Literature DB >> 31745336

Flip the coin: IL-7 and IL-7R in health and disease.

João T Barata1, Scott K Durum2, Benedict Seddon3.   

Abstract

The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and generation and maintenance of memory T cells. They are also required for innate lymphoid cell (ILC) development and maintenance, and consequently for generation of lymphoid structures and barrier defense. Here we discuss the central role of IL-7 and IL-7R in the lymphoid system and highlight the impact of their deregulation, placing a particular emphasis on their 'dark side' as promoters of cancer development. We also explore therapeutic implications and opportunities associated with either positive or negative modulation of the IL-7-IL-7R signaling axis.

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Year:  2019        PMID： 31745336     DOI： 10.1038/s41590-019-0479-x

Source DB:  PubMed          Journal:  Nat Immunol        ISSN： 1529-2908            Impact factor:   25.606


  126 in total

1.  The long-term survival potential of mature T lymphocytes is programmed during development in the thymus.

Authors:  Charles Sinclair; Manoj Saini; Ina Schim van der Loeff; Shimon Sakaguchi; Benedict Seddon
Journal:  Sci Signal       Date:  2011-11-15       Impact factor: 8.192

2.  Hepatic interleukin-7 expression regulates T cell responses.

Authors:  Yukihisa Sawa; Yasunobu Arima; Hideki Ogura; Chika Kitabayashi; Jing-Jing Jiang; Toru Fukushima; Daisuke Kamimura; Toshio Hirano; Masaaki Murakami
Journal:  Immunity       Date:  2009-03-12       Impact factor: 31.745

3.  Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.

Authors:  Alexander Link; Tobias K Vogt; Stéphanie Favre; Mirjam R Britschgi; Hans Acha-Orbea; Boris Hinz; Jason G Cyster; Sanjiv A Luther
Journal:  Nat Immunol       Date:  2007-09-23       Impact factor: 25.606

4.  Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage.

Authors:  Maria Iolyeva; David Aebischer; Steven T Proulx; Ann-Helen Willrodt; Tatiana Ecoiffier; Simone Häner; Grégory Bouchaud; Carsten Krieg; Lucas Onder; Burkhard Ludewig; Laura Santambrogio; Onur Boyman; Lu Chen; Daniela Finke; Cornelia Halin
Journal:  Blood       Date:  2013-08-20       Impact factor: 22.113

5.  Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells.

Authors:  M Moors; N K Vudattu; J Abel; U Krämer; L Rane; N Ulfig; S Ceccatelli; V Seyfert-Margolies; E Fritsche; M J Maeurer
Journal:  Genes Immun       Date:  2009-10-22       Impact factor: 2.676

6.  Analysis of cytokine gene expression in subpopulations of freshly isolated thymocytes and thymic stromal cells using semiquantitative polymerase chain reaction.

Authors:  N C Moore; G Anderson; C A Smith; J J Owen; E J Jenkinson
Journal:  Eur J Immunol       Date:  1993-04       Impact factor: 5.532

7.  Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation.

Authors:  Kenta Shinoda; Kiyoshi Hirahara; Tomohisa Iinuma; Tomomi Ichikawa; Akane S Suzuki; Kaoru Sugaya; Damon J Tumes; Heizaburo Yamamoto; Takahiro Hara; Shizue Tani-Ichi; Koichi Ikuta; Yoshitaka Okamoto; Toshinori Nakayama
Journal:  Proc Natl Acad Sci U S A       Date:  2016-05-02       Impact factor: 11.205

8.  IL-7-producing stromal cells are critical for lymph node remodeling.

Authors:  Lucas Onder; Priyanka Narang; Elke Scandella; Qian Chai; Maria Iolyeva; Kerim Hoorweg; Cornelia Halin; Ellen Richie; Paul Kaye; Jürgen Westermann; Tom Cupedo; Mark Coles; Burkhard Ludewig
Journal:  Blood       Date:  2012-09-06       Impact factor: 22.113

9.  Do CD8 effector cells need IL-7R expression to become resting memory cells?

Authors:  Eva Buentke; Anne Mathiot; Mauro Tolaini; James Di Santo; Rose Zamoyska; Benedict Seddon
Journal:  Blood       Date:  2006-05-16       Impact factor: 22.113

10.  Seeing is believing: illuminating the source of in vivo interleukin-7.

Authors:  Grace Yoonhee Kim; Changwan Hong; Jung-Hyun Park
Journal:  Immune Netw       Date:  2011-02-28       Impact factor: 6.303
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  69 in total

Review 1.  It Takes Three Receptors to Raise a B Cell.

