Nesa Jafari1, Sonbol Nazeri2, Sattar Tahmasebi Enferadi3. 1. Department of Plant Biotechnology, Faculty of Agriculture, Bu-Ali Sina University, Hamadan, Iran; Departments of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran. 2. Department of Plant Biotechnology, Faculty of Agriculture, Bu-Ali Sina University, Hamadan, Iran. Electronic address: snazeri@basu.ac.ir. 3. Departments of Energy and Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Abstract
BACKGROUND: Use of pharmaceutical agent for breast cancer chemotherapy is an interesting method that induces cells death by different way, such as apoptosis. Parthenolide is the main compound in feverfew that has been used to cure migraine and rheumatoid arthritis for long time. Parthenolide has been predominately investigated as inducer of apoptosis in human cancer cells. PURPOSE: We examined the expression of vimentin and Elongation factor α - 1 as breast cancer biomarkers in MCF7 cells exposure to Parthenolide. METHOD: In this study, we investigated the antitumor mechanism of Parthenolide on the human breast cancer cell line MCF7, using SEM, flow cytometry and proteomics techniques. RESULT: Comparative proteome analyses are shown Elongation factor1-α and vimentin was suppressed in response to Parthenolide treatment.
BACKGROUND: Use of pharmaceutical agent for breast cancer chemotherapy is an interesting method that induces cells death by different way, such as apoptosis. Parthenolide is the main compound in feverfew that has been used to cure migraine and rheumatoid arthritis for long time. Parthenolide has been predominately investigated as inducer of apoptosis in humancancer cells. PURPOSE: We examined the expression of vimentin and Elongation factor α - 1 as breast cancer biomarkers in MCF7 cells exposure to Parthenolide. METHOD: In this study, we investigated the antitumor mechanism of Parthenolide on the humanbreast cancer cell line MCF7, using SEM, flow cytometry and proteomics techniques. RESULT: Comparative proteome analyses are shown Elongation factor1-α and vimentin was suppressed in response to Parthenolide treatment.
Authors: Charles A Berdan; Raymond Ho; Haley S Lehtola; Milton To; Xirui Hu; Tucker R Huffman; Yana Petri; Chad R Altobelli; Sasha G Demeulenaere; James A Olzmann; Thomas J Maimone; Daniel K Nomura Journal: Cell Chem Biol Date: 2019-05-09 Impact factor: 8.116
Authors: Wamidh H Talib; Dima Awajan; Reem Ali Hamed; Aya O Azzam; Asma Ismail Mahmod; Intisar Hadi Al-Yasari Journal: Molecules Date: 2022-08-25 Impact factor: 4.927