John Whitaker1,2, Cory M Tschabrunn1, Jihye Jang1, Eran Leshem1, Mark O'Neill2, Warren J Manning1, Elad Anter1, Reza Nezafat1. 1. Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. 2. Division of Imaging Sciences and Biomedical Engineering, King's College, London, UK.
Abstract
BACKGROUND: Myocardial infarction (MI) survivors are at risk of complications including heart failure and malignant arrhythmias. PURPOSE: We undertook serial imaging of swine following MI with the aim of characterizing the longitudinal left ventricular (LV) remodeling in a translational model of ischemia-reperfusion-mediated MI. ANIMAL MODEL: Eight Yorkshire swine underwent mid left anterior descending coronary artery balloon occlusion to create an ischemia-reperfusion experimental model of MI. FIELD STRENGTH/SEQUENCES: 1.5T Philips Achieva scanner. Serial cardiac MRI was performed at 16, 33, and 62 days post-MI, including cine imaging, native and postcontrast T1 , T2 and dark-blood late gadolinium enhanced (DB-LGE) scar imaging. ASSESSMENT: Regions of interest were selected on the parametric maps to assess native T1 and T2 in the infarct and in remote tissue. Volume of enhanced tissue, nonenhanced tissue, and gray zone were assessed from DB-LGE imaging. Volumes, cardiac function, and strain were calculated from cine imaging. STATISTICAL TESTS: Parameters estimated at more than two timepoints were compared with a one-way repeated measures analysis of variance. Parametric mapping data were analyzed using a generalized linear mixed model corrected for multiple observations. A result was considered statistically significant at P < 0.05. RESULTS: All animals developed anteroseptal akinesia and hyperenhancement on DB-LGE with a central core of nonenhancing tissue. Mean hyperenhancement volume did not change during the observation period, while the central core contracted from 2.2 ± 1.8 ml at 16 days to 0.08 ± 0.19 ml at 62 days (P = 0.008). Native T1 of ischemic myocardium increased from 1173 ± 93 msec at 16 days to 1309 ± 97 msec at 62 days (P < 0.001). Mean radial and circumferential strain rate magnitude in remote myocardium increased with time from the infarct (P < 0.05). DATE CONCLUSION: In this swine model of MI, serial quantitative cardiac MR exams allow characterization of LV remodeling and scar formation. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.
BACKGROUND: Myocardial infarction (MI) survivors are at risk of complications including heart failure and malignant arrhythmias. PURPOSE: We undertook serial imaging of swine following MI with the aim of characterizing the longitudinal left ventricular (LV) remodeling in a translational model of ischemia-reperfusion-mediated MI. ANIMAL MODEL: Eight Yorkshire swine underwent mid left anterior descending coronary artery balloon occlusion to create an ischemia-reperfusion experimental model of MI. FIELD STRENGTH/SEQUENCES: 1.5T Philips Achieva scanner. Serial cardiac MRI was performed at 16, 33, and 62 days post-MI, including cine imaging, native and postcontrast T1 , T2 and dark-blood late gadolinium enhanced (DB-LGE) scar imaging. ASSESSMENT: Regions of interest were selected on the parametric maps to assess native T1 and T2 in the infarct and in remote tissue. Volume of enhanced tissue, nonenhanced tissue, and gray zone were assessed from DB-LGE imaging. Volumes, cardiac function, and strain were calculated from cine imaging. STATISTICAL TESTS: Parameters estimated at more than two timepoints were compared with a one-way repeated measures analysis of variance. Parametric mapping data were analyzed using a generalized linear mixed model corrected for multiple observations. A result was considered statistically significant at P < 0.05. RESULTS: All animals developed anteroseptal akinesia and hyperenhancement on DB-LGE with a central core of nonenhancing tissue. Mean hyperenhancement volume did not change during the observation period, while the central core contracted from 2.2 ± 1.8 ml at 16 days to 0.08 ± 0.19 ml at 62 days (P = 0.008). Native T1 of ischemic myocardium increased from 1173 ± 93 msec at 16 days to 1309 ± 97 msec at 62 days (P < 0.001). Mean radial and circumferential strain rate magnitude in remote myocardium increased with time from the infarct (P < 0.05). DATE CONCLUSION: In this swine model of MI, serial quantitative cardiac MR exams allow characterization of LV remodeling and scar formation. LEVEL OF EVIDENCE: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.
Authors: John Whitaker; Radhouene Neji; Steven Kim; Adam Connolly; Thierry Aubriot; Justo Juliá Calvo; Rashed Karim; Caroline H Roney; Brendan Murfin; Carla Richardson; Stephen Morgan; Tevfik F Ismail; James Harrison; Judith de Vos; Maurice C G Aalders; Steven E Williams; Rahul Mukherjee; Louisa O'Neill; Henry Chubb; Cory Tschabrunn; Elad Anter; Luigi Camporota; Steven Niederer; Sébastien Roujol; Martin J Bishop; Matthew Wright; John Silberbauer; Reza Razavi; Mark O'Neill Journal: Front Cardiovasc Med Date: 2021-10-26
Authors: Caroline Mendonca Costa; Philip Gemmell; Mark K Elliott; John Whitaker; Fernando O Campos; Marina Strocchi; Aurel Neic; Karli Gillette; Edward Vigmond; Gernot Plank; Reza Razavi; Mark O'Neill; Christopher A Rinaldi; Martin J Bishop Journal: Comput Biol Med Date: 2021-11-26 Impact factor: 4.589
Authors: Craig C Morris; Jacob Ref; Satya Acharya; Kevin J Johnson; Scott Squire; Tuschar Acharya; Tyler Dennis; Sherry Daugherty; Alice McArthur; Ikeotunye Royal Chinyere; Jen Watson Koevary; Joshua M Hare; Jordan J Lancaster; Steven Goldman; Ryan Avery Journal: Sci Rep Date: 2022-03-08 Impact factor: 4.379
Authors: Dinesh Selvakumar; Tejas Deshmukh; Sheryl L Foster; Naeim N Sanaei; Anthea L L Min; Stuart M Grieve; Faraz Pathan; James J H Chong Journal: Sci Rep Date: 2022-03-08 Impact factor: 4.379