Anabelle Retondario1, Ricardo Fernandes2, Gabriele Rockenbach3, Mariane de Almeida Alves4, Liliana Paula Bricarello2, Erasmo Benicio Santos de Moraes Trindade5, Francisco de Assis Guedes de Vasconcelos5. 1. Federal University of Santa Catarina (UFSC, Portuguese Acronym for Universidade Federal de Santa Catarina), Postgraduate Program in Nutrition, CAPES [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior] Scholarship, Florianópolis, Santa Catarina, Brazil. Electronic address: profe.anabelle@gmail.com. 2. Federal University of Santa Catarina (UFSC, Portuguese Acronym for Universidade Federal de Santa Catarina), Postgraduate Program in Nutrition, CAPES [Coordenação de Aperfeiçoamento de Pessoal de Nível Superior] Scholarship, Florianópolis, Santa Catarina, Brazil. 3. Federal University of Santa Catarina (UFSC), Nutrition Department, Florianópolis, Santa Catarina, Brazil. 4. Federal University of Santa Catarina (UFSC), Postgraduate Program in Nutrition, FAPESC [Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina] Scholarship, Florianópolis, Santa Catarina, Brazil. 5. Federal University of Santa Catarina (UFSC), Postgraduate Program in Nutrition, Florianópolis, Santa Catarina, Brazil.
Abstract
BACKGROUND & AIMS: Metabolic syndrome is a multi-causal disease. Its treatment includes lifestyle changes with a focus on weight loss. This systematic review assessed the association between Selenium intake and metabolic syndrome. METHODS: Data were collected mainly from four databases: PubMed, CENTRAL (Cochrane), Scopus and Web of Knowledge. Keywords related to metabolic syndrome, selenium, as well as metabolic syndrome features were searched. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. A systematic review protocol was registered at PROSPERO (n. 42016046321). Two reviewers independently screened 2957 abstracts. Six studies were included to perform data extraction with standardized spreadsheets. The risk of bias was assessed by using specific tools according to the design of the relevant studies. An assessment was carried out based on the appropriateness of the study reports accordingly to STROBE and the CONSORT-based checklist for each study design. RESULTS: Three studies found no association between Selenium intake and metabolic syndrome; two of them found an inverse association; and one study found a direct association between Selenium intake and metabolic syndrome. One study also showed an inverse association between Selenium intake and the prevalence of high waist circumference, high diastolic blood pressure, and hyperglycaemia in women. CONCLUSIONS: Overall, based on the argumentation and results of this study, it is possible to conclude that Selenium intake and metabolic syndrome are not clearly associated in adults and elderly.
BACKGROUND & AIMS:Metabolic syndrome is a multi-causal disease. Its treatment includes lifestyle changes with a focus on weight loss. This systematic review assessed the association between Selenium intake and metabolic syndrome. METHODS: Data were collected mainly from four databases: PubMed, CENTRAL (Cochrane), Scopus and Web of Knowledge. Keywords related to metabolic syndrome, selenium, as well as metabolic syndrome features were searched. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. A systematic review protocol was registered at PROSPERO (n. 42016046321). Two reviewers independently screened 2957 abstracts. Six studies were included to perform data extraction with standardized spreadsheets. The risk of bias was assessed by using specific tools according to the design of the relevant studies. An assessment was carried out based on the appropriateness of the study reports accordingly to STROBE and the CONSORT-based checklist for each study design. RESULTS: Three studies found no association between Selenium intake and metabolic syndrome; two of them found an inverse association; and one study found a direct association between Selenium intake and metabolic syndrome. One study also showed an inverse association between Selenium intake and the prevalence of high waist circumference, high diastolic blood pressure, and hyperglycaemia in women. CONCLUSIONS: Overall, based on the argumentation and results of this study, it is possible to conclude that Selenium intake and metabolic syndrome are not clearly associated in adults and elderly.