Noriko Numata1, Yoshiyuki Hirano2, Chihiro Sutoh3, Daisuke Matsuzawa2,3, Kotaro Takeda4, Rikukage Setsu3, Eiji Shimizu2,3, Michiko Nakazato5. 1. Research Center for Child Mental Development, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. n_numata@chiba-u.jp. 2. Research Center for Child Mental Development, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. 3. Department of Cognitive Behavioral Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan. 4. Faculty of Rehabilitation, School of Health Sciences, Fujita Health University, Toyoake, Japan. 5. Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan.
Abstract
PURPOSE: This study sought to identify the prefrontal cortex hemodynamic response that is dependent on cognitive performance in patients with bulimic disorders (BD), and investigate its association with personality characteristics. METHODS: Nineteen female patients with BD and 23 healthy women were recruited. Their personality characteristics related to eating disorders were examined using a self-reporting questionnaire, namely the eating disorder inventory-2 (EDI-2). Cerebral blood flow response in the prefrontal cortex during the digit span backward task (DSBT) was measured using near-infrared spectroscopy (NIRS). Change in oxygenated hemoglobin concentration (ΔoxyHb), obtained using NIRS, were used as an index of brain activity. Further, the relationship between prefrontal cortical activity and personality characteristics was investigated in patients with BD. RESULTS: The cognitive performance of patients with BD was significantly lower in the DSBT compared with healthy subjects. There was no difference between the groups in ΔoxyHb during the task. Task scores of patients with BD correlated with asceticism and perfectionism. Moreover, the asceticism score was negatively correlated with ΔoxyHb of the bilateral prefrontal cortex in patients with BD. CONCLUSION: The results suggest that cognitive performance and brain activity induced during DSBT might be affected by asceticism in BD patients. LEVEL OF EVIDENCE: III, case-control study.
PURPOSE: This study sought to identify the prefrontal cortex hemodynamic response that is dependent on cognitive performance in patients with bulimic disorders (BD), and investigate its association with personality characteristics. METHODS: Nineteen female patients with BD and 23 healthy women were recruited. Their personality characteristics related to eating disorders were examined using a self-reporting questionnaire, namely the eating disorder inventory-2 (EDI-2). Cerebral blood flow response in the prefrontal cortex during the digit span backward task (DSBT) was measured using near-infrared spectroscopy (NIRS). Change in oxygenated hemoglobin concentration (ΔoxyHb), obtained using NIRS, were used as an index of brain activity. Further, the relationship between prefrontal cortical activity and personality characteristics was investigated in patients with BD. RESULTS: The cognitive performance of patients with BD was significantly lower in the DSBT compared with healthy subjects. There was no difference between the groups in ΔoxyHb during the task. Task scores of patients with BD correlated with asceticism and perfectionism. Moreover, the asceticism score was negatively correlated with ΔoxyHb of the bilateral prefrontal cortex in patients with BD. CONCLUSION: The results suggest that cognitive performance and brain activity induced during DSBT might be affected by asceticism in BD patients. LEVEL OF EVIDENCE: III, case-control study.
Authors: Phillipa Hay; David Chinn; David Forbes; Sloane Madden; Richard Newton; Lois Sugenor; Stephen Touyz; Warren Ward Journal: Aust N Z J Psychiatry Date: 2014-11 Impact factor: 5.744
Authors: Jennifer J Thomas; Kamryn T Eddy; Helen B Murray; Marilou D P Tromp; Andrea S Hartmann; Melissa T Stone; Philip G Levendusky; Anne E Becker Journal: Psychiatry Res Date: 2015-06-27 Impact factor: 3.222