Jessie P Buckley1, Lesliam Quirós-Alcalá2, Susan L Teitelbaum3, Antonia M Calafat4, Mary S Wolff3, Stephanie M Engel5. 1. Departments of Environmental Health & Engineering and Epidemiology, Johns Hopkins University, Baltimore, MD, USA. Electronic address: jessie.buckley@jhu.edu. 2. Maryland Institute of Applied Environmental Health, School of Public Health, University of Maryland, College Park, USA; Pulmonary and Critical Care Division, Johns Hopkins School of Medicine, Baltimore, MD, USA. 3. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, USA. 4. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. 5. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Abstract
BACKGROUND: Prenatal environmental phenol and phthalate exposures may alter immune or inflammatory responses leading to respiratory and allergic disease. OBJECTIVES: We estimated associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic outcomes among children in the Mount Sinai Children's Environmental Health Study. METHODS: We quantified urinary biomarkers of benzophenone-3, bisphenol A, paradichlorobenzene (as 2,5-dichlorophenol), triclosan, and 10 phthalate metabolites in third trimester maternal samples and assessed asthma, wheeze, and atopic skin conditions via parent questionnaires at ages 6 and 7 years (n = 164 children with 240 observations). We used logistic regression to estimate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) per standard deviation difference in natural log biomarker concentrations and examined effect measure modification by child's sex. RESULTS: Associations of prenatal 2,5-dichlorophenol (all outcomes) and bisphenol A (asthma outcomes) were modified by child's sex, with increased odds of outcomes among boys but not girls. Among boys, ORs for asthma diagnosis per standard deviation difference in biomarker concentration were 3.00 (95% CI: 1.36, 6.59) for 2,5-dichlorophenol and 3.04 (95% CI: 1.38, 6.68) for bisphenol A. Wheeze in the past 12 months was inversely associated with low molecular weight phthalate metabolites among girls only (OR: 0.27, 95% CI: 0.13, 0.59) and with benzophenone-3 among all children (OR: 0.65, 95% CI: 0.44, 0.96). CONCLUSIONS: Prenatal bisphenol A and paradichlorobenzene exposures were associated with pediatric respiratory outcomes among boys. Future studies may shed light on biological mechanisms and potential sexually-dimorphic effects of select phenols and phthalates on respiratory disease development.
BACKGROUND: Prenatal environmental phenol and phthalate exposures may alter immune or inflammatory responses leading to respiratory and allergic disease. OBJECTIVES: We estimated associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic outcomes among children in the Mount Sinai Children's Environmental Health Study. METHODS: We quantified urinary biomarkers of benzophenone-3, bisphenol A, paradichlorobenzene (as 2,5-dichlorophenol), triclosan, and 10 phthalate metabolites in third trimester maternal samples and assessed asthma, wheeze, and atopic skin conditions via parent questionnaires at ages 6 and 7 years (n = 164 children with 240 observations). We used logistic regression to estimate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) per standard deviation difference in natural log biomarker concentrations and examined effect measure modification by child's sex. RESULTS: Associations of prenatal 2,5-dichlorophenol (all outcomes) and bisphenol A (asthma outcomes) were modified by child's sex, with increased odds of outcomes among boys but not girls. Among boys, ORs for asthma diagnosis per standard deviation difference in biomarker concentration were 3.00 (95% CI: 1.36, 6.59) for 2,5-dichlorophenol and 3.04 (95% CI: 1.38, 6.68) for bisphenol A. Wheeze in the past 12 months was inversely associated with low molecular weight phthalate metabolites among girls only (OR: 0.27, 95% CI: 0.13, 0.59) and with benzophenone-3 among all children (OR: 0.65, 95% CI: 0.44, 0.96). CONCLUSIONS: Prenatal bisphenol A and paradichlorobenzene exposures were associated with pediatric respiratory outcomes among boys. Future studies may shed light on biological mechanisms and potential sexually-dimorphic effects of select phenols and phthalates on respiratory disease development.
Authors: Allan C Just; Robin M Whyatt; Matthew S Perzanowski; Antonia M Calafat; Frederica P Perera; Inge F Goldstein; Qixuan Chen; Andrew G Rundle; Rachel L Miller Journal: Environ Health Perspect Date: 2012-06-26 Impact factor: 9.031
Authors: Hsiu Ying Ku; Pen Hua Su; Hui Ju Wen; Hai Lun Sun; Chien Jen Wang; Hsiao Yen Chen; Jouni J K Jaakkola; Shu-Li Wang Journal: PLoS One Date: 2015-04-13 Impact factor: 3.240
Authors: Kimberly Berger; Brenda Eskenazi; John Balmes; Nina Holland; Antonia M Calafat; Kim G Harley Journal: Environ Int Date: 2018-10-04 Impact factor: 9.621
Authors: Angelico Mendy; Pӓivi M Salo; Jesse Wilkerson; Lydia Feinstein; Kelly K Ferguson; Michael B Fessler; Peter S Thorne; Darryl C Zeldin Journal: Environ Res Date: 2019-11-22 Impact factor: 6.498
Authors: Kimberly Berger; Eric Coker; Stephen Rauch; Brenda Eskenazi; John Balmes; Katie Kogut; Nina Holland; Antonia M Calafat; Kim Harley Journal: Sci Total Environ Date: 2020-04-03 Impact factor: 7.963
Authors: Lesliam Quirós-Alcalá; Nadia N Hansel; Meredith McCormack; Antonia M Calafat; Xiaoyun Ye; Roger D Peng; Elizabeth C Matsui Journal: J Allergy Clin Immunol Date: 2020-07-28 Impact factor: 10.793