Literature DB >> 29543654

IL-7 treatment supports CD8+ mucosa-associated invariant T-cell restoration in HIV-1-infected patients on antiretroviral therapy.

Ornella Sortino1,2,3, Elizabeth Richards2,3, Joana Dias4, Edwin Leeansyah4,5, Johan K Sandberg4,3, Irini Sereti2,3.   

Abstract

: Chronic HIV-1 infection is associated with lower frequencies and functional impairment of mucosa-associated invariant T (MAIT) cells. We evaluated IL-7 treatment to restore MAIT cells in peripheral blood of chronically HIV-1-infected individuals on antiretroviral therapy. IL-7 led to increased relative and absolute levels of MAIT cells, and this expansion occurred primarily in the CD8 subset. These results suggest that IL-7 may represent a therapeutic intervention for the restoration of MAIT cells in chronic HIV-1 infection.

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Year:  2018        PMID： 29543654      PMCID： PMC6056340          DOI： 10.1097/QAD.0000000000001760

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.632


  9 in total

1.  Activation, exhaustion, and persistent decline of the antimicrobial MR1-restricted MAIT-cell population in chronic HIV-1 infection.

Authors:  Edwin Leeansyah; Anupama Ganesh; Máire F Quigley; Anders Sönnerborg; Jan Andersson; Peter W Hunt; Ma Somsouk; Steven G Deeks; Jeffrey N Martin; Markus Moll; Barbara L Shacklett; Johan K Sandberg
Journal:  Blood       Date:  2012-12-13       Impact factor: 22.113

2.  MR1 presents microbial vitamin B metabolites to MAIT cells.

Authors:  Lars Kjer-Nielsen; Onisha Patel; Alexandra J Corbett; Jérôme Le Nours; Bronwyn Meehan; Ligong Liu; Mugdha Bhati; Zhenjun Chen; Lyudmila Kostenko; Rangsima Reantragoon; Nicholas A Williamson; Anthony W Purcell; Nadine L Dudek; Malcolm J McConville; Richard A J O'Hair; George N Khairallah; Dale I Godfrey; David P Fairlie; Jamie Rossjohn; James McCluskey
Journal:  Nature       Date:  2012-10-10       Impact factor: 49.962

3.  Antimicrobial activity of mucosal-associated invariant T cells.

Authors:  Lionel Le Bourhis; Emmanuel Martin; Isabelle Péguillet; Amélie Guihot; Nathalie Froux; Maxime Coré; Eva Lévy; Mathilde Dusseaux; Vanina Meyssonnier; Virginie Premel; Charlotte Ngo; Béatrice Riteau; Livine Duban; Delphine Robert; Shouxiong Huang; Martin Rottman; Claire Soudais; Olivier Lantz
Journal:  Nat Immunol       Date:  2010-06-27       Impact factor: 25.606

Review 4.  The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostasis and the challenges facing its utilization as a novel therapy.

Authors:  Sarah C Sasson; John J Zaunders; Anthony D Kelleher
Journal:  Curr Drug Targets       Date:  2006-12       Impact factor: 3.465

5.  Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment.

Authors:  Yves Levy; Christine Lacabaratz; Laurence Weiss; Jean-Paul Viard; Cecile Goujard; Jean-Daniel Lelièvre; François Boué; Jean-Michel Molina; Christine Rouzioux; Véronique Avettand-Fénoêl; Thérèse Croughs; Stéphanie Beq; Rodolphe Thiébaut; Geneviève Chêne; Michel Morre; Jean-François Delfraissy
Journal:  J Clin Invest       Date:  2009-03-16       Impact factor: 14.808

6.  IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection.

Authors:  Irini Sereti; Richard M Dunham; John Spritzler; Evgenia Aga; Michael A Proschan; Kathy Medvik; Catherine A Battaglia; Alan L Landay; Savita Pahwa; Margaret A Fischl; David M Asmuth; Allan R Tenorio; John D Altman; Lawrence Fox; Susan Moir; Angela Malaspina; Michel Morre; Renaud Buffet; Guido Silvestri; Michael M Lederman
Journal:  Blood       Date:  2009-04-20       Impact factor: 22.113

7.  Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study.

Authors:  Y Lévy; I Sereti; G Tambussi; J P Routy; J D Lelièvre; J F Delfraissy; J M Molina; M Fischl; C Goujard; B Rodriguez; C Rouzioux; V Avettand-Fenoël; T Croughs; S Beq; M Morre; J F Poulin; R P Sekaly; R Thiebaut; M M Lederman
Journal:  Clin Infect Dis       Date:  2012-05-01       Impact factor: 9.079

8.  Arming of MAIT Cell Cytolytic Antimicrobial Activity Is Induced by IL-7 and Defective in HIV-1 Infection.

Authors:  Edwin Leeansyah; Jenny Svärd; Joana Dias; Marcus Buggert; Jessica Nyström; Máire F Quigley; Markus Moll; Anders Sönnerborg; Piotr Nowak; Johan K Sandberg
Journal:  PLoS Pathog       Date:  2015-08-21       Impact factor: 6.823

9.  Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration.

