Literature DB >> 29547009

Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling.

Fedir N Kiskin1, C-Hong Chang1, Christopher J Z Huang1, Baraa Kwieder1,2, Christine Cheung3,4, Benjamin J Dunmore1, Felipe Serrano1, Sanjay Sinha1,2,4,5, Nicholas W Morrell1,2,5, Amer A Rana1,2,5.   

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Year:  2018        PMID： 29547009      PMCID： PMC6058985          DOI： 10.1164/rccm.201801-0049LE

Source DB:  PubMed          Journal:  Am J Respir Crit Care Med        ISSN： 1073-449X            Impact factor:   21.405


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  9 in total

1.  Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers.

Authors:  Mingxia Gu; Ning-Yi Shao; Silin Sa; Dan Li; Vittavat Termglinchan; Mohamed Ameen; Ioannis Karakikes; Gustavo Sosa; Fabian Grubert; Jaecheol Lee; Aiqin Cao; Shalina Taylor; Yu Ma; Zhixin Zhao; James Chappell; Rizwan Hamid; Eric D Austin; Joseph D Gold; Joseph C Wu; Michael P Snyder; Marlene Rabinovitch
Journal:  Cell Stem Cell       Date:  2016-12-22       Impact factor: 24.633

Review 2.  Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs.

Authors:  Soni Savai Pullamsetti; Rajkumar Savai; Werner Seeger; Elena A Goncharova
Journal:  Am J Respir Crit Care Med       Date:  2017-02-15       Impact factor: 21.405

Review 3.  Regulation of endothelial cell differentiation and specification.

Authors:  Kathrina L Marcelo; Lauren C Goldie; Karen K Hirschi
Journal:  Circ Res       Date:  2013-04-26       Impact factor: 17.367

4.  Induced Pluripotent Stem Cell Model of Pulmonary Arterial Hypertension Reveals Novel Gene Expression and Patient Specificity.

Authors:  Silin Sa; Mingxia Gu; James Chappell; Ning-Yi Shao; Mohamed Ameen; Kathryn A T Elliott; Dan Li; Fabian Grubert; Caiyun G Li; Shalina Taylor; Aiqin Cao; Yu Ma; Ryan Fong; Long Nguyen; Joseph C Wu; Michael P Snyder; Marlene Rabinovitch
Journal:  Am J Respir Crit Care Med       Date:  2017-04-01       Impact factor: 21.405

5.  Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.

Authors:  Xudong Yang; Lu Long; Mark Southwood; Nung Rudarakanchana; Paul D Upton; Trina K Jeffery; Carl Atkinson; Hailan Chen; Richard C Trembath; Nicholas W Morrell
Journal:  Circ Res       Date:  2005-04-21       Impact factor: 17.367

6.  Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.

Authors:  James D West; Eric D Austin; Christa Gaskill; Shennea Marriott; Rubin Baskir; Ganna Bilousova; Jyh-Chang Jean; Anna R Hemnes; Swapna Menon; Nathaniel C Bloodworth; Joshua P Fessel; Johnathan A Kropski; David Irwin; Lorraine B Ware; Lisa Wheeler; Charles C Hong; Barbara Meyrick; James E Loyd; Aaron B Bowman; Kevin C Ess; Dwight J Klemm; Pampee P Young; W David Merryman; Darrell Kotton; Susan M Majka
Journal:  Am J Physiol Cell Physiol       Date:  2014-05-28       Impact factor: 4.249

7.  Bone morphogenetic protein receptor type II deficiency and increased inflammatory cytokine production. A gateway to pulmonary arterial hypertension.

Authors:  Elaine Soon; Alexi Crosby; Mark Southwood; Peiran Yang; Tamara Tajsic; Mark Toshner; Sarah Appleby; Catherine M Shanahan; Kenneth D Bloch; Joanna Pepke-Zaba; Paul Upton; Nicholas W Morrell
Journal:  Am J Respir Crit Care Med       Date:  2015-10-01       Impact factor: 30.528

8.  Generation of human vascular smooth muscle subtypes provides insight into embryological origin-dependent disease susceptibility.

Authors:  Christine Cheung; Andreia S Bernardo; Matthew W B Trotter; Roger A Pedersen; Sanjay Sinha
Journal:  Nat Biotechnol       Date:  2012-01-15       Impact factor: 54.908

9.  Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension.

