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Literature DB >> 2955742

In vitro activity of A-56268 (TE-031), a new macrolide antibiotic, compared with that of erythromycin and other antimicrobial agents.

S Floyd-Reising, J A Hindler, L S Young.

Abstract

A-56268 is a new macrolide antibiotic that resembles erythromycin in its spectrum of activity. A-56268 and erythromycin had identical activities against Streptococcus pyogenes, group B, C, and G streptococci, and viridans group streptococci. Erythromycin and A-56268 had similar activities against Staphylococcus aureus, coagulase-negative staphylococci, and group D enterococci. Like erythromycin, A-56268 was ineffective in inhibiting oxacillin-resistant S. aureus, oxacillin-resistant, coagulase-negative staphylococci, and penicillin-resistant viridans group streptococci. Haemophilus influenzae, Neisseria gonorrhoeae, and Legionella spp. were inhibited by A-56268 at concentrations similar to those of erythromycin.

Entities: Chemical Species

Mesh：

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Year: 1987 PMID： 2955742 PMCID： PMC174797 DOI： 10.1128/AAC.31.4.640

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

3 in total

1. In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria.

Authors: T Barlam; H C Neu
Journal: Antimicrob Agents Chemother Date: 1984-04 Impact factor: 5.191

2. In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs.

Authors: R N Jones; A L Barry; C Thornsberry
Journal: Antimicrob Agents Chemother Date: 1983-08 Impact factor: 5.191

3. Susceptibility of Legionella spp. to mycinamicin I and II and other macrolide antibiotics: effects of media composition and origin of organisms.

Authors: P H Edelstein; K A Pasiecznik; V K Yasui; R D Meyer
Journal: Antimicrob Agents Chemother Date: 1982-07 Impact factor: 5.191

3 in total

12 in total

10. Variability of clarithromycin and erythromycin susceptibility tests with Haemophilus influenzae in four different broth media and correlation with the standard disk diffusion test.

Authors: A L Barry; P B Fernandes; J H Jorgensen; C Thornsberry; D J Hardy; R N Jones
Journal: J Clin Microbiol Date: 1988-11 Impact factor: 5.948

In vitro activity of A-56268 (TE-031), a new macrolide antibiotic, compared with that of erythromycin and other antimicrobial agents.

1. In vitro comparison of the activity of RU 28965, a new macrolide, with that of erythromycin against aerobic and anaerobic bacteria.

2. In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs.

3. Susceptibility of Legionella spp. to mycinamicin I and II and other macrolide antibiotics: effects of media composition and origin of organisms.

1. Pharmacokinetics of a clarithromycin suspension administered via nasogastric tube to seriously ill patients.

2. In vitro activity of clarithromycin and its 14-hydroxy-metabolite against 203 strains of Haemophilus influenzae.

Review 3. New directions for macrolide antibiotics: structural modifications and in vitro activity.

4. In vitro activities of several new macrolide antibiotics against Mycobacterium avium complex.

Review 5. Treatment of Legionnaires' disease. Current recommendations.

Review 6. Clarithromycin clinical pharmacokinetics.

Review 7. Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential.

8. Comparative in vitro activity of clarithromycin. Spanish Collaborative Group.

Review 9. Update on clinical significance of coagulase-negative staphylococci.

10. Variability of clarithromycin and erythromycin susceptibility tests with Haemophilus influenzae in four different broth media and correlation with the standard disk diffusion test.