Jane J Lee1, Alison Pedley1, Udo Hoffmann2, Joseph M Massaro3, Daniel Levy4, Michelle T Long5. 1. Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Md; Framingham Heart Study, Framingham, Mass. 2. Department of Radiology, Massachusetts General Hospital, Boston, Mass. 3. Department of Biostatistics, Boston University, Boston, Mass. 4. Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Md; Framingham Heart Study, Framingham, Mass; Boston University School of Medicine, Boston, Mass. 5. Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Md; Framingham Heart Study, Framingham, Mass; Department of Medicine, Division of Gastroenterology, Boston University School of Medicine, Boston, Mass. Electronic address: mtlong@bu.edu.
Abstract
BACKGROUND: We examined the associations among 8 different fat depots accumulated in various anatomic regions and the relationship between these fat depots and multiple cardiometabolic risk factors. METHODS: Participants were from the Framingham Heart Study Offspring and Third Generation who also participated in the multidetector computed tomography substudy in 2002-2005. Exposures were multidetector computed tomography-derived fat depots, including abdominal subcutaneous adipose tissue, abdominal visceral adipose tissue, intramuscular fat, intrathoracic fat, pericardial fat, thoracic periaortic fat, intrahepatic fat, and renal sinus fat. Multivariable-adjusted regression analyses with a forward selection procedure were performed to identify the most predictive fat depots. RESULTS: Of 2529 participants, 51.9% were women (mean age, 51.1 years). Visceral adipose tissue had the strongest correlations with each of the other fat measures (range, 0.26-0.77) and with various cardiometabolic risk factors (range, -0.34 to 0.39). As determined by the selection models, visceral adipose tissue was the only fat depot that was associated with all cardiometabolic risk factors evaluated in this study (all P<.05). Selection models also showed that subcutaneous adipose tissue and intrahepatic fat were associated with cardiometabolic risk factors related to the traits of dysglycemia, dyslipidemia, and hypertension (all P<.05). However, only associations with visceral adipose tissue and intrahepatic fat persisted after further adjustment for body mass index and waist circumference. CONCLUSIONS: Visceral adipose tissue and intrahepatic fat were consistent correlates of cardiometabolic risk factors, above and beyond standard anthropometric indices. Our data provide important insights for understanding the associations between variations in fat distribution and cardiometabolic abnormalities. Published by Elsevier Inc.
BACKGROUND: We examined the associations among 8 different fat depots accumulated in various anatomic regions and the relationship between these fat depots and multiple cardiometabolic risk factors. METHODS:Participants were from the Framingham Heart Study Offspring and Third Generation who also participated in the multidetector computed tomography substudy in 2002-2005. Exposures were multidetector computed tomography-derived fat depots, including abdominal subcutaneous adipose tissue, abdominal visceral adipose tissue, intramuscular fat, intrathoracic fat, pericardial fat, thoracic periaortic fat, intrahepatic fat, and renal sinus fat. Multivariable-adjusted regression analyses with a forward selection procedure were performed to identify the most predictive fat depots. RESULTS: Of 2529 participants, 51.9% were women (mean age, 51.1 years). Visceral adipose tissue had the strongest correlations with each of the other fat measures (range, 0.26-0.77) and with various cardiometabolic risk factors (range, -0.34 to 0.39). As determined by the selection models, visceral adipose tissue was the only fat depot that was associated with all cardiometabolic risk factors evaluated in this study (all P<.05). Selection models also showed that subcutaneous adipose tissue and intrahepatic fat were associated with cardiometabolic risk factors related to the traits of dysglycemia, dyslipidemia, and hypertension (all P<.05). However, only associations with visceral adipose tissue and intrahepatic fat persisted after further adjustment for body mass index and waist circumference. CONCLUSIONS: Visceral adipose tissue and intrahepatic fat were consistent correlates of cardiometabolic risk factors, above and beyond standard anthropometric indices. Our data provide important insights for understanding the associations between variations in fat distribution and cardiometabolic abnormalities. Published by Elsevier Inc.
