Literature DB >> 29545426

Coinfection of leprosy and tuberculosis.

Seema Shetty1, Shashikiran Umakanth1, Bhawani Manandhar2, Pankaj Bahadur Nepali3.   

Abstract

Leprosy and tuberculosis (TB) are endemic to India, however, their coinfection is not frequently encountered in clinical practice. Here, we report a 32-year-old female patient who presented with a history of high-grade intermittent fever, cough and painless skin lesions since a month, along with bilateral claw hand (on examination). The haematological profile was suggestive of anaemia of chronic disease, chest radiograph showed consolidation, sputum smears were positive for Mycobacterium tuberculosis, and skin slit smear confirmed leprosy. The patient was prescribed WHO recommended multidrug therapy for multibacillary leprosy with three drugs. Additionally, prednisolone was added to her regimen for 2 weeks to treat the type 2 lepra reaction. For treatment of TB, she was placed on the standard 6-month short course chemotherapy. She was lost to follow-up, and attempts were made to contact her. Later, it came to our notice that she had discontinued medications and passed away 3 months after diagnosis. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  TB and other respiratory infections; dermatology; infectious diseases

Mesh:

Year:  2018        PMID: 29545426      PMCID: PMC5878375          DOI: 10.1136/bcr-2017-222352

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  17 in total

1.  Randomised controlled trial of single BCG, repeated BCG, or combined BCG and killed Mycobacterium leprae vaccine for prevention of leprosy and tuberculosis in Malawi. Karonga Prevention Trial Group.

Authors: 
Journal:  Lancet       Date:  1996-07-06       Impact factor: 79.321

2.  The role of BCG in prevention of leprosy: a meta-analysis.

Authors:  Maninder Singh Setia; Craig Steinmaus; Christine S Ho; George W Rutherford
Journal:  Lancet Infect Dis       Date:  2006-03       Impact factor: 25.071

3.  A study of leprosy reactions in a tertiary hospital in Delhi.

Authors:  Neelu Sharma; Ravindra V Koranne; Vibhu Mendiratta; Ravi Chandra Sharma
Journal:  J Dermatol       Date:  2004-11       Impact factor: 4.005

4.  Global leprosy update, 2015: time for action, accountability and inclusion.

Authors: 
Journal:  Wkly Epidemiol Rec       Date:  2015-09-02

Review 5.  Clinical aspects of leprosy.

Authors:  Carolina Talhari; Sinésio Talhari; Gerson Oliveira Penna
Journal:  Clin Dermatol       Date:  2015 Jan-Feb       Impact factor: 3.541

6.  Leprosy and tuberculosis: the epidemiological consequences of cross-immunity.

Authors:  T Lietman; T Porco; S Blower
Journal:  Am J Public Health       Date:  1997-12       Impact factor: 9.308

Review 7.  Leprosy.

Authors:  Warwick J Britton; Diana N J Lockwood
Journal:  Lancet       Date:  2004-04-10       Impact factor: 79.321

Review 8.  Treatment of leprosy/Hansen's disease in the early 21st century.

Authors:  Sophie M Worobec
Journal:  Dermatol Ther       Date:  2009 Nov-Dec       Impact factor: 2.851

Review 9.  Leprosy and tuberculosis co-infection: clinical and immunological report of two cases and review of the literature.

Authors:  Maria Ângela B Trindade; Denise Miyamoto; Gil Benard; Neusa Y Sakai-Valente; Dewton de M Vasconcelos; Bernard Naafs
Journal:  Am J Trop Med Hyg       Date:  2012-12-03       Impact factor: 2.345

10.  Rapid differentiation of Mycobacterium tuberculosis and Mycobacterium leprae from sputum by polymerase chain reaction.

Authors:  Bishwa Raj Sapkota; Chaman Ranjit; Murdo Macdonald
Journal:  Nepal Med Coll J       Date:  2007-03
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  1 in total

1.  Leprosy cases with respiratory infection - Rule out tuberculosis simultaneously with dapsone syndrome.

Authors:  Pugazhenthan Thangaraju; Sajitha Venkatesan
Journal:  Indian J Pharmacol       Date:  2018 Jul-Aug       Impact factor: 1.200

  1 in total

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