Literature DB >> 29523692

Membrane protein serendipity.

Gunnar von Heijne1,2.   

Abstract

My scientific career has taken me from chemistry, via theoretical physics and bioinformatics, to molecular biology and even structural biology. Along the way, serendipity led me to work on problems such as the identification of signal peptides that direct protein trafficking, membrane protein biogenesis, and cotranslational protein folding. I've had some great collaborations that came about because of a stray conversation or from following up on an interesting paper. And I've had the good fortune to be asked to sit on the Nobel Committee for Chemistry, where I am constantly reminded of the amazing pace and often intricate history of scientific discovery. Could I have planned this? No way! I just went with the flow ….
© 2018 von Heijne.

Keywords:  La Recherche; bioinformatics; membrane biophysics; membrane protein; membrane structure; protein structure; protein trafficking

Mesh:

Substances:

Year:  2018        PMID: 29523692      PMCID: PMC5846136          DOI: 10.1074/jbc.X118.001958

Source DB:  PubMed          Journal:  J Biol Chem        ISSN: 0021-9258            Impact factor:   5.157


  40 in total

1.  Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.

Authors:  A Krogh; B Larsson; G von Heijne; E L Sonnhammer
Journal:  J Mol Biol       Date:  2001-01-19       Impact factor: 5.469

2.  Control of membrane protein topology by a single C-terminal residue.

Authors:  Susanna Seppälä; Joanna S Slusky; Pilar Lloris-Garcerá; Mikaela Rapp; Gunnar von Heijne
Journal:  Science       Date:  2010-05-27       Impact factor: 47.728

3.  Cotranslational protein folding on the ribosome monitored in real time.

Authors:  Wolf Holtkamp; Goran Kokic; Marcus Jäger; Joerg Mittelstaet; Anton A Komar; Marina V Rodnina
Journal:  Science       Date:  2015-11-27       Impact factor: 47.728

Review 4.  Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.

Authors:  Tom A Rapoport
Journal:  Nature       Date:  2007-11-29       Impact factor: 49.962

5.  Locating proteins in the cell using TargetP, SignalP and related tools.

Authors:  Olof Emanuelsson; Søren Brunak; Gunnar von Heijne; Henrik Nielsen
Journal:  Nat Protoc       Date:  2007       Impact factor: 13.491

6.  Trans-membrane translocation of proteins. The direct transfer model.

Authors:  G von Heijne; C Blomberg
Journal:  Eur J Biochem       Date:  1979-06

7.  A scalable, GFP-based pipeline for membrane protein overexpression screening and purification.

Authors:  David Drew; Dirk-Jan Slotboom; Giulia Friso; Torsten Reda; Pierre Genevaux; Mikaela Rapp; Nadja M Meindl-Beinker; Wietske Lambert; Mirjam Lerch; Daniel O Daley; Klaas-Jan Van Wijk; Judy Hirst; Edmund Kunji; Jan-Willem De Gier
Journal:  Protein Sci       Date:  2005-06-29       Impact factor: 6.725

Review 8.  Lipid-dependent membrane protein topogenesis.

Authors:  William Dowhan; Mikhail Bogdanov
Journal:  Annu Rev Biochem       Date:  2009       Impact factor: 23.643

9.  The distribution of positively charged residues in bacterial inner membrane proteins correlates with the trans-membrane topology.

Authors:  G Heijne
Journal:  EMBO J       Date:  1986-11       Impact factor: 11.598

10.  A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding.

Authors:  Lisa D Cabrita; AnaÏs M E Cassaignau; Helene M M Launay; Christopher A Waudby; Tomasz Wlodarski; Carlo Camilloni; Maria-Evangelia Karyadi; Amy L Robertson; Xiaolin Wang; Anne S Wentink; Luke Goodsell; Cheryl A Woolhead; Michele Vendruscolo; Christopher M Dobson; John Christodoulou
Journal:  Nat Struct Mol Biol       Date:  2016-02-29       Impact factor: 15.369

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