Literature DB >> 2954714

Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats.

F T Garzon, M R Berger, B K Keppler, D Schmähl.   

Abstract

The activity of the newly synthesized ruthenium derivative imidazolium-bis(imidazole)tetrachlororuthenate (III) [ImH(RuIm2Cl4)] was compared with that of 5'-deoxy-5-fluorouridine (5'dFUR) in autochthonous acetoxy-methyl-methylnitrosamine (AMMN)-induced colorectal cancer in SD rats. Following coloscopic diagnosis of colorectal tumors treatment was administered twice weekly for a 10-week period. ImH(RuIm2Cl4) exhibited considerable antitumoral efficacy compared with 5'dFUR (20 T/C % and 60 T/C %, respectively) against the growth of AMMN-induced colorectal adenocarcinoma in SD rats. The mortality rates with ImH(RuIm2Cl4) were dose-related, but its efficacy did not vary in all doses administered.

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Year:  1987        PMID： 2954714     DOI： 10.1007/bf00261487

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  13 in total

1.  Cancer statistics. 1986.

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Journal:  CA Cancer J Clin       Date:  1986 Jan-Feb       Impact factor: 508.702

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Authors:  H J Keller; B Keppler; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

3.  Evaluation of endoscopic examination of colon tumors in rats.

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4.  Phase II study of doxifluridine in advanced colorectal adenocarcinoma.

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Journal:  J Clin Oncol       Date:  1983-12       Impact factor: 44.544

5.  Adjuvant therapy of colon cancer--results of a prospectively randomized trial.

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Journal:  N Engl J Med       Date:  1984-03-22       Impact factor: 91.245

6.  Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.

Authors:  H Ishitsuka; M Miwa; K Takemoto; K Fukuoka; A Itoga; H B Maruyama
Journal:  Gan       Date:  1980-02

7.  Chemotherapeutic studies on N-nitrosoacetoxymethyl-methylamine-and 1,2-dimethylhydrazine-induced colonic tumors in rats: monotherapy with 5-fluorouracil, ftorafur, CGP 6809, and CGP 15'720A.

Authors:  I Wagner; M Habs; D Schmähl; H Amberger; U Bachmann
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

8.  Endoscopic diagnosis of chemically induced autochthonous colonic tumors in rats.

Authors:  R Merz; I Wagner; M Habs; D Schmähl; H Amberger; U Bachmann
Journal:  Hepatogastroenterology       Date:  1981-02

9.  Chemically induced autochthonous tumor models in experimental chemotherapy.

Authors:  W J Zeller; M R Berger
Journal:  Behring Inst Mitt       Date:  1984-05

10.  Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato) titanium(IV) compounds against Walker 256 carcinosarcoma. A new class of antineoplastic agents.

Authors:  H J Keller; B Keppler; D Schmähl
Journal:  Arzneimittelforschung       Date:  1982
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  10 in total

1.  Na[trans-RuCl4(DMSO)Im], a metal complex of ruthenium with antimetastatic properties.

Authors:  G Sava; S Pacor; G Mestroni; E Alessio
Journal:  Clin Exp Metastasis       Date:  1992-07       Impact factor: 5.150

2.  Arene-Ru(II)-chloroquine complexes interact with DNA, induce apoptosis on human lymphoid cell lines and display low toxicity to normal mammalian cells.

Authors:  Alberto Martínez; Chandima S K Rajapakse; Roberto A Sánchez-Delgado; Armando Varela-Ramirez; Carolina Lema; Renato J Aguilera
Journal:  J Inorg Biochem       Date:  2010-05-15       Impact factor: 4.155

3.  Activity of two platinum-linked phosphonic acids against autochthonous rat colorectal cancer as well as in two human colon-cancer cell lines.

Authors:  A Galeano; M R Berger; B K Keppler
Journal:  Cancer Chemother Pharmacol       Date:  1992       Impact factor: 3.333

Review 4.  Bioactivity and Development of Small Non-Platinum Metal-Based Chemotherapeutics.

Authors:  Maria Grazia Ferraro; Marialuisa Piccolo; Gabriella Misso; Rita Santamaria; Carlo Irace
Journal:  Pharmaceutics       Date:  2022-04-28       Impact factor: 6.525

5.  Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats.

Authors:  M H Seelig; M R Berger; B K Keppler
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

Review 6.  Unusual DNA binding modes for metal anticancer complexes.

Authors:  Ana M Pizarro; Peter J Sadler
Journal:  Biochimie       Date:  2009-04-01       Impact factor: 4.079

Review 7.  Complexes of metals other than platinum as antitumour agents.

Authors:  P Köpf-Maier
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

8.  Analysis of the cytotoxic effects of ruthenium-ketoconazole and ruthenium-clotrimazole complexes on cancer cells.

Authors:  Elisa Robles-Escajeda; Alberto Martínez; Armando Varela-Ramirez; Roberto A Sánchez-Delgado; Renato J Aguilera
Journal:  Cell Biol Toxicol       Date:  2013-11-24       Impact factor: 6.691

9.  In vitro evaluation of platinum, titanium and ruthenium metal complexes in cisplatin-sensitive and -resistant rat ovarian tumors.

Authors:  S Frühauf; W J Zeller
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

10.  The palladium-based complexes bearing 1,3-dibenzylbenzimidazolium with morpholine, triphenylphosphine, and pyridine derivate ligands: synthesis, characterization, structure and enzyme inhibitions.

Authors:  Aydın Aktaş; Gül Yakalı; Yeliz Demir; İlhami Gülçin; Muhittin Aygün; Yetkin Gök
Journal:  Heliyon       Date:  2022-09-16
  10 in total

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