Literature DB >> 29519865

Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia.

Yiping Zhu1, Dandan Yin2, Yali Su1, Xuyang Xia2, Takaya Moriyama3, Rina Nishii3, Fei Liao2, Shouyue Zhang2, Xia Guo1, Qianqian Hou2, Yuan Ai1, Xueyan Zhou2, Shuwen Sun1, Duyu Zhang2, Yan Zhang4, Chao Lin1, Yiqi Deng2, Xiaoxi Lu1, Yuelan Wang2, Zhigui Ma1, Heyao Wang5, Bo Liu6, Li Yang6, Wei Zhang7, Jun J Yang3, Yang Shu8, Ju Gao9, Heng Xu8.   

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Year:  2018        PMID： 29519865      PMCID： PMC6029522          DOI： 10.3324/haematol.2018.187658

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


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  15 in total

1.  NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia.

Authors:  Kanhatai Chiengthong; Chupong Ittiwut; Sasipa Muensri; Jiratchaya Sophonphan; Darintr Sosothikul; Panya Seksan; Koramit Suppipat; Kanya Suphapeetiporn; Vorasuk Shotelersuk
Journal:  Haematologica       Date:  2015-09-24       Impact factor: 9.941

2.  NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity.

Authors:  Takaya Moriyama; Rina Nishii; Virginia Perez-Andreu; Wenjian Yang; Federico Antillon Klussmann; Xujie Zhao; Ting-Nien Lin; Keito Hoshitsuki; Jacob Nersting; Kentaro Kihira; Ute Hofmann; Yoshihiro Komada; Motohiro Kato; Robert McCorkle; Lie Li; Katsuyoshi Koh; Cesar Rolando Najera; Shirley Kow-Yin Kham; Tomoya Isobe; Zhiwei Chen; Edwynn Kean-Hui Chiew; Deepa Bhojwani; Cynthia Jeffries; Yan Lu; Matthias Schwab; Hiroto Inaba; Ching-Hon Pui; Mary V Relling; Atsushi Manabe; Hiroki Hori; Kjeld Schmiegelow; Allen E J Yeoh; William E Evans; Jun J Yang
Journal:  Nat Genet       Date:  2016-02-15       Impact factor: 38.330

3.  Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia.

Authors:  Yoichi Tanaka; Motohiro Kato; Daisuke Hasegawa; Kevin Y Urayama; Hisaya Nakadate; Kensuke Kondoh; Kozue Nakamura; Katsuyoshi Koh; Takako Komiyama; Atsushi Manabe
Journal:  Br J Haematol       Date:  2015-06-02       Impact factor: 6.998

4.  Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus.

Authors:  M V Relling; M L Hancock; G K Rivera; J T Sandlund; R C Ribeiro; E Y Krynetski; C H Pui; W E Evans
Journal:  J Natl Cancer Inst       Date:  1999-12-01       Impact factor: 13.506

5.  ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia.

Authors:  Heng Xu; Cheng Cheng; Meenakshi Devidas; Deqing Pei; Yiping Fan; Wenjian Yang; Geoff Neale; Paul Scheet; Esteban G Burchard; Dara G Torgerson; Celeste Eng; Michael Dean; Frederico Antillon; Naomi J Winick; Paul L Martin; Cheryl L Willman; Bruce M Camitta; Gregory H Reaman; William L Carroll; Mignon Loh; William E Evans; Ching-Hon Pui; Stephen P Hunger; Mary V Relling; Jun J Yang
Journal:  J Clin Oncol       Date:  2012-01-30       Impact factor: 44.544

6.  NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine.

Authors:  Nicholas C K Valerie; Anna Hagenkort; Brent D G Page; Geoffrey Masuyer; Daniel Rehling; Megan Carter; Luka Bevc; Patrick Herr; Evert Homan; Nina G Sheppard; Pål Stenmark; Ann-Sofie Jemth; Thomas Helleday
Journal:  Cancer Res       Date:  2016-08-16       Impact factor: 12.701

7.  Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry.

Authors:  Takaya Moriyama; Yung-Li Yang; Rina Nishii; Hany Ariffin; Chengcheng Liu; Ting-Nien Lin; Wenjian Yang; Dong-Tsamn Lin; Chih-Hsiang Yu; Shirley Kham; Ching-Hon Pui; William E Evans; Sima Jeha; Mary V Relling; Allen Eng-Juh Yeoh; Jun J Yang
Journal:  Blood       Date:  2017-06-28       Impact factor: 22.113

8.  Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.

Authors:  C Liu; W Yang; D Pei; C Cheng; C Smith; W Landier; L Hageman; Y Chen; J J Yang; K R Crews; N Kornegay; S E Karol; F L Wong; S Jeha; J T Sandlund; R C Ribeiro; J E Rubnitz; M L Metzger; C-H Pui; W E Evans; S Bhatia; M V Relling
Journal:  Clin Pharmacol Ther       Date:  2016-11-18       Impact factor: 6.875

9.  Germline genomic variants associated with childhood acute lymphoblastic leukemia.

Authors:  Lisa R Treviño; Wenjian Yang; Deborah French; Stephen P Hunger; William L Carroll; Meenakshi Devidas; Cheryl Willman; Geoffrey Neale; James Downing; Susana C Raimondi; Ching-Hon Pui; William E Evans; Mary V Relling
Journal:  Nat Genet       Date:  2009-08-16       Impact factor: 38.330

10.  Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.

