Sunghoon Park1,2, Joon-Kee Yoon3, Nam-Su Chung4, Sang Hyun Kim5, Jinwoo Hwang6, Hyun Young Lee7,8, Kyu-Sung Kwack1,2. 1. 1 Department of Radiology, Ajou University School of Medicine , Suwon , South Korea. 2. 2 Musculoskeletal Imaging Laboratory, Ajou University Medical Center , Suwon , South Korea. 3. 3 Department of Nuclear Medicine and Molecular Imaging , Suwon , South Korea. 4. 4 Department of Orthopaedic Surgery, Ajou University School of Medicine , Suwon , South Korea. 5. 5 Department of Neurosurgery, Ajou University School of Medicine , Suwon , South Korea. 6. 6 Department of Clinical Science, Philips Healthcare , Seoul , South Korea. 7. 7 Regional Clinical Trial Center, Ajou University Medical Center , Suwon , South Korea. 8. 8 Department of Biostatistics, Yonsei University College of Medicine , Seoul , South Korea.
Abstract
OBJECTIVE: To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion-weighted MRI (DW MRI) parameters and 18F-fluodeoxyglucose (FDG) (PET/CT) metabolic parameters in patients with vertebral bone metastases. METHODS: 19 patients with vertebral bone metastases were retrospectively included in this institutional review board-approved study. All patients underwent IVIM DW-MRI and 18F-FDG PET/CT before treatment. The IVIM parameters [molecular diffusion coefficient (D), perfusion fraction (f), and perfusion-related D (D*)] and apparent diffusion coefficient were acquired using 11 b-values (0, 10, 15, 20, 25, 50, 80, 120, 200, 300, and 800 s mm-2). Maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis derived from 18F-FDG PET/CT were calculated using thresholds of 3.0 SUV. The associations among parameters were evaluated by Spearman's correlation analysis. RESULTS: A total of 19 patients and 41 regions of interest were included in this study. The IVIM parameter f was positively correlated with the metabolic parameters SUVmean and SUVmax [ρ = 0.499 (p < 0.01) and ρ = 0.413 (p < 0.01), respectively]. There was a weak positive correlation between D* and SUVmean (ρ = 0.321, p = 0.041). CONCLUSION: IVIM perfusion-related parameters, especially f, were correlated with 18F-FDG PET/CT metabolic parameters in patients with vertebral bone metastases. IVIM DW-MRI, used to evaluate metabolic activity, appears to have diagnostic potential for bone metastasis and may also have utility in monitoring the post-treatment response. Advances in knowledge: The use of IVIM for vertebral bone metastasis is demonstrated. f may be more suitable to reflect the metabolic activity and may facilitate another diagnostic potential for monitoring the posttreatment response.
OBJECTIVE: To investigate the relationship between intravoxel incoherent motion (IVIM) diffusion-weighted MRI (DW MRI) parameters and 18F-fluodeoxyglucose (FDG) (PET/CT) metabolic parameters in patients with vertebral bone metastases. METHODS: 19 patients with vertebral bone metastases were retrospectively included in this institutional review board-approved study. All patients underwent IVIM DW-MRI and 18F-FDG PET/CT before treatment. The IVIM parameters [molecular diffusion coefficient (D), perfusion fraction (f), and perfusion-related D (D*)] and apparent diffusion coefficient were acquired using 11 b-values (0, 10, 15, 20, 25, 50, 80, 120, 200, 300, and 800 s mm-2). Maximum and mean standardized uptake values (SUVmax and SUVmean, respectively), metabolic tumor volume, and total lesion glycolysis derived from 18F-FDG PET/CT were calculated using thresholds of 3.0 SUV. The associations among parameters were evaluated by Spearman's correlation analysis. RESULTS: A total of 19 patients and 41 regions of interest were included in this study. The IVIM parameter f was positively correlated with the metabolic parameters SUVmean and SUVmax [ρ = 0.499 (p < 0.01) and ρ = 0.413 (p < 0.01), respectively]. There was a weak positive correlation between D* and SUVmean (ρ = 0.321, p = 0.041). CONCLUSION: IVIM perfusion-related parameters, especially f, were correlated with 18F-FDG PET/CT metabolic parameters in patients with vertebral bone metastases. IVIM DW-MRI, used to evaluate metabolic activity, appears to have diagnostic potential for bone metastasis and may also have utility in monitoring the post-treatment response. Advances in knowledge: The use of IVIM for vertebral bone metastasis is demonstrated. f may be more suitable to reflect the metabolic activity and may facilitate another diagnostic potential for monitoring the posttreatment response.
Authors: Anwar R Padhani; Katherine van Ree; David J Collins; Shirley D'Sa; Andreas Makris Journal: AJR Am J Roentgenol Date: 2013-01 Impact factor: 3.959
Authors: Johannes Grueneisen; Karsten Beiderwellen; Philipp Heusch; Paul Buderath; Bahriye Aktas; Marcel Gratz; Michael Forsting; Thomas Lauenstein; Verena Ruhlmann; Lale Umutlu Journal: PLoS One Date: 2014-05-07 Impact factor: 3.240