Literature DB >> 29507072

Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis.

Narmada Fernando1, Rajiva de Silva2, Shiroma M Handunnetti3, Lilani Karunanayake4, Nipun Lakshitha De Silva5, H Janaka de Silva6, Senaka Rajapakse5, Sunil Premawansa7.   

Abstract

The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases (P = 0.01). IL-6 and IL-8 levels were low in patients who received >5 antimicrobial doses (P < 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered (r = -0.315; P = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  ceftriaxone; inflammatory cytokines; interleukin-8; leptospirosis

Mesh：

Substances：

Year:  2018        PMID： 29507072      PMCID： PMC5923126          DOI： 10.1128/AAC.02312-17

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Association of high plasma TNF-alpha levels and TNF-alpha/IL-10 ratios with TNF2 allele in severe P. falciparum malaria patients in Sri Lanka.

Authors:  M K Perera; N P Herath; S L Pathirana; M Phone-Kyaw; H K Alles; K N Mendis; S Premawansa; S M Handunnetti
Journal:  Pathog Glob Health       Date:  2013-01       Impact factor: 2.894

2.  Use of ceftriaxone in patients with severe leptospirosis.

Authors:  Lampros Raptis; Georgios Pappas; Nikolaos Akritidis
Journal:  Int J Antimicrob Agents       Date:  2006-08-07       Impact factor: 5.283

3.  The effect of three broad-spectrum antimicrobials on mononuclear cell responses to encapsulated bacteria: evidence for down-regulation of cytokine mRNA transcription by trovafloxacin.

Authors:  M Purswani; S Eckert; H Arora; R Johann-Liang; G J Noel
Journal:  J Antimicrob Chemother       Date:  2000-12       Impact factor: 5.790

4.  Cytokines in human leptospirosis.

Authors:  Anna Papa; Tzimoula Kotrotsiou
Journal:  Trans R Soc Trop Med Hyg       Date:  2015-12       Impact factor: 2.184

5.  Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines.

Authors:  Teresa Krakauer; Marilyn Buckley
Journal:  Antimicrob Agents Chemother       Date:  2003-11       Impact factor: 5.191

6.  Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays.

Authors:  Wilco de Jager; Katarzyna Bourcier; Ger T Rijkers; Berent J Prakken; Vicki Seyfert-Margolis
Journal:  BMC Immunol       Date:  2009-09-28       Impact factor: 3.615

7.  Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.

Authors:  Eliana A G Reis; José E Hagan; Guilherme S Ribeiro; Andrea Teixeira-Carvalho; Olindo A Martins-Filho; Ruth R Montgomery; Albert C Shaw; Albert I Ko; Mitermayer G Reis
Journal:  PLoS Negl Trop Dis       Date:  2013-09-19

8.  Soluble ST2 levels are associated with bleeding in patients with severe Leptospirosis.

Authors:  Jiri F P Wagenaar; M Hussein Gasem; Marga G A Goris; Mariska Leeflang; Rudy A Hartskeerl; Tom van der Poll; Cornelis van 't Veer; Eric C M van Gorp
Journal:  PLoS Negl Trop Dis       Date:  2009-06-02

9.  Protein Carbonyl as a Biomarker of Oxidative Stress in Severe Leptospirosis, and Its Usefulness in Differentiating Leptospirosis from Dengue Infections.

Authors:  Narmada Fernando; Shalini Wickremesinghe; Roshan Niloofa; Chaturaka Rodrigo; Lilani Karunanayake; H Janaka de Silva; A R Wickremesinghe; Sunil Premawansa; Senaka Rajapakse; Shiroma M Handunnetti
Journal:  PLoS One       Date:  2016-06-09       Impact factor: 3.240
  9 in total
  3 in total

1.  Raised levels of Il-6, Il-17a, and Il-22 in fatal leptospirosis.

Authors:  Wan Shahriman Yushdie Wan Yusoff; Maha Abdullah; Zamberi Sekawi; Fairuz Amran; Muhammad Yazli Yuhana; Niazlin Mohd Taib; Ivan Kok Seng Yap; Leslie Thian Lung Than; Anim Md Shah; Alex van Belkum; Syafinaz Amin Nordin
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2019-09-16       Impact factor: 3.267

2.  Contributing role of TNF, IL-10, sTNFR1 and TNF gene polymorphisms in disease severity of leptospirosis.

Authors:  Thilini Nisansala; Manjula Weerasekera; Nilantha Ranasinghe; Chamil Marasinghe; Chandika Gamage; Neluka Fernando; Chinthika Gunasekara
Journal:  Med Microbiol Immunol       Date:  2021-06-23       Impact factor: 4.148

3.  Cytokine response in human leptospirosis with different clinical outcomes: a systematic review.

Authors:  Indika Senavirathna; Devarajan Rathish; Suneth Agampodi
Journal:  BMC Infect Dis       Date:  2020-04-07       Impact factor: 3.090
  3 in total

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