Literature DB >> 29510900

Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment.

Tamorah R Lewis1, Elaine L Shelton2, Sara L Van Driest3, Prince J Kannankeril4, Jeff Reese5.   

Abstract

Patent ductus arteriosus (PDA) is a frequent, complex, and difficult to treat clinical syndrome among preterm infants in the neonatal intensive care unit. In addition to known clinical risk factors, there are emerging data about genetic predisposition to PDA in both animal and human models. Clinical response and toxicity from drugs used to treat PDA are highly variable. Developmental and genetic aspects of pharmacokinetics and pharmacodynamics influence exposure and response to pharmacologic therapies. Given the variable efficacy and toxicity of known drug therapies, novel therapeutic targets for PDA treatment offer the promise of precision medicine. This review addresses the known genetic contributions to prolonged ductal patency, variability in response to drug therapy for PDA, and potential novel drug targets for future PDA treatment discovery.
Copyright © 2018 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Ductus arteriosus; Genetic predisposition; Infant; Newborn

Mesh：

Substances：

Year:  2018        PMID： 29510900      PMCID： PMC6098727          DOI： 10.1016/j.siny.2018.02.006

Source DB:  PubMed          Journal:  Semin Fetal Neonatal Med        ISSN： 1744-165X            Impact factor:   3.926


  91 in total

Review 1.  Genetics of patent ductus arteriosus susceptibility and treatment.

Authors:  Hanine Hajj; John M Dagle
Journal:  Semin Perinatol       Date:  2012-04       Impact factor: 3.300

2.  Developmental expression of aryl, estrogen, and hydroxysteroid sulfotransferases in pre- and postnatal human liver.

Authors:  Zhengbo Duanmu; Amy Weckle; Sevasti B Koukouritaki; Ronald N Hines; Josie L Falany; Charles N Falany; Thomas A Kocarek; Melissa Runge-Morris
Journal:  J Pharmacol Exp Ther       Date:  2005-12-09       Impact factor: 4.030

3.  Lamb ductus arteriosus: effect of prostaglandin synthesis inhibitors on the muscle tone and the response to prostaglandin E2.

Authors:  F Coceani; P M Olley; E Bodach
Journal:  Prostaglandins       Date:  1975-02

4.  The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.

Authors:  Carmen Martínez; Elena García-Martín; Gerardo Blanco; Francisco J G Gamito; José M Ladero; José A G Agúndez
Journal:  Br J Clin Pharmacol       Date:  2005-01       Impact factor: 4.335

Review 5.  Inadvertent relaxation of the ductus arteriosus by pharmacologic agents that are commonly used in the neonatal period.

Authors:  Jeff Reese; Alex Veldman; Lisa Shah; Megan Vucovich; Robert B Cotton
Journal:  Semin Perinatol       Date:  2010-06       Impact factor: 3.300

6.  Gender dependent association between perinatal morbidity and estrogen receptor-alpha Pvull polymorphism.

Authors:  László Derzbach; András Treszl; Adám Balogh; Barna Vásárhelyi; Tivadar Tulassay; János Rigó J
Journal:  J Perinat Med       Date:  2005       Impact factor: 1.901

7.  Effects of Advancing Gestation and Non-Caucasian Race on Ductus Arteriosus Gene Expression.

Authors:  Nahid Waleh; Anne Marie Barrette; John M Dagle; Allison Momany; Chengshi Jin; Nancy K Hills; Elaine L Shelton; Jeff Reese; Ronald I Clyman
Journal:  J Pediatr       Date:  2015-08-08       Impact factor: 4.406

8.  Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice.

Authors:  Jianhe Huang; Lan Cheng; Jian Li; Mary Chen; Deying Zhou; Min Min Lu; Aaron Proweller; Jonathan A Epstein; Michael S Parmacek
Journal:  J Clin Invest       Date:  2008-02       Impact factor: 14.808

9.  Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny.

Authors:  Ronald N Hines; Pippa M Simpson; D Gail McCarver
Journal:  Drug Metab Dispos       Date:  2016-01-29       Impact factor: 3.922

10.  Angiotensin II type 1 receptor A1166C polymorphism and prophylactic indomethacin treatment induced ductus arteriosus closure in very low birth weight neonates.

Authors:  Andras Treszl; Miklos Szabo; Gyorgy Dunai; Andras Nobilis; Istvan Kocsis; Tamas Machay; Tivadar Tulassay; Barna Vasarhelyi
Journal:  Pediatr Res       Date:  2003-08-06       Impact factor: 3.756
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  9 in total

Review 1.  Novel drug targets for ductus arteriosus manipulation: Looking beyond prostaglandins.

Authors:  Elaine L Shelton; Gautam K Singh; Colin G Nichols
Journal:  Semin Perinatol       Date:  2018-05-10       Impact factor: 3.300

2.  CYP2C9*2 is associated with indomethacin treatment failure for patent ductus arteriosus.

Authors:  Sydney R Rooney; Elaine L Shelton; Ida Aka; Christian M Shaffer; Ronald I Clyman; John M Dagle; Kelli Ryckman; Tamorah R Lewis; Jeff Reese; Sara L Van Driest; Prince J Kannankeril
Journal:  Pharmacogenomics       Date:  2019-08       Impact factor: 2.533

Review 3.  Transcriptional profiling of the ductus arteriosus: Comparison of rodent microarrays and human RNA sequencing.

Authors:  Michael T Yarboro; Matthew D Durbin; Jennifer L Herington; Elaine L Shelton; Tao Zhang; Cris G Ebby; Jason Z Stoller; Ronald I Clyman; Jeff Reese
Journal:  Semin Perinatol       Date:  2018-05-10       Impact factor: 3.300

Review 4.  Patent Ductus Arteriosus of the Preterm Infant.

Authors:  Shannon E G Hamrick; Hannes Sallmon; Allison T Rose; Diego Porras; Elaine L Shelton; Jeff Reese; Georg Hansmann
Journal:  Pediatrics       Date:  2020-11       Impact factor: 7.124

5.  Path Toward Proactive Therapy for Patent Ductus Arteriosus.

Authors:  Satsuki Yamada; Andre Terzic
Journal:  Clin Pharmacol Ther       Date:  2019-08-21       Impact factor: 6.875

6.  Transcriptome Analysis Reveals Differential Gene Expression between the Closing Ductus Arteriosus and the Patent Ductus Arteriosus in Humans.

Authors:  Junichi Saito; Tomoyuki Kojima; Shota Tanifuji; Yuko Kato; Sayuki Oka; Yasuhiro Ichikawa; Etsuko Miyagi; Tsuyoshi Tachibana; Toshihide Asou; Utako Yokoyama
Journal:  J Cardiovasc Dev Dis       Date:  2021-04-16

Review 7.  Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider.

Authors:  Carl H Backes; Kevin D Hill; Elaine L Shelton; Jonathan L Slaughter; Tamorah R Lewis; Dany E Weisz; May Ling Mah; Shazia Bhombal; Charles V Smith; Patrick J McNamara; William E Benitz; Vidu Garg
Journal:  J Am Heart Assoc       Date:  2022-09-03       Impact factor: 6.106

8.  Identification of SOX18 as a New Gene Predisposing to Congenital Heart Disease.

Authors:  Hong-Yu Shi; Meng-Shi Xie; Chen-Xi Yang; Ri-Tai Huang; Song Xue; Xing-Yuan Liu; Ying-Jia Xu; Yi-Qing Yang
Journal:  Diagnostics (Basel)       Date:  2022-08-08

Review 9.  Mouse models of patent ductus arteriosus (PDA) and their relevance for human PDA.

Authors:  Michael T Yarboro; Srirupa H Gopal; Rachel L Su; Thomas M Morgan; Jeff Reese
Journal:  Dev Dyn       Date:  2021-08-14       Impact factor: 2.842
  9 in total

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