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Literature DB >> 2953304

In vitro activity of Ro 15-8074, Ro 19-5247, A-56268, and roxithromycin (RU 28965) against Neisseria gonorrhoeae and Chlamydia trachomatis.

W R Bowie, C E Shaw, D G Chan, W A Black.

Abstract

In vitro Ro 15-8074 and Ro 19-5247 (T2525), two new oral cephalosporins, were active against 410 penicillin-susceptible and -resistant isolates of Neisseria gonorrhoeae. Two new macrolides, A-56268 and to a lesser extent roxithromycin (RU 28965), were active against Chlamydia trachomatis. A-56268 had activity against N. gonorrhoeae similar to that of erythromycin.

Entities: Chemical Disease Species

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Year: 1987 PMID： 2953304 PMCID： PMC174756 DOI： 10.1128/AAC.31.3.470

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

7 in total

1. In-vitro susceptibility of 400 isolates of Neisseria gonorrhoeae in Vancouver, 1982-84.

Authors: W R Bowie; C E Shaw; D G Chan; H D Jones; W A Black
Journal: CMAJ Date: 1986-09-01 Impact factor: 8.262

2. In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.

Authors: W S Ng; P Y Chau; Y K Leung; P C Wong
Journal: Antimicrob Agents Chemother Date: 1985-09 Impact factor: 5.191

3. Rapid penicillinase paper strip test for detection of beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae.

Authors: J H Jorgensen; J C Lee; G A Alexander
Journal: Antimicrob Agents Chemother Date: 1977-06 Impact factor: 5.191

4. Relative resistance to erythromycin in Chlamydia trachomatis.

Authors: A Mourad; R L Sweet; N Sugg; J Schachter
Journal: Antimicrob Agents Chemother Date: 1980-11 Impact factor: 5.191

5. In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs.

Authors: R N Jones; A L Barry; C Thornsberry
Journal: Antimicrob Agents Chemother Date: 1983-08 Impact factor: 5.191

6. Efficacy of treatment regimens for lower urogenital Chlamydia trachomatis infection in women.

Authors: W R Bowie; L M Manzon; C J Borrie-Hume; A Fawcett; H D Jones
Journal: Am J Obstet Gynecol Date: 1982-01-15 Impact factor: 8.661

7. Prediction of efficacy of antimicrobial agents in treatment of infections due to Chlamydia trachomatis.

Authors: W R Bowie; C K Lee; E R Alexander
Journal: J Infect Dis Date: 1978-11 Impact factor: 5.226

7 in total

14 in total

In vitro activity of Ro 15-8074, Ro 19-5247, A-56268, and roxithromycin (RU 28965) against Neisseria gonorrhoeae and Chlamydia trachomatis.

1. In-vitro susceptibility of 400 isolates of Neisseria gonorrhoeae in Vancouver, 1982-84.

2. In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.

3. Rapid penicillinase paper strip test for detection of beta-lactamase-producing Haemophilus influenzae and Neisseria gonorrhoeae.

4. Relative resistance to erythromycin in Chlamydia trachomatis.

5. In vitro evaluation of three new macrolide antimicrobial agents, RU28965, RU29065, and RU29702, and comparisons with other orally administered drugs.

6. Efficacy of treatment regimens for lower urogenital Chlamydia trachomatis infection in women.

7. Prediction of efficacy of antimicrobial agents in treatment of infections due to Chlamydia trachomatis.

Review 1. New directions for macrolide antibiotics: structural modifications and in vitro activity.

2. Roxithromycin treatment of mouse chlamydial salpingitis and protective effect on fertility.

3. Rapid determination of MICs of 15 antichlamydial agents by using an enzyme immunoassay (Chlamydiazyme).

4. Effects of cefetamet (Ro 15-8074) on Treponema pallidum and experimental syphilis.

5. Dose-ranging study of fleroxacin for treatment of uncomplicated Chlamydia trachomatis genital infections.

Review 6. Cefetamet pivoxil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Review 7. Cefetamet pivoxil clinical pharmacokinetics.

Review 8. Clarithromycin clinical pharmacokinetics.

9. In vitro activity of dirithromycin against Chlamydia trachomatis.

10. Penetration of cefprozil into middle ear fluid of patients with otitis media.