N Jung1, S Rieg2. 1. Department I for Internal Medicine, University Hospital of Cologne, 50924, Cologne, Germany. norma.jung@uk-koeln.de. 2. Division of Infectious Diseases, Department of Medicine II, Medical Center, University of Freiburg, 79106, Freiburg, Germany.
Abstract
AIMS: Staphylococcus aureus bloodstream infection is one of the most common serious bacterial infections worldwide. It represents a heterogenous clinical entity with a high risk of metastatic complications and a high in-hospital mortality ranging between 20 and 30%. The outcome can be improved by optimised diagnostic and therapeutic management. Thus, our minireview should provide important and often missed pieces of information in the management of S. aureus bloodstream infection. METHODS: We describe the essentials in the management of S. aureus bloodstream infection. RESULTS: Five essentials were identified: 1) S. aureus bacteremia should always be considered clinically significant. 2) Length of bacteremia and fever is relevant for diagnostic workup, duration of therapy and prognosis. 3) Prompt identification and eradication of portal of entry and infective/metastatic foci are essential. 4) Infective endocarditis should be excluded. 5) Intravenous treatment for at least two weeks up to 4-6 weeks with antistaphylococcal penicillins for MSSA and vancomycin or daptomycin for MRSA bloodstream infection is indicated. CONCLUSION: Further efforts should be undertaken to increase the adherence to the essentials in the management of S. aureus bloodstream infection.
AIMS: Staphylococcus aureus bloodstream infection is one of the most common serious bacterial infections worldwide. It represents a heterogenous clinical entity with a high risk of metastatic complications and a high in-hospital mortality ranging between 20 and 30%. The outcome can be improved by optimised diagnostic and therapeutic management. Thus, our minireview should provide important and often missed pieces of information in the management of S. aureus bloodstream infection. METHODS: We describe the essentials in the management of S. aureus bloodstream infection. RESULTS: Five essentials were identified: 1) S. aureus bacteremia should always be considered clinically significant. 2) Length of bacteremia and fever is relevant for diagnostic workup, duration of therapy and prognosis. 3) Prompt identification and eradication of portal of entry and infective/metastatic foci are essential. 4) Infective endocarditis should be excluded. 5) Intravenous treatment for at least two weeks up to 4-6 weeks with antistaphylococcal penicillins for MSSA and vancomycin or daptomycin for MRSA bloodstream infection is indicated. CONCLUSION: Further efforts should be undertaken to increase the adherence to the essentials in the management of S. aureus bloodstream infection.
Authors: Bharath Raj Palraj; Larry M Baddour; Erik P Hess; James M Steckelberg; Walter R Wilson; Brian D Lahr; M Rizwan Sohail Journal: Clin Infect Dis Date: 2015-03-25 Impact factor: 9.079
Authors: Catherine Liu; Arnold Bayer; Sara E Cosgrove; Robert S Daum; Scott K Fridkin; Rachel J Gorwitz; Sheldon L Kaplan; Adolf W Karchmer; Donald P Levine; Barbara E Murray; Michael J Rybak; David A Talan; Henry F Chambers Journal: Clin Infect Dis Date: 2011-01-04 Impact factor: 9.079
Authors: Clara Lehmann; Reinhard Berner; Johannes R Bogner; Oliver A Cornely; Katja de With; Susanne Herold; Winfried V Kern; Sebastian Lemmen; Mathias W Pletz; Bernhard Ruf; Bernd Salzberger; Hans Jürgen Stellbrink; Norbert Suttorp; Andrew J Ullmann; Gerd Fätkenheuer; Norma Jung Journal: Infection Date: 2017-03-13 Impact factor: 3.553
Authors: Vance G Fowler; Maren K Olsen; G Ralph Corey; Christopher W Woods; Christopher H Cabell; L Barth Reller; Allen C Cheng; Tara Dudley; Eugene Z Oddone Journal: Arch Intern Med Date: 2003-09-22
Authors: Achim J Kaasch; Gavin Barlow; Jonathan D Edgeworth; Vance G Fowler; Martin Hellmich; Susan Hopkins; Winfried V Kern; Martin J Llewelyn; Siegbert Rieg; Jesús Rodriguez-Baño; Matthew Scarborough; Harald Seifert; Alex Soriano; Robert Tilley; M Estée Tőrők; Verena Weiß; A Peter R Wilson; Guy E Thwaites Journal: J Infect Date: 2013-11-16 Impact factor: 6.072
Authors: Hagen Frickmann; Andreas Hahn; Stefan Berlec; Johannes Ulrich; Moritz Jansson; Norbert Georg Schwarz; Philipp Warnke; Andreas Podbielski Journal: Eur J Microbiol Immunol (Bp) Date: 2019-10-16
Authors: Laura Herrera-Hidalgo; Rafael Luque-Márquez; Aristides de Alarcon; Ana Belén Guisado-Gil; Belen Gutierrez-Gutierrez; Maria Dolores Navarro-Amuedo; Julia Praena-Segovia; Juan Manuel Carmona-Caballero; Elena Fraile-Ramos; Alicia Gutierrez-Valencia; Luis Eduardo Lopez-Cortes; Maria Victoria Gil-Navarro Journal: J Clin Med Date: 2022-03-11 Impact factor: 4.241