Authors:  Heng Xu; Wenjian Yang; Virginia Perez-Andreu; Meenakshi Devidas; Yiping Fan; Cheng Cheng; Deqing Pei; Paul Scheet; Esteban González Burchard; Celeste Eng; Scott Huntsman; Dara G Torgerson; Michael Dean; Naomi J Winick; Paul L Martin; Bruce M Camitta; W Paul Bowman; Cheryl L Willman; William L Carroll; Charles G Mullighan; Deepa Bhojwani; Stephen P Hunger; Ching-Hon Pui; William E Evans; Mary V Relling; Mignon L Loh; Jun J Yang
Journal:  J Natl Cancer Inst       Date:  2013-03-19       Impact factor: 13.506
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  12 in total

1.  Precision therapy of 6-mercaptopurine in Chinese children with acute lymphoblastic leukaemia.

Authors:  Yue Zhou; Li Wang; Xiao-Ying Zhai; Li Wen; Fang Tang; Fan Yang; Xi-Ting Liu; Lei Dong; Li-Juan Zhi; Hai-Yan Shi; Guo-Xiang Hao; Yi Zheng; Evelyne Jacqz-Aigrain; Tian-You Wang; Wei Zhao
Journal:  Br J Clin Pharmacol       Date:  2020-03-03       Impact factor: 4.335

Review 2.  [Significance of NUDT15 gene in individualized treatment with 6-mercaptopurine in children with acute lymphoblastic leukemia].

Authors:  Jing He; Ling Liu
Journal:  Zhongguo Dang Dai Er Ke Za Zhi       Date:  2019-01

3.  Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update.

Authors:  Mary V Relling; Matthias Schwab; Michelle Whirl-Carrillo; Guilherme Suarez-Kurtz; Ching-Hon Pui; Charles M Stein; Ann M Moyer; William E Evans; Teri E Klein; Federico Guillermo Antillon-Klussmann; Kelly E Caudle; Motohiro Kato; Allen E J Yeoh; Kjeld Schmiegelow; Jun J Yang
Journal:  Clin Pharmacol Ther       Date:  2019-01-20       Impact factor: 6.875

4.  Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants.

Authors:  Der-Shiun Wang; Chih-Hsiang Yu; Chien-Yu Lin; Ya-Hsuan Chang; Kai-Hsin Lin; Dong-Tsamn Lin; Shiann-Tarng Jou; Meng-Yao Lu; Hsiu-Hao Chang; Shu-Wha Lin; Hsuan-Yu Chen; Yung-Li Yang
Journal:  Pediatr Res       Date:  2020-03-27       Impact factor: 3.756

5.  Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT.

Authors:  Yoomi Park; Hyery Kim; Heewon Seo; Jung Yoon Choi; Youngeun Ma; Sunmin Yun; Byung-Joo Min; Myung-Eui Seo; Keon Hee Yoo; Hyoung Jin Kang; Ho Joon Im; Ju Han Kim
Journal:  J Transl Med       Date:  2020-07-01       Impact factor: 5.531

6.  Associations between the NUDT15 R139C polymorphism and susceptibility to thiopurine-induced leukopenia in Asians: a meta-analysis.

Authors:  Yulan Liu; Yang Meng; Lu Wang; Zhou Liu; Jiao Li; Weiguo Dong
Journal:  Onco Targets Ther       Date:  2018-11-23       Impact factor: 4.147

7.  Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study.

Authors:  Zhao-Yang Chen; Yang-Hui Zhu; Ling-Yan Zhou; Wei-Qiao Shi; Zhou Qin; Bin Wu; Yu Yan; Yu-Wen Pei; Ning-Ning Chao; Rui Zhang; Mi-Ye Wang; Ze-Hao Su; Xiao-Jun Lu; Zhi-Yao He; Ting Xu
Journal:  Front Pharmacol       Date:  2021-05-18       Impact factor: 5.810

8.  Identification of NUDT15 gene variants in Amazonian Amerindians and admixed individuals from northern Brazil.

Authors:  Juliana Carla Gomes Rodrigues; Tatiane Piedade de Souza; Lucas Favacho Pastana; André Maurício Ribeiro Dos Santos; Marianne Rodrigues Fernandes; Pablo Pinto; Alayde Vieira Wanderley; Sandro José de Souza; José Eduardo Kroll; Adenilson Leão Pereira; Leandro Magalhães; Laís Reis das Mercês; Amanda Ferreira Vidal; Tatiana Vinasco-Sandoval; Giovanna Chaves Cavalcante; João Farias Guerreiro; Paulo Pimentel de Assumpção; Ândrea Ribeiro-Dos-Santos; Sidney Santos; Ney Pereira Carneiro Dos Santos
Journal:  PLoS One       Date:  2020-04-15       Impact factor: 3.240

9.  Screening of Novel Pharmacogenetic Candidates for Mercaptopurine-Induced Toxicity in Patients With Acute Lymphoblastic Leukemia.

Authors:  Minyuan Cao; Dandan Yin; Yun Qin; Fei Liao; Yali Su; Xuyang Xia; Ju Gao; Yiping Zhu; Wei Zhang; Yang Shu; Xiaoxi Lu
Journal:  Front Pharmacol       Date:  2020-03-20       Impact factor: 5.810

10.  Validations of Top and Novel Susceptibility Variants in All-Age Chinese Patients With Acute Lymphoblastic Leukemia.

Authors:  Fei Liao; Yuanxin Ye; Dandan Yin; Yun Qin; Jiangyan Zhao; Wanhua Zhang; Yan Zhang; Zhujun Deng; Yuelan Wang; Binwu Ying; Lanlan Wang; Ju Gao; Yang Shu; Yiping Zhu; Xiaoxi Lu
Journal:  Front Genet       Date:  2020-08-25       Impact factor: 4.599
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