Literature DB >> 2955045

Cell surface T3 expression requires the presence of both alpha- and beta-chains of the T cell receptor.

T Saito, A Weiss, K C Gunter, E M Shevach, R N Germain.   

Abstract

We have identified a surface T3- Jurkat variant which has a defective alpha-chain but which possesses an intact beta-chain. The transfection of a functional mouse alpha-chain into this human T cell induces the expression of surface T3 molecules associated with mouse alpha-human beta-heterodimers detected by anticlonotypic antibodies. Treatment of the transfectant with anti-T3, anti-mouse Ti-alpha, or anti-human Ti-beta antibodies clears all Ti-T3 complexes from the surface. These results demonstrate that functional alpha- and beta-chains are both required for expression of T3 on the cell membrane, and that the Ti heterodimers present and associated with T3 on Jurkat cells involve only alpha- and beta-chains.

Entities:  

Mesh：

Substances：

Year:  1987        PMID： 2955045

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  16 in total

1.  Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

Authors:  F Hochstenbach; V David; S Watkins; M B Brenner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

2.  T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3zeta subunit of the T-cell antigen receptor complex.

Authors:  Joseph L Roberts; Jens Peter H Lauritsen; Myriah Cooney; Roberta E Parrott; Elisa O Sajaroff; Chan M Win; Michael D Keller; Jeffery H Carpenter; Juan Carabana; Michael S Krangel; Marcella Sarzotti; Xiao-Ping Zhong; David L Wiest; Rebecca H Buckley
Journal:  Blood       Date:  2006-12-14       Impact factor: 22.113

3.  Characterization of two human lymphoid cell lines producing human T-lymphotropic virus type I (HTLV-I) isolated from patients with HTLV-I-associated myelopathy or encephalopathy.

Authors:  J Iwata; T Oka; M Furihata; H Sonobe; K Matsubayashi; Y Uemura; I Miyoshi; Y Ohtsuki
Journal:  Arch Virol       Date:  1991       Impact factor: 2.574

4.  The gamma and epsilon subunits of the CD3 complex inhibit pre-Golgi degradation of newly synthesized T cell antigen receptors.

Authors:  T Wileman; G R Carson; M Concino; A Ahmed; C Terhorst
Journal:  J Cell Biol       Date:  1990-04       Impact factor: 10.539

5.  Quality control of integral membrane proteins by assembly-dependent membrane integration.

Authors:  Matthias J Feige; Linda M Hendershot
Journal:  Mol Cell       Date:  2013-08-08       Impact factor: 17.970

6.  Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice.

Authors:  P Mombaerts; C Terhorst; T Jacks; S Tonegawa; J Sancho
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-01       Impact factor: 11.205

7.  Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes.

Authors:  A Alcover; C Alberini; O Acuto; L K Clayton; C Transy; G C Spagnoli; P Moingeon; P Lopez; E L Reinherz
Journal:  EMBO J       Date:  1988-07       Impact factor: 11.598

8.  Role of the zeta chain in the expression of the T cell antigen receptor: genetic reconstitution studies.

Authors:  A M Weissman; S J Frank; D G Orloff; M Merćep; J D Ashwell; R D Klausner
Journal:  EMBO J       Date:  1989-12-01       Impact factor: 11.598

9.  Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.

Authors:  K P Kearse; J L Roberts; T I Munitz; D L Wiest; T Nakayama; A Singer
Journal:  EMBO J       Date:  1994-10-03       Impact factor: 11.598

10.  Surface expression of only gamma delta and/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains.

Authors:  T Saito; F Hochstenbach; S Marusic-Galesic; A M Kruisbeek; M Brenner; R N Germain
Journal:  J Exp Med       Date:  1988-09-01       Impact factor: 14.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.