Authors:  Kaitlin C McLean; Malay Mandal
Journal:  Trends Immunol       Date:  2020-05-22       Impact factor: 16.687

Review 2.  Genetics and functional genomics of multiple sclerosis.

Authors:  Woori Kim; Nikolaos A Patsopoulos
Journal:  Semin Immunopathol       Date:  2022-01-12       Impact factor: 9.623

Review 3.  Dynamic Roles for IL-2-STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations.

Authors:  Devin M Jones; Kaitlin A Read; Kenneth J Oestreich
Journal:  J Immunol       Date:  2020-10-01       Impact factor: 5.422

4.  MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance.

Authors:  Jordy C G van der Zwet; Jessica G C A M Buijs-Gladdines; Valentina Cordo'; Donna O Debets; Willem K Smits; Zhongli Chen; Jelle Dylus; Guido J R Zaman; Maarten Altelaar; Koichi Oshima; Beat Bornhauser; Jean-Pierre Bourquin; Jan Cools; Adolfo A Ferrando; Josef Vormoor; Rob Pieters; Britta Vormoor; Jules P P Meijerink
Journal:  Leukemia       Date:  2021-05-18       Impact factor: 11.528

5.  ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses.

Authors:  Jun Hyung Sin; Sujit Kashyap; Dante Acenas; Jessica T Cortez; James Lee; Alexander Marson; Mehrdad Matloubian; Michael R Waterfield
Journal:  J Immunol       Date:  2022-02-02       Impact factor: 5.422

6.  In vitro responses to platelet-rich-plasma are associated with variable clinical outcomes in patients with knee osteoarthritis.

Authors:  Habib Zahir; Bijan Dehghani; Scott Rodeo; Miguel Otero; Xiaoning Yuan; Yurii Chinenov; Christine Kim; Alissa Burge; Reyna Bandhari; Daniel Nemirov; Patrick Fava; Peter Moley; Hollis Potter; Joseph Nguyen; Brian Halpern; Laura Donlin; Lionel Ivashkiv
Journal:  Sci Rep       Date:  2021-06-01       Impact factor: 4.379

7.  Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.

Authors:  Kerri R Thomas; Eric J Allenspach; Nathan D Camp; Michelle N Wray-Dutra; Socheath Khim; Anna Zielinska-Kwiatkowska; Andrew E Timms; Joseph P Loftus; H Denny Liggitt; Katia Georgopoulos; Sarah K Tasian; Richard G James; David J Rawlings
Journal:  Leukemia       Date:  2021-06-30       Impact factor: 11.528

8.  In vitro Interleukin-7 treatment partially rescues MAIT cell dysfunction caused by SARS-CoV-2 infection.

Authors:  Satanay Hubrack; Maryam Ali Al-Nesf; Nourhen Agrebi; Christophe Raynaud; Mohammed Abu Khattab; Merlin Thomas; Tayseer Ibrahim; Salma Taha; Said Dermime; Maysaloun Merhi; Michal Kulinski; Martin Steinhoff; Patrick Tang; Bernice Lo
Journal:  Sci Rep       Date:  2021-07-08       Impact factor: 4.379

9.  Pivotal factors associated with the immunosuppressive tumor microenvironment and melanoma metastasis.

Authors:  Chuan Zhang; Dan Dang; Lele Cong; Hongyan Sun; Xianling Cong
Journal:  Cancer Med       Date:  2021-06-22       Impact factor: 4.452

10.  Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases.

Authors:  Jennifer Vandooren; Rafaela Vaz Sousa Pereira; Estefania Ugarte-Berzal; Vasily Rybakin; Sam Noppen; Melissa R Stas; Eline Bernaerts; Eva Ganseman; Mieke Metzemaekers; Dominique Schols; Paul Proost; Ghislain Opdenakker
Journal:  Front Immunol       Date:  2021-06-30       Impact factor: 7.561
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