Literature DB >> 29547607

Heparin Versus Normal Saline: Flushing Effectiveness in Managing Central Venous Catheters in Patients Undergoing Blood and Marrow Transplantation

John Klein1, Amelia Jepsen2, Amy Patterson1, Richard R Reich1, Tina M Mason1.   

Abstract

BACKGROUND: Patients undergoing blood and marrow transplantation (BMT) use a central venous catheter (CVC); heparin is often employed to maintain patency but may increase the risk of complications. Research has not provided conclusive differences in efficacy and safety regarding heparin flushing versus normal saline flushing in CVC maintenance. Minimal research is specific to this patient population.
OBJECTIVES: This study aimed to determine if differences exist in CVC patency, tissue plasminogen activator usage, and the incidence of central line-associated bloodstream infections when flushing with normal saline only versus heparin and normal saline among patients undergoing BMT.
METHODS: A convenience sample of 30 patients undergoing allogeneic or autologous transplantation with a new non-port/non-peripherally inserted CVC were evaluated.
FINDINGS: Elimination of routine heparin use could positively affect outcomes in this patient population.

Entities:  

Keywords:  blood and marrow transplantation; central line; central venous catheter; saline flush

Mesh:

Substances:

Year:  2018        PMID: 29547607     DOI: 10.1188/18.CJON.199-202

Source DB:  PubMed          Journal:  Clin J Oncol Nurs        ISSN: 1092-1095            Impact factor:   1.027


  9 in total

1.  Normal saline (0.9% sodium chloride) versus heparin intermittent flushing for the prevention of occlusion in long-term central venous catheters in infants and children.

Authors:  Natalie K Bradford; Rachel M Edwards; Raymond J Chan
Journal:  Cochrane Database Syst Rev       Date:  2020-04-30

Review 2.  Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.

Authors:  Eduardo López-Briz; Vicente Ruiz Garcia; Juan B Cabello; Sylvia Bort-Martí; Rafael Carbonell Sanchis
Journal:  Cochrane Database Syst Rev       Date:  2022-07-18

3. 

Authors:  Terri Jabaley; Niya Xiong; Susanne Conley; Teresa Mazeika; Danielle Johnson; Brenda A Biggins; Nancy Hilton; Fangxin Hong
Journal:  Can Oncol Nurs J       Date:  2022-04-01

4.  Transitioning from heparin to saline locks for central venous access devices in oncology: An evidence-based practice approach.

Authors:  Terri Jabaley; Niya Xiong; Susanne Conley; Teresa Mazeika; Danielle Johnson; Brenda A Biggins; Nancy Hilton; Fangxin Hong
Journal:  Can Oncol Nurs J       Date:  2022-04-01

Review 5.  Dosage of heparin for patency of the totally implanted central venous catheter in cancer patients.

Authors:  Francisca Jane Gomes de Oliveira; Andrea Bezerra Rodrigues; Islane Costa Ramos; Joselany Áfio Caetano
Journal:  Rev Lat Am Enfermagem       Date:  2020-06-19

6.  Comparison of heparinized saline and 0.9% sodium chloride for maintaining central venous catheter patency in healthy dogs.

Authors:  Julieann Vose; Adesola Odunayo; Joshua M Price; Maggie Daves; Julie C Schildt; M Katherine Tolbert
Journal:  PeerJ       Date:  2019-05-31       Impact factor: 2.984

Review 7.  Heparin flush vs. normal saline flush to maintain the patency of central venous catheter among adult patients: A systematic review and meta-analysis.

Authors:  Suresh K Sharma; Shiv K Mudgal; Rakhi Gaur; Rakesh Sharma; Maneesh Sharma; Kalpana Thakur
Journal:  J Family Med Prim Care       Date:  2019-09-30

8.  Comparing the Effects of Pulsatile and Continuous Flushing on Time and Type of Peripheral Intravenous Catheters Patency: A Randomized Clinical Trial.

Authors:  Seyed Javad Hosseini; Fereshteh Eidy; Majid Kianmehr; Ali Asghar Firouzian; Fatemeh Hajiabadi; Mahmoud Marhamati; Mahbobeh Firooz
Journal:  J Caring Sci       Date:  2021-05-24

Review 9.  Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.

Authors:  Eduardo López-Briz; Vicente Ruiz Garcia; Juan B Cabello; Sylvia Bort-Martí; Rafael Carbonell Sanchis; Amanda Burls
Journal:  Cochrane Database Syst Rev       Date:  2018-07-30
  9 in total

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