Authors:  Lu Long; Mark L Ormiston; Xudong Yang; Mark Southwood; Stefan Gräf; Rajiv D Machado; Matthias Mueller; Bernd Kinzel; Lai Ming Yung; Janine M Wilkinson; Stephen D Moore; Kylie M Drake; Micheala A Aldred; Paul B Yu; Paul D Upton; Nicholas W Morrell
Journal:  Nat Med       Date:  2015-06-15       Impact factor: 53.440
  9 in total
  9 in total

1.  Precision Modeling of Pulmonary Hypertension Pathology with Induced Pluripotent Stem Cell-derived Cells.

Authors:  James D West; Erica J Carrier
Journal:  Am J Respir Crit Care Med       Date:  2018-07-15       Impact factor: 21.405

2.  The P2-receptor-mediated Ca2+ signalosome of the human pulmonary endothelium - implications for pulmonary arterial hypertension.

Authors:  Jan K Hennigs; Nicole Lüneburg; Annett Stage; Melanie Schmitz; Jakob Körbelin; Lars Harbaum; Christiane Matuszcak; Julia Mienert; Carsten Bokemeyer; Rainer H Böger; Rainer Kiefmann; Hans Klose
Journal:  Purinergic Signal       Date:  2019-08-08       Impact factor: 3.765

Review 3.  Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains.

Authors:  Miranda K Culley; Stephen Y Chan
Journal:  J Clin Invest       Date:  2018-08-06       Impact factor: 14.808

Review 4.  Genetics and genomics of pulmonary arterial hypertension.

Authors:  Nicholas W Morrell; Micheala A Aldred; Wendy K Chung; C Gregory Elliott; William C Nichols; Florent Soubrier; Richard C Trembath; James E Loyd
Journal:  Eur Respir J       Date:  2019-01-24       Impact factor: 16.671

5.  An iPSC-Derived Myeloid Lineage Model of Herpes Virus Latency and Reactivation.

Authors:  Emma Poole; Christopher J Z Huang; Jessica Forbester; Miri Shnayder; Aharon Nachshon; Baraa Kweider; Anna Basaj; Daniel Smith; Sarah Elizabeth Jackson; Bin Liu; Joy Shih; Fedir N Kiskin; K Roche; E Murphy; Mark R Wills; Nicholas W Morrell; Gordon Dougan; Noam Stern-Ginossar; Amer A Rana; John Sinclair
Journal:  Front Microbiol       Date:  2019-10-09       Impact factor: 5.640

6.  Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension.

Authors:  Maria Catalina Gomez-Puerto; Iris van Zuijen; Christopher Jz Huang; Robert Szulcek; Xiaoke Pan; Maarten Ah van Dinther; Kondababu Kurakula; Catharina C Wiesmeijer; Marie-Jose Goumans; Harm-Jan Bogaard; Nicholas W Morrell; Amer Ahmed Rana; Peter Ten Dijke
Journal:  J Pathol       Date:  2019-08-27       Impact factor: 7.996

Review 7.  Repurposing of medications for pulmonary arterial hypertension.

Authors:  Mark Toshner; Edda Spiekerkoetter; Harm Bogaard; Georg Hansmann; Sylvia Nikkho; Kurt W Prins
Journal:  Pulm Circ       Date:  2020-11-18       Impact factor: 3.017

8.  CRISPR-mediated Bmpr2 point mutation exacerbates late pulmonary vasculopathy and reduces survival in rats with experimental pulmonary hypertension.

Authors:  Jane Chanda Kabwe; Hirofumi Sawada; Yoshihide Mitani; Hironori Oshita; Naoki Tsuboya; Erquan Zhang; Junko Maruyama; Yoshiki Miyasaka; Hideyoshi Ko; Kazunobu Oya; Hiromasa Ito; Noriko Yodoya; Shoichiro Otsuki; Hiroyuki Ohashi; Ryuji Okamoto; Kaoru Dohi; Yuhei Nishimura; Tomoji Mashimo; Masahiro Hirayama; Kazuo Maruyama
Journal:  Respir Res       Date:  2022-04-08

9.  A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells.

Authors:  Emma Poole; Maria Cristina Carlan da Silva; Chris Huang; Marianne Perera; Sarah Jackson; Ian J Groves; Mark Wills; Amer Rana; John Sinclair
Journal:  mBio       Date:  2021-06-01       Impact factor: 7.867
  9 in total

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