Authors:  Irini Sereti; Jacob D Estes; William L Thompson; David R Morcock; Margaret A Fischl; Thérèse Croughs; Stéphanie Beq; Sylvie Lafaye de Micheaux; Michael D Yao; Alexander Ober; Eleanor M P Wilson; Ven Natarajan; Hiromi Imamichi; Mohamed R Boulassel; Michael M Lederman; Jean-Pierre Routy
Journal:  PLoS Pathog       Date:  2014-01-30       Impact factor: 6.823
  9 in total
  16 in total

1.  Opsonization-Enhanced Antigen Presentation by MR1 Activates Rapid Polyfunctional MAIT Cell Responses Acting as an Effector Arm of Humoral Antibacterial Immunity.

Authors:  Caroline Boulouis; Jean-Baptiste Gorin; Joana Dias; Peter Bergman; Edwin Leeansyah; Johan K Sandberg
Journal:  J Immunol       Date:  2020-05-20       Impact factor: 5.422

2.  Preserved Mucosal-Associated Invariant T-Cell Numbers and Function in Idiopathic CD4 Lymphocytopenia.

Authors:  Ornella Sortino; Joana Dias; Megan Anderson; Elizabeth Laidlaw; Edwin Leeansyah; Andrea Lisco; Virginia Sheikh; Johan K Sandberg; Irini Sereti
Journal:  J Infect Dis       Date:  2021-08-16       Impact factor: 5.226

Review 3.  Mucosal-associated invariant T cells and disease.

Authors:  Amine Toubal; Isabelle Nel; Sophie Lotersztajn; Agnès Lehuen
Journal:  Nat Rev Immunol       Date:  2019-10       Impact factor: 53.106

Review 4.  Flip the coin: IL-7 and IL-7R in health and disease.

Authors:  João T Barata; Scott K Durum; Benedict Seddon
Journal:  Nat Immunol       Date:  2019-11-19       Impact factor: 25.606

5.  Exercise training partially rescues impaired mucosal associated invariant t-cell mobilization in breast cancer survivors compared to healthy older women.

Authors:  Erik D Hanson; Lauren C Bates; Elizabeth P Harrell; David B Bartlett; Jordan T Lee; Chad W Wagoner; Mohamdod S Alzer; Dean J Amatuli; Brian C Jensen; Allison M Deal; Hyman B Muss; Kirsten A Nyrop; Claudio L Battaglini
Journal:  Exp Gerontol       Date:  2021-06-16       Impact factor: 4.253

6.  Latent Mycobacterium tuberculosis Infection Is Associated With a Higher Frequency of Mucosal-Associated Invariant T and Invariant Natural Killer T Cells.

Authors:  Dominic Paquin-Proulx; Priscilla R Costa; Cassia G Terrassani Silveira; Mariana P Marmorato; Natalia B Cerqueira; Matthew S Sutton; Shelby L O'Connor; Karina I Carvalho; Douglas F Nixon; Esper G Kallas
Journal:  Front Immunol       Date:  2018-06-19       Impact factor: 7.561

Review 7.  CD8+ T-Cell Response to HIV Infection in the Era of Antiretroviral Therapy.

Authors:  Federico Perdomo-Celis; Natalia A Taborda; Maria T Rugeles
Journal:  Front Immunol       Date:  2019-08-09       Impact factor: 7.561

8.  Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection.

Authors:  X Tang; S Zhang; Q Peng; L Ling; H Shi; Y Liu; L Cheng; L Xu; L Cheng; L A Chakrabarti; Z Chen; H Wang; Z Zhang
Journal:  Sci Adv       Date:  2020-02-19       Impact factor: 14.136

Review 9.  Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection.

Authors:  Ryan V Moriarty; Amy L Ellis; Shelby L O'Connor
Journal:  Viruses       Date:  2021-05-08       Impact factor: 5.818

10.  In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection.

Authors:  Satanay Hubrack; Maryam Ali Al-Nesf; Nourhen Agrebi; Christophe Raynaud; Mohammed Abu Khattab; Merlin Thomas; Tayseer Ibrahim; Salma Taha; Said Dermime; Maysaloun Merhi; Michal Kulinski; Martin Steinhoff; Patrick Tang; Bernice Lo
Journal:  Sci Rep       Date:  2021-07-08       Impact factor: 4.379
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