Authors: George Thanassoulis; Joseph M Massaro; Udo Hoffmann; Amir A Mahabadi; Ramachandran S Vasan; Christopher J O'Donnell; Caroline S Fox Journal: Circ Cardiovasc Imaging Date: 2010-06-04 Impact factor: 7.792
Authors: Sam J Lehman; Joseph M Massaro; Christopher L Schlett; Christopher J O'Donnell; Udo Hoffmann; Caroline S Fox Journal: Atherosclerosis Date: 2010-01-21 Impact factor: 5.162
Authors: Guido A Rosito; Joseph M Massaro; Udo Hoffmann; Frederick L Ruberg; Amir A Mahabadi; Ramachandran S Vasan; Christopher J O'Donnell; Caroline S Fox Journal: Circulation Date: 2008-01-22 Impact factor: 29.690
Authors: Jane J Lee; Alison Pedley; Udo Hoffmann; Joseph M Massaro; John F Keaney; Ramachandran S Vasan; Caroline S Fox Journal: J Am Heart Assoc Date: 2016-02-29 Impact factor: 5.501
Authors: Carolyn E Barlow; Kerem Shuval; Bijal A Balasubramanian; Darla E Kendzor; Nina B Radford; Laura F DeFina; Kelley Pettee Gabriel Journal: Prev Chronic Dis Date: 2016-12-29 Impact factor: 2.830
Authors: Iva Miljkovic; Allison L Kuipers; Ryan K Cvejkus; J Jeffrey Carr; James G Terry; Bharat Thyagarajan; Victor W Wheeler; Sangeeta Nair; Joseph M Zmuda Journal: Metab Syndr Relat Disord Date: 2020-05-11 Impact factor: 1.894
Authors: Tiffany M Powell-Wiley; Paul Poirier; Lora E Burke; Jean-Pierre Després; Penny Gordon-Larsen; Carl J Lavie; Scott A Lear; Chiadi E Ndumele; Ian J Neeland; Prashanthan Sanders; Marie-Pierre St-Onge Journal: Circulation Date: 2021-04-22 Impact factor: 29.690
Authors: Jacob A Goldsmith; Areej N Ennasr; Gary J Farkas; David R Gater; Ashraf S Gorgey Journal: Eur J Appl Physiol Date: 2021-04-23 Impact factor: 3.078
Authors: Hidemi Sorimachi; Masaru Obokata; Naoki Takahashi; Yogesh N V Reddy; Christopher C Jain; Frederik H Verbrugge; Katlyn E Koepp; Sundeep Khosla; Michael D Jensen; Barry A Borlaug Journal: Eur Heart J Date: 2021-04-21 Impact factor: 35.855
Authors: Sankar D Navaneethan; John P Kirwan; Erick M Remer; Erika Schneider; Bryan Addeman; Susana Arrigain; Ed Horwitz; Jeffrey C Fink; James P Lash; Charles A McKenzie; Mahboob Rahman; Panduranga S Rao; Jesse D Schold; Tariq Shafi; Jonathan J Taliercio; Raymond R Townsend; Harold I Feldman Journal: Am J Kidney Dis Date: 2020-08-13 Impact factor: 8.860
Authors: Kieran Smith; Guy S Taylor; Dean M Allerton; Lise Hoej Brunsgaard; Kelly A Bowden Davies; Emma J Stevenson; Daniel J West Journal: Front Endocrinol (Lausanne) Date: 2021-06-18 Impact factor: 5.555
Authors: E Louise Thomas; Madeleine Cule; Yi Liu; Nicolas Basty; Brandon Whitcher; Jimmy D Bell; Elena P Sorokin; Nick van Bruggen Journal: Elife Date: 2021-06-15 Impact factor: 8.140