Cathrin Rohleder1,2, Dagmar Koethe3,4, Stefan Fritze1, Cristina E Topor1, F Markus Leweke1,4, Dusan Hirjak5. 1. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159, Mannheim, Germany. 2. Institute of Radiochemistry and Experimental Molecular Imaging, University Hospital of Cologne, Cologne, Germany. 3. Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. 4. Brain and Mind Centre, University of Sydney, Sydney, Australia. 5. Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159, Mannheim, Germany. dusan.hirjak@zi-mannheim.de.
Abstract
OBJECTIVES: Binocular depth inversion illusion (BDII), a visual, 'top-down'-driven information process, is impaired in schizophrenia and particularly in its early stages. BDII is a sensitive measure of impaired visual information processing and represents a valid diagnostic tool for schizophrenia and other psychotic disorders. However, neurobiological underpinnings of aberrant BDII in first-episode schizophrenia are largely unknown at present. METHODS: In this study, 22 right-handed, first-episode, antipsychotic-naïve schizophrenia patients underwent BDII assessment and MRI scanning at 1.5 T. The surface-based analysis via new version of Freesurfer (6.0) enabled calculation of cortical thickness and surface area. BDII total and faces scores were related to the two distinct cortical measurements. RESULTS: We found a significant correlation between BDII performance and cortical thickness in the inferior frontal gyrus and middle temporal gyrus (p < 0.003, Bonferroni corr.), as well as superior parietal gyrus, postcentral gyrus, supramarginal gyrus, and precentral gyrus (p < 0.05, CWP corr.), respectively. BDII performance was significantly correlated with surface area in the superior parietal gyrus and right postcentral gyrus (p < 0.003, Bonferroni corr.). CONCLUSION: BDII performance may be linked to cortical thickness and surface area variations in regions involved in "adaptive" or "top-down" modulation and stimulus processing, i.e., frontal and parietal lobes. Our results suggest that cortical features of distinct evolutionary and genetic origin differently contribute to BDII performance in first-episode, antipsychotic-naïve schizophrenia patients.
OBJECTIVES: Binocular depth inversion illusion (BDII), a visual, 'top-down'-driven information process, is impaired in schizophrenia and particularly in its early stages. BDII is a sensitive measure of impaired visual information processing and represents a valid diagnostic tool for schizophrenia and other psychotic disorders. However, neurobiological underpinnings of aberrant BDII in first-episode schizophrenia are largely unknown at present. METHODS: In this study, 22 right-handed, first-episode, antipsychotic-naïve schizophreniapatients underwent BDII assessment and MRI scanning at 1.5 T. The surface-based analysis via new version of Freesurfer (6.0) enabled calculation of cortical thickness and surface area. BDII total and faces scores were related to the two distinct cortical measurements. RESULTS: We found a significant correlation between BDII performance and cortical thickness in the inferior frontal gyrus and middle temporal gyrus (p < 0.003, Bonferroni corr.), as well as superior parietal gyrus, postcentral gyrus, supramarginal gyrus, and precentral gyrus (p < 0.05, CWP corr.), respectively. BDII performance was significantly correlated with surface area in the superior parietal gyrus and right postcentral gyrus (p < 0.003, Bonferroni corr.). CONCLUSION: BDII performance may be linked to cortical thickness and surface area variations in regions involved in "adaptive" or "top-down" modulation and stimulus processing, i.e., frontal and parietal lobes. Our results suggest that cortical features of distinct evolutionary and genetic origin differently contribute to BDII performance in first-episode, antipsychotic-naïve schizophreniapatients.
Authors: Filip Scheperjans; Christian Grefkes; Nicola Palomero-Gallagher; Axel Schleicher; Karl Zilles Journal: Neuroimage Date: 2005-04-15 Impact factor: 6.556
Authors: Wi Hoon Jung; June Sic Kim; Joon Hwan Jang; Jung-Seok Choi; Myung Hun Jung; Ji-Young Park; Ji Yeon Han; Chi-Hoon Choi; Do-Hyung Kang; Chun Kee Chung; Jun Soo Kwon Journal: Schizophr Bull Date: 2009-12-21 Impact factor: 9.306
Authors: C Christoph Schultz; Igor Nenadic; Kathrin Koch; Gerd Wagner; Martin Roebel; Claudia Schachtzabel; Thomas W Mühleisen; Markus M Nöthen; Sven Cichon; Thomas Deufel; Michael Kiehntopf; Marcella Rietschel; Jürgen R Reichenbach; Heinrich Sauer; Ralf G M Schlösser Journal: Neuropsychopharmacology Date: 2011-04-20 Impact factor: 7.853
Authors: Danai Dima; Jonathan P Roiser; Detlef E Dietrich; Catharina Bonnemann; Heinrich Lanfermann; Hinderk M Emrich; Wolfgang Dillo Journal: Neuroimage Date: 2009-03-24 Impact factor: 6.556
Authors: Dusan Hirjak; Robert C Wolf; Marie-Luise Otte; Mike M Schmitgen; Katharina M Kubera; Nadine D Wolf; Stefan Fritze; Lena S Geiger; Heike Tost; Ulrich W Seidl; Andreas Meyer-Lindenberg Journal: Eur Arch Psychiatry Clin Neurosci Date: 2021-09-13 Impact factor: 5.760