Literature DB >> 22580516

Chemical structure of phenothiazines and their biological activity.

Agata Jaszczyszyn1, Kazimierz Gąsiorowski, Piotr Świątek, Wiesław Malinka, Katarzyna Cieślik-Boczula, Joanna Petrus, Bogusława Czarnik-Matusewicz.   

Abstract

Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their precursor in the world of natural compounds. Apart from their fundamental neuroleptic action connected with the dopaminergic receptors blockade, phenothiazine derivatives also exert diverse biological activities, which account for their cancer chemopreventive-effect, as: calmodulin- and protein kinase C inhibitory-actions, anti-proliferative effect, inhibition of P-glycoprotein transport function and reversion of multidrug resistance. According to literature data on relations between chemical structure of phenothiazines and their biological effects, the main directions for further chemical modifications have been established. They are provided and discussed in this review paper.

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Year:  2012        PMID： 22580516     DOI： 10.1016/s1734-1140(12)70726-0

Source DB:  PubMed          Journal:  Pharmacol Rep        ISSN： 1734-1140            Impact factor:   3.024


  28 in total

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