mater Research and Mater Clinical Unit, The University of Queensland, South Brisbane, Queensland, Australia david.mcintyre@mater.org.au. 2. Danish Diabetes Academy, Odense University Hospital, Odense, Denmark. 3. Department of Endocrinology, Odense University Hospital, Odense, Denmark. 4. Department of Gynecology and Obstetrics, Odense University Hospital, Odense, Denmark. 5. Department of Clinical Research, University of Southern Denmark, Odense, Denmark. 6. Department of Environmental Medicine, Odense University Hospital, Odense, Denmark. 7. Department of Public Health, University of Southern Denmark, Odense, Denmark. 8. Odense Child Cohort, Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark. 9. Odense Patient data Explorative Network, Odense, Denmark. 10. Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Abstract
OBJECTIVE: To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort. RESEARCH DESIGN AND METHODS: This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria. FVPG measured at 28 weeks' gestation was related to pregnancy outcomes. RESULTS: With use of the World Health Organization (WHO) 2013 threshold of FVPG ≥5.1 mmol/L, 40.1% of the cohort qualified as having GDM. There was no evidence of excess fetal growth, hypertension in pregnancy, or cesarean delivery in women with FVPG <5.6 mmol/L. CONCLUSIONS: The WHO 2013 FVPG threshold for GDM is unsuitable for Denmark. It inappropriately labels as having GDM an unmanageably large number of women who are at low absolute risk of pregnancy complications.
OBJECTIVE: To define the prevalence and pregnancy outcomes related to elevated fasting venous plasma glucose (FVPG) in a Danish pregnancy cohort. RESEARCH DESIGN AND METHODS: This was an observational cohort study including 1,516 women without gestational diabetes mellitus (GDM) by Danish criteria. FVPG measured at 28 weeks' gestation was related to pregnancy outcomes. RESULTS: With use of the World Health Organization (WHO) 2013 threshold of FVPG ≥5.1 mmol/L, 40.1% of the cohort qualified as having GDM. There was no evidence of excess fetal growth, hypertension in pregnancy, or cesarean delivery in women with FVPG <5.6 mmol/L. CONCLUSIONS: The WHO 2013 FVPG threshold for GDM is unsuitable for Denmark. It inappropriately labels as having GDM an unmanageably large number of women who are at low absolute risk of pregnancy complications.
Authors: Louise Groth Grunnet; Line Hjort; Daniel Thomas Minja; Omari Abdul Msemo; Sofie Lykke Møller; Rashmi B Prasad; Leif Groop; John Lusingu; Birgitte Bruun Nielsen; Christentze Schmiegelow; Ib Christian Bygbjerg; Dirk Lund Christensen Journal: Int J Environ Res Public Health Date: 2020-04-29 Impact factor: 3.390
Authors: Tina Ravnsborg; Sarah Svaneklink; Lise Lotte T Andersen; Martin R Larsen; Dorte M Jensen; Martin Overgaard Journal: PLoS One Date: 2019-03-27 Impact factor: 3.240