Literature DB >> 29536308

Phospholipase A2 Inhibitors Modulate the Effect of Trifluoperazine on the Intracellular Ca2+ Concentration in Macrophages.

Z I Krutetskaya1, L S Milenina2, A A Naumova2, S N Butov2, V G Antonov2, A D Nozdrachev2.   

Abstract

Using Fura-2AM microfluorimetry, it was shown for the first time that phospholipase A2 inhibitors 4-bromophenacyl bromide and glucocorticosteroids prednisolone and dexamethasone attenuate Ca2+ responses induced by neuroleptic trifluoperazine in macrophages. The results suggest the involvement of phospholipase A2 and arachidonic acid metabolism cascade in the effect of trifluoperazine on intracellular Ca2+ concentration in macrophages.

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Year:  2018        PMID： 29536308     DOI： 10.1134/S1607672918010118

Source DB:  PubMed          Journal:  Dokl Biochem Biophys        ISSN： 1607-6729            Impact factor:   0.788


  11 in total

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Journal:  J Chem Biol       Date:  2010-01-27

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Journal:  J Biol Chem       Date:  1985-03-25       Impact factor: 5.157

6.  Effect of phenothiazines on protein kinase C- and calcium-dependent activation of peritoneal macrophages.

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Journal:  Cell Biol Toxicol       Date:  2003-02       Impact factor: 6.691

7.  Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells.

Authors:  Qiang Xie; Yan Zhang; Changbin Zhai; Joseph A Bonanno
Journal:  J Biol Chem       Date:  2002-02-26       Impact factor: 5.157

8.  [THE EFFECT OF EPOXYGENASE INHIBITORS ON Ca(2+)-RESPONSES INDUCED BY GLUTOXIM AND MOLIXAN IN MACROPHAGES].

Authors:  L S Milenina; Z I Krutetskaya; A A Naumova; S N Butov; N I Krutetskaya; V G Antonov
Journal:  Tsitologiia       Date:  2015

9.  Dexamethasone down-regulates the 85 kDa phospholipase A2 in mouse macrophages and suppresses its activation.

Authors:  K Gewert; R Sundler
Journal:  Biochem J       Date:  1995-04-15       Impact factor: 3.857

Review 10.  Chemical structure of phenothiazines and their biological activity.

Authors:  Agata Jaszczyszyn; Kazimierz Gąsiorowski; Piotr Świątek; Wiesław Malinka; Katarzyna Cieślik-Boczula; Joanna Petrus; Bogusława Czarnik-Matusewicz
Journal:  Pharmacol Rep       Date:  2012       Impact factor: 3.024
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