Literature DB >> 2901344

Interdependence of CD3-Ti and CD2 activation pathways in human T lymphocytes.

A Alcover1, C Alberini, O Acuto, L K Clayton, C Transy, G C Spagnoli, P Moingeon, P Lopez, E L Reinherz.   

Abstract

Human T lymphocytes can be activated through either the antigen/MHC receptor complex T3-Ti (CD3-Ti) or the T11 (CD2) molecule to proliferate via an IL-2 dependent mechanism. To investigate the relationship of these pathways to one another, we generated and characterized Jurkat mutants which selectively express either surface CD3-Ti or CD2. Here we show that CD3-Ti- mutants fail to be stimulated by either pathway to increase phosphoinositide turnover, mobilize calcium or induce the IL-2 gene. The activation capacity of these mutants via CD2 as well as CD3-Ti can be restored following reconstitution of surface CD3-Ti expression upon appropriate DNA transfer (e.g. Ti beta subunit cDNA into Ti beta- Jurkat variants). Collectively, these results demonstrate that CD3-Ti and CD2 pathways are interdependent and that phosphoinositide turnover is linked to the CD3-Ti complex.

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Year:  1988        PMID： 2901344      PMCID： PMC454469          DOI： 10.1002/j.1460-2075.1988.tb03035.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  38 in total

1.  Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny.

Authors:  H D Royer; D Ramarli; O Acuto; T J Campen; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

2.  The T11 glycoprotein is functionally linked to a calcium channel in precursor and mature T-lineage cells.

Authors:  A Alcover; M J Weiss; J F Daley; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

3.  Activation of human thymocytes via the 50KD T11 sheep erythrocyte binding protein induces the expression of interleukin 2 receptors on both T3+ and T3- populations.

Authors:  D A Fox; R E Hussey; K A Fitzgerald; A Bensussan; J F Daley; S F Schlossman; E L Reinherz
Journal:  J Immunol       Date:  1985-01       Impact factor: 5.422

4.  Regulation of the alternative pathway of T cell activation by anti-T3 monoclonal antibody.

Authors:  D A Fox; S F Schlossman; E L Reinherz
Journal:  J Immunol       Date:  1986-03-15       Impact factor: 5.422

5.  Sequence and expression of transcripts of the human T-cell receptor beta-chain genes.

Authors:  Y Yoshikai; D Anatoniou; S P Clark; Y Yanagi; R Sangster; P Van den Elsen; C Terhorst; T W Mak
Journal:  Nature       Date:  1984 Dec 6-12       Impact factor: 49.962

6.  A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Authors:  G Grynkiewicz; M Poenie; R Y Tsien
Journal:  J Biol Chem       Date:  1985-03-25       Impact factor: 5.157

7.  Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer.

Authors:  P S Ohashi; T W Mak; P Van den Elsen; Y Yanagi; Y Yoshikai; A F Calman; C Terhorst; J D Stobo; A Weiss
Journal:  Nature       Date:  1985 Aug 15-21       Impact factor: 49.962

8.  Interleukin 2 regulates its own receptors.

Authors:  K A Smith; D A Cantrell
Journal:  Proc Natl Acad Sci U S A       Date:  1985-02       Impact factor: 11.205

9.  Activation of cytolytic T lymphocyte and natural killer cell function through the T11 sheep erythrocyte binding protein.

Authors:  R F Siliciano; J C Pratt; R E Schmidt; J Ritz; E L Reinherz
Journal:  Nature       Date:  1985 Oct 3-9       Impact factor: 49.962

10.  Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

Authors:  J B Imboden; J D Stobo
Journal:  J Exp Med       Date:  1985-03-01       Impact factor: 14.307
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  36 in total

1.  Association of Src-like protein tyrosine kinases with the CD2 cell surface molecule in rat T lymphocytes and natural killer cells.

Authors:  G M Bell; J B Bolen; J B Imboden
Journal:  Mol Cell Biol       Date:  1992-12       Impact factor: 4.272

2.  CD3 and CD2 antigen-mediated CD3 gamma-chain phosphorylation in permeabilized human T cells. Regulation by cytosolic phosphatases.

Authors:  D R Alexander; M H Brown; A L Tutt; M J Crumpton; E Shivnan
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

3.  CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells.

Authors:  P Moingeon; J L Lucich; D J McConkey; F Letourneur; B Malissen; J Kochan; H C Chang; H R Rodewald; E L Reinherz
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

4.  Energy of adhesion of human T cells to adsorption layers of monoclonal antibodies measured by a film trapping technique.

Authors:  I B Ivanov; A Hadjiiski; N D Denkov; T D Gurkov; P A Kralchevsky; S Koyasu
Journal:  Biophys J       Date:  1998-07       Impact factor: 4.033

5.  Anti-CD3 antibody-induced expression of both p55 and p75 chains of the high affinity interleukin-2 receptor on human T lymphocytes is inhibited by cyclosporin A.

Authors:  B M Foxwell; J Simon; J J Herrero; D Taylor; G Woerly; D Cantrell; B Ryffel
Journal:  Immunology       Date:  1990-01       Impact factor: 7.397

6.  Major histocompatibility complex independent T cell receptor-antigen interaction: functional analysis using fluorescein derivatives.

Authors:  D J Diamond; P Szalay; D Symer; P Hao; H S Shin; R Z Dintzis; H M Dintzis; E L Reinherz; R F Siliciano
Journal:  J Exp Med       Date:  1991-07-01       Impact factor: 14.307

7.  Regulation of T-cell antigen receptor (TCR) alpha-chain expression by TCR beta-chain transcripts.

Authors:  S Chung; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

8.  Impact of Exogenous Galectin-9 on Human T Cells: CONTRIBUTION OF THE T CELL RECEPTOR COMPLEX TO ANTIGEN-INDEPENDENT ACTIVATION BUT NOT TO APOPTOSIS INDUCTION.

Authors:  Claire Lhuillier; Clément Barjon; Toshiro Niki; Aurore Gelin; Françoise Praz; Olivier Morales; Sylvie Souquere; Mitsuomi Hirashima; Ming Wei; Olivier Dellis; Pierre Busson
Journal:  J Biol Chem       Date:  2015-05-06       Impact factor: 5.157

Review 9.  T cell targeting in cancer therapy.

Authors:  R L Bolhuis; E Sturm; E Braakman
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

10.  The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.

Authors:  S J Anderson; M Lenburg; N R Landau; J V Garcia
Journal:  J Virol       Date:  1994-05       Impact factor: 5.103
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