Literature DB >> 29508256

Cladosporamide A, a new protein tyrosine phosphatase 1B inhibitor, produced by an Indonesian marine sponge-derived Cladosporium sp.

Henki Rotinsulu1,2, Hiroyuki Yamazaki3, Shino Sugai1, Natsuki Iwakura1, Defny S Wewengkang1,2, Deiske A Sumilat1,4, Michio Namikoshi1.   

Abstract

Cladosporamide A (1), a new protein tyrosine phosphatase (PTP) 1B inhibitor, was isolated together with a known prenylated flavanone derivative (2) from the culture broth of an Indonesian marine sponge-derived Cladosporium sp. TPU1507 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on 1D and 2D NMR data. Compound 1 modestly inhibited PTP1B and T-cell PTP (TCPTP) activities with IC50 values of 48 and 54 μM, respectively. The inhibitory activity of 2 against PTP1B (IC50 = 11 μM) was approximately 2-fold stronger than that against TCPTP (IC50 = 27 μM).

Entities:  

Keywords:  Cladosporamide A; Cladosporium sp.; Inhibitor; Marine sponge-derived fungus; Protein tyrosine phosphatase 1B

Mesh：

Substances：

Year:  2018        PMID： 29508256     DOI： 10.1007/s11418-018-1193-y

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  18 in total

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