A multiple injection regimen using an insulin injection pen and pre-filled cartridged soluble human insulin in adolescents with diabetes.

A multiple insulin injection regimen using a self-contained injection device Novopen (Novo Industries, Bagsvaerd, Copenhagen, Denmark) was assessed in 11 adolescents (age range 12.1-16.9 years) with diabetes. Ten patients completed the 3-month study period and eight expressed a wish to continue with the regimen, finding that the advantages it offered out-weighed the inconvenience of multiple injections. Mean glycosylated haemoglobin fell over the 3 months of the study period from 13.7 +/- 2.7% to 11.7 +/- 3.4% (NS) and there was a trend towards lower mean blood values which reached significance at the pre-lunch measurement (p less than 0.02).