Literature DB >> 16500597

The role of BCG in prevention of leprosy: a meta-analysis.

Maninder Singh Setia1, Craig Steinmaus, Christine S Ho, George W Rutherford.   

Abstract

The present meta-analysis investigates the role of BCG-a widely used yet controversial vaccine-in the prevention of leprosy. The electronic databases Medline, Embase, the Cochrane Library, and LILACS were searched to identify studies assessing the protective effect of BCG against leprosy. We included seven experimental studies and 19 observational studies. The experimental studies demonstrated an overall protective effect of 26% (95% CI 14-37%). At 61% (95% CI 51-70%), the observational studies overestimated the protective effect. The age at vaccination did not predict the protective effect of BCG. An additional dose of BCG was more protective in the prevention of leprosy compared with a single dose. An additional dose of BCG may be warranted for contacts of leprosy patients in areas where leprosy continues to be a public-health problem.

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Year:  2006        PMID： 16500597     DOI： 10.1016/S1473-3099(06)70412-1

Source DB:  PubMed          Journal:  Lancet Infect Dis        ISSN： 1473-3099            Impact factor:   25.071


  52 in total

1.  Chemoprophylaxis in the prevention of leprosy.

Authors:  W Cairns S Smith
Journal:  BMJ       Date:  2008-04-05

2.  Protection against Mycobacterium leprae infection by the ID83/GLA-SE and ID93/GLA-SE vaccines developed for tuberculosis.

Authors:  Malcolm S Duthie; Rhea N Coler; John D Laurance; Lucas H Sampaio; Regiane M Oliveira; Ana Lucia M Sousa; Mariane M A Stefani; Yumi Maeda; Masanori Matsuoka; Masahiko Makino; Steven G Reed
Journal:  Infect Immun       Date:  2014-07-14       Impact factor: 3.441

Review 3.  Mycobacterium leprae-host-cell interactions and genetic determinants in leprosy: an overview.

Authors:  Roberta Olmo Pinheiro; Jorgenilce de Souza Salles; Euzenir Nunes Sarno; Elizabeth Pereira Sampaio
Journal:  Future Microbiol       Date:  2011-02       Impact factor: 3.165

Review 4.  Tuberculosis susceptibility and protection in children.

Authors:  Robindra Basu Roy; Elizabeth Whittaker; James A Seddon; Beate Kampmann
Journal:  Lancet Infect Dis       Date:  2018-10-12       Impact factor: 25.071

Review 5.  Prevention and control of neglected tropical diseases: overview of randomized trials, systematic reviews and meta-analyses.

Authors:  Shanthi Kappagoda; John P A Ioannidis
Journal:  Bull World Health Organ       Date:  2014-03-13       Impact factor: 9.408

6.  Coinfection of leprosy and tuberculosis.

Authors:  Seema Shetty; Shashikiran Umakanth; Bhawani Manandhar; Pankaj Bahadur Nepali
Journal:  BMJ Case Rep       Date:  2018-03-15

7.  Risk and protective factors for leprosy development determined by epidemiological surveillance of household contacts.

Authors:  Isabela M B Goulart; Dulcinéa O Bernardes Souza; Carolina R Marques; Vânia L Pimenta; Maria A Gonçalves; Luiz R Goulart
Journal:  Clin Vaccine Immunol       Date:  2007-11-07

8.  Different mechanisms for heterogeneity in leprosy susceptibility can explain disease clustering within households.

Authors:  Egil Fischer; Sake De Vlas; Abraham Meima; Dik Habbema; Jan Richardus
Journal:  PLoS One       Date:  2010-11-19       Impact factor: 3.240

9.  Vaccination with the ML0276 antigen reduces local inflammation but not bacterial burden during experimental Mycobacterium leprae infection.

Authors:  Vanitha S Raman; Joanne O'Donnell; H Remy Bailor; Wakako Goto; Ramanuj Lahiri; Thomas P Gillis; Steven G Reed; Malcolm S Duthie
Journal:  Infect Immun       Date:  2009-09-28       Impact factor: 3.441

Review 10.  Leprosy.

Authors:  Diana Nj Lockwood
Journal:  BMJ Clin Evid       Date:  2007-04-01
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