AIMS: Assuming the importance of estrogen in perinatal physiology, we tested the association of an estrogen receptor-alpha (ER-alpha) gene Pvull pP polymorphism with perinatal morbidity in premature infants. METHODS: The ER-alpha Pp genotype was determined in 69 low-birth weight (LBW) boys and 72 LBW girls, 86 term boys and 81 term girls. The association between risk factors, genotype, gender and perinatal morbidity was tested with binary logistic regression analysis. RESULTS: Boys carrying "p" allele were at lower risk for necrotizing enterocolitis (OR [95% Cl]: 0.24 [0.07-0.83]) and patent ductus arteriosus (OR [95% Cl]: 0.24 [0.05-0.97]). The carrier state of the "p" allele was associated with a 34-h shorter period of oxygen supplementation on average (P=0.0018). Boys with pp genotype were at greater risk for intraventricular hemorrhage (OR [95% Cl]: 4.39 [1.15-16.82]). No association between ER-alpha Pvull polymorphism and morbidity was present in girls. CONCLUSIONS: Since homozygocity for any Pvull alleles (i.e. having PP or pp genotype) increases the risk for at least one of the most common perinatal complications, it is likely that the heterozygous carrier state of Pvull genotypes has a protective effect, which is gender-dependent.
AIMS: Assuming the importance of estrogen in perinatal physiology, we tested the association of an estrogen receptor-alpha (ER-alpha) gene Pvull pP polymorphism with perinatal morbidity in premature infants. METHODS: The ER-alpha Pp genotype was determined in 69 low-birth weight (LBW) boys and 72 LBW girls, 86 term boys and 81 term girls. The association between risk factors, genotype, gender and perinatal morbidity was tested with binary logistic regression analysis. RESULTS:Boys carrying "p" allele were at lower risk for necrotizing enterocolitis (OR [95% Cl]: 0.24 [0.07-0.83]) and patent ductus arteriosus (OR [95% Cl]: 0.24 [0.05-0.97]). The carrier state of the "p" allele was associated with a 34-h shorter period of oxygen supplementation on average (P=0.0018). Boys with pp genotype were at greater risk for intraventricular hemorrhage (OR [95% Cl]: 4.39 [1.15-16.82]). No association between ER-alpha Pvull polymorphism and morbidity was present in girls. CONCLUSIONS: Since homozygocity for any Pvull alleles (i.e. having PP or pp genotype) increases the risk for at least one of the most common perinatal complications, it is likely that the heterozygous carrier state of Pvull genotypes has a protective effect, which is gender-dependent.
Authors: Tamorah R Lewis; Elaine L Shelton; Sara L Van Driest; Prince J Kannankeril; Jeff Reese Journal: Semin Fetal Neonatal Med Date: 2018-02-24 Impact factor: 3.926
Authors: Nahid Waleh; Ryan Hodnick; Nami Jhaveri; Suzanne McConaghy; John Dagle; Steven Seidner; Donald McCurnin; Jeffrey C Murray; Robin Ohls; Ronald I Clyman Journal: Pediatr Res Date: 2010-10 Impact factor: 3.756
Authors: Ulrika Adén; Aiping Lin; Waldemar Carlo; Alan Leviton; Jeffrey C Murray; Mikko Hallman; Richard P Lifton; Heping Zhang; Laura R Ment Journal: J Pediatr Date: 2013-07-26 Impact factor: 4.406
Authors: Donald C McCurnin; Richard A Pierce; Brigham C Willis; Ling Yi Chang; Bradley A Yoder; Ivan S Yuhanna; Philip L Ballard; Ronald I Clyman; Nahid Waleh; William Maniscalco; James D Crapo; Peter H Grubb; Philip W Shaul Journal: Am J Respir Crit Care Med Date: 2009-01-16 Impact factor: 21.405
Authors: Hesham A El-Beshbishy; Manal A Tawfeek; Nevin M Al-Azhary; Reham A Mariah; Fawzia A Habib; Lamya Aljayar; Abrar F Alahmadi Journal: Pak J Med Sci Date: 2015 Jul-Aug Impact factor: 1.088