Literature DB >> 29537141

Cosmetic results of enucleation and/or external beam radiation therapy in 195 retinoblastoma survivors.

Daphne L Mourits1, Dyonne T Hartong1, Birgit I Lissenberg-Witte2, Machteld I Bosscha1, H Stevie Tan1, Annette C Moll1.   

Abstract

PURPOSE: To report the cosmetic outcome and late effects of enucleation and/or irradiation for retinoblastoma and to evaluate the role of orbital implants.
METHODS: Patients (age >4 years) enucleated and/or irradiated for retinoblastoma, visiting the hospital for routine follow-up (April 2013 to May 2015), were included in our cross-sectional study. Data were obtained via clinical records, questionnaires, physical measurements and standardized photographs. Two independent observers scored the cosmetic features: upper eyelid position, lower eyelid position, volume deficiency, and prosthesis motility and overall cosmetic appearance.
RESULTS: A total of 195 patients participated. Ptosis was seen in 45 (28.3%) patients, lower lid sagging in 45 (28.3%). Both complications were associated with the orbital implant; ptosis being more common with increasing implant size (5.6% without implant, 16.7% with small implant, 37.1% with medium implant and 76.9% with large implant) and lower lid sagging being more common in patients without implant (20% with implant versus 37.5% without). Volume loss of the superior sulcus was seen in 107 sockets (66.9%), most frequent in additionally irradiated patients (χ2 (2) = 42.7, p < 0.001) and in patients without implant (χ2 (2) = 11.92, p = 0.003). Prosthesis motility was better in patients with orbital implant, regardless of the size.
CONCLUSION: Minor late and potentially treatable effects were seen in patients with implant. Larger sized implants were associated with a higher incidence of ptosis; implant size did not affect subjective outcome with respect to volume or prosthetic motility. Treatment with EBRT had a less favourable outcome.
© 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  enucleation; external beam radiation therapy; late effects; orbital implant; ptosis; retinoblastoma

Mesh:

Year:  2018        PMID: 29537141     DOI: 10.1111/aos.13729

Source DB:  PubMed          Journal:  Acta Ophthalmol        ISSN: 1755-375X            Impact factor:   3.761


  3 in total

1.  Impact of enucleation on adult retinoblastoma survivors' quality of life: A qualitative study of survivors' perspectives.

Authors:  Smita C Banerjee; Elaine Pottenger; Mary Petriccione; Joanne F Chou; Jennifer S Ford; Charles A Sklar; Leslie L Robison; Ruth A Kleinerman; Kevin C Oeffinger; Jasmine H Francis; David H Abramson; Ira J Dunkel; Danielle Novetsky Friedman
Journal:  Palliat Support Care       Date:  2020-06

2.  Association between Subjective and Objective Assessment of Enucleation Outcome Depending on the Presence of an Orbital Implant in Patients with Uveal Melanoma.

Authors:  Weronika Pociej-Marciak; Bożena Romanowska-Dixon; Katarzyna Żuber-Łaskawiec; Mojca Globočnik Petrovič; Izabella Karska-Basta
Journal:  J Clin Med       Date:  2022-04-12       Impact factor: 4.964

3.  Quality of Life (QoL) and Psychosocial Outcomes in Adult Survivors of Unilateral Retinoblastoma (RB) in China.

Authors:  Yiyi Feng; Chuandi Zhou; Renbing Jia; Yefei Wang; Xianqun Fan
Journal:  J Ophthalmol       Date:  2020-03-12       Impact factor: 1.909

  3 in total

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