Literature DB >> 29552395

In vivo imaging-guided microsurgery based on femtosecond laser produced new fluorescent compounds in biological tissues.

Qiqi Sun1,2, Zhongya Qin1,2, Wanjie Wu1, Yue Lin3, Congping Chen1, Sicong He1, Xuesong Li1, Zhenguo Wu4,5, Yi Luo3, Jianan Y Qu1,5.   

Abstract

Femtosecond laser microsurgery has become an advanced method for clinical procedures and biological research. The tissue treated by femtosecond laser can become highly fluorescent, indicating the formation of new fluorescent compounds that can naturally label the treated tissue site. We systematically characterized the fluorescence signals produced by femtosecond laser ablation in biological tissues in vivo. Our findings showed that they possess unique fluorescence properties and can be clearly differentiated from endogenous signals and major fluorescent proteins. We further demonstrated that the new fluorescent compounds can be used as in vivo labelling agent for biological imaging and guided laser microsurgery.

Keywords:  (170.3880) Medical and biological imaging; (180.4315) Nonlinear microscopy; (300.2530) Fluorescence, laser-induced; (300.6500) Spectroscopy, time-resolved

Year:  2018        PMID： 29552395      PMCID： PMC5854060          DOI： 10.1364/BOE.9.000581

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN： 2156-7085            Impact factor:   3.732


  18 in total

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3.  In-vivo intratissue ablation by nanojoule near-infrared femtosecond laser pulses.

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5.  Dynamics of femtosecond laser photo-modification of collagen fibers.

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6.  A general route to make non-conjugated linear polymers luminescent.

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7.  Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence.

Authors:  Dong Li; Wei Zheng; Jianan Y Qu
Journal:  Opt Lett       Date:  2008-10-15       Impact factor: 3.776

8.  Decrease in laser ablation threshold for epithelial tissue microsurgery in a living Drosophila embryo during dorsal closure.

Authors:  A K N Thayil; A Pereira; M Mathew; D Artigas; E Martín Blanco; P Loza-Alvarez
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9.  Chronic in vivo imaging in the mouse spinal cord using an implanted chamber.

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  6 in total

1.  New fluorescent compounds produced by femtosecond laser surgery in biological tissues: the mechanisms.

Authors:  Zhongya Qin; Qiqi Sun; Yue Lin; Sicong He; Xuesong Li; Congping Chen; Wanjie Wu; Yi Luo; Jianan Y Qu
Journal:  Biomed Opt Express       Date:  2018-06-26       Impact factor: 3.732

2.  Noninvasive two-photon optical biopsy of retinal fluorophores.

Authors:  Grazyna Palczewska; Jakub Boguslawski; Patrycjusz Stremplewski; Lukasz Kornaszewski; Jianye Zhang; Zhiqian Dong; Xiao-Xuan Liang; Enrico Gratton; Alfred Vogel; Maciej Wojtkowski; Krzysztof Palczewski
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-26       Impact factor: 11.205

3.  Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping.

Authors:  Zhongya Qin; Zhentao She; Congping Chen; Wanjie Wu; Jackie K Y Lau; Nancy Y Ip; Jianan Y Qu
Journal:  Nat Biotechnol       Date:  2022-06-13       Impact factor: 54.908

4.  Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window.

Authors:  Wanjie Wu; Sicong He; Junqiang Wu; Congping Chen; Xuesong Li; Kai Liu; Jianan Y Qu
Journal:  Nat Commun       Date:  2022-04-12       Impact factor: 14.919

5.  Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo.

Authors:  Zhongya Qin; Sicong He; Chao Yang; Jasmine Sum-Yee Yung; Congping Chen; Christopher Kai-Shun Leung; Kai Liu; Jianan Y Qu
Journal:  Light Sci Appl       Date:  2020-05-06       Impact factor: 17.782

6.  Probing Intracellular Dynamics Using Fluorescent Carbon Dots Produced by Femtosecond Laser In Situ.

Authors:  Artyom A Astafiev; Aleksander M Shakhov; Alina A Osychenko; Maria S Syrchina; Artashes V Karmenyan; Ulyana A Tochilo; Victor A Nadtochenko
Journal:  ACS Omega       Date:  2020-05-19
  6 in total

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