Takahiro Onuma1, Tamotsu Kamishima2, Tsuyoshi Shimamura3, Norio Kawamura4, Kenichiro Yamashita5, Kenneth Sutherland6, Hiroshi Takeda7. 1. Department of Radiology, National Hospital Organization Hokkaido Medical Center, Sapporo, Hokkaido, Japan. 2. Faculty of Health Sciences, Hokkaido University, Sapporo, Hokkaido, Japan. 3. Department of Organ Transplantation, Hokkaido University Hospital, Sapporo, Hokkaido, Japan. 4. Department of Gastroenterological Surgery 1, Hokkaido University Hospital, Sapporo, Hokkaido, Japan. 5. Department of Transplant Surgery, Hokkaido University School of Medicine, Sapporo, Hokkaido, Japan. 6. Global Station for Medical Science and Engineering, Global Institution for Collaborative Research and Education (GI-CoRE), Hokkaido University, Hokkaido, Japan. 7. Department of Pathophysiology and Therapeutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido, Japan.
Abstract
BACKGROUND: The quantity and quality of skeletal muscle have been observed to be closely related with post-transplantation mortality in patients undergoing living donor liver transplantation (LDLT). However, the effect of LDLT on skeletal muscle has not been thoroughly investigated. The aim of this study was to investigate the change of trunk muscle mass and adiposity in recipients of LDLT. METHODS: The study population included LDLT recipients at Hokkaido University Hospital who underwent pre- and post-operative computed tomography (CT) scans (31 recipients; 14 males, and 17 females). The cross-sectional area of the dorsal muscle group at the 12th thoracic vertebra (Th12) was measured with the dorsal muscle group mass index (DMGMI), while the psoas muscle at the upper border of 4th lumber vertebra (L4) was measured with the psoas muscle mass index (PMI). Muscle adiposity of the dorsal muscle group was also measured with the intramuscular adipose tissue content (IMAC). For these data, the correlation between pre-operative values and follow-up changes (post-operative values minus pre-operative values) were analyzed. Each sex was evaluated separately. RESULTS: A statistically significant correlation was detected between pre-operative values and follow-up differences in DMGMI for both sexes (male: r=-0.675, P=0.008; female: r=-0.687, P=0.002) and in PMI for both sexes (males: r=-0.739, P=0.003; females: r=-0.641, P=0.006). The correlation of pre-operative values and follow-up differences for IMAC was not statistically significant with r=0.132 (P=0.700) and r=-0.498 (P=0.071) for males and females, respectively. CONCLUSIONS: Improvement of sarcopenia in recipients of LDLT can be demonstrated regardless of sex using volumetric CT.
BACKGROUND: The quantity and quality of skeletal muscle have been observed to be closely related with post-transplantation mortality in patients undergoing living donor liver transplantation (LDLT). However, the effect of LDLT on skeletal muscle has not been thoroughly investigated. The aim of this study was to investigate the change of trunk muscle mass and adiposity in recipients of LDLT. METHODS: The study population included LDLT recipients at Hokkaido University Hospital who underwent pre- and post-operative computed tomography (CT) scans (31 recipients; 14 males, and 17 females). The cross-sectional area of the dorsal muscle group at the 12th thoracic vertebra (Th12) was measured with the dorsal muscle group mass index (DMGMI), while the psoas muscle at the upper border of 4th lumber vertebra (L4) was measured with the psoas muscle mass index (PMI). Muscle adiposity of the dorsal muscle group was also measured with the intramuscular adipose tissue content (IMAC). For these data, the correlation between pre-operative values and follow-up changes (post-operative values minus pre-operative values) were analyzed. Each sex was evaluated separately. RESULTS: A statistically significant correlation was detected between pre-operative values and follow-up differences in DMGMI for both sexes (male: r=-0.675, P=0.008; female: r=-0.687, P=0.002) and in PMI for both sexes (males: r=-0.739, P=0.003; females: r=-0.641, P=0.006). The correlation of pre-operative values and follow-up differences for IMAC was not statistically significant with r=0.132 (P=0.700) and r=-0.498 (P=0.071) for males and females, respectively. CONCLUSIONS: Improvement of sarcopenia in recipients of LDLT can be demonstrated regardless of sex using volumetric CT.
Authors: Neda Amini; Gaya Spolverato; Rohan Gupta; Georgios A Margonis; Yuhree Kim; Doris Wagner; Neda Rezaee; Matthew J Weiss; Christopher L Wolfgang; Martin M Makary; Ihab R Kamel; Timothy M Pawlik Journal: J Gastrointest Surg Date: 2015-04-30 Impact factor: 3.452
Authors: Peter Peng; Omar Hyder; Amin Firoozmand; Peter Kneuertz; Richard D Schulick; Donghang Huang; Martin Makary; Kenzo Hirose; Barish Edil; Michael A Choti; Joseph Herman; John L Cameron; Christopher L Wolfgang; Timothy M Pawlik Journal: J Gastrointest Surg Date: 2012-06-13 Impact factor: 3.452
Authors: Karine Marquis; Richard Debigaré; Yves Lacasse; Pierre LeBlanc; Jean Jobin; Guy Carrier; François Maltais Journal: Am J Respir Crit Care Med Date: 2002-09-15 Impact factor: 21.405
Authors: Alfonso J Cruz-Jentoft; Jean Pierre Baeyens; Jürgen M Bauer; Yves Boirie; Tommy Cederholm; Francesco Landi; Finbarr C Martin; Jean-Pierre Michel; Yves Rolland; Stéphane M Schneider; Eva Topinková; Maurits Vandewoude; Mauro Zamboni Journal: Age Ageing Date: 2010-04-13 Impact factor: 10.668
Authors: Michael J Englesbe; Jay S Lee; Kevin He; Ludi Fan; Douglas E Schaubel; Kyle H Sheetz; Calista M Harbaugh; Sven A Holcombe; Darrel A Campbell; Christopher J Sonnenday; Stewart C Wang Journal: Ann Surg Date: 2012-08 Impact factor